Patents by Inventor PAOLA MALERBA

PAOLA MALERBA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus and methods for estimating an electrical stimulation effect on cortical neurons
    Patent number: 10967181
    Abstract: A method is disclosed for predicting the stimulation effect of cortical neurons in response to extracellular electrical stimulation. The method comprising the steps of defining an electrode configuration, defining a reconstructed neuronal cell type, wherein the reconstructed neuronal cell is characteristic of the physical and electrical properties of a neuronal cell, computing an electric field potential at the reconstructed neuronal cell, computing an effective transmembrane current of an arborization of the reconstructed neuronal cell, and determining a probability of activation of the reconstructed neuronal cell. A method for inducing an electrical stimulation effect on a cortical column is also disclosed. In an embodiment, the predicted network response of a cortical column is used to configure one or more electrodes to induce cortical stimulation.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 6, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Maksim Bazhenov, Eric Halgren, Maxim Komarov, Paola Malerba
  • APPARATUS AND METHODS FOR ESTIMATING AN ELECTRICAL STIMULATION EFFECT ON CORTICAL NEURONS
    Publication number: 20190111257
    Abstract: A method is disclosed for predicting the stimulation effect of cortical neurons in response to extracellular electrical stimulation. The method comprising the steps of defining an electrode configuration, defining a reconstructed neuronal cell type, wherein the reconstructed neuronal cell is characteristic of the physical and electrical properties of a neuronal cell, computing an electric field potential at the reconstructed neuronal cell, computing an effective transmembrane current of an arborization of the reconstructed neuronal cell, and determining a probability of activation of the reconstructed neuronal cell. A method for inducing an electrical stimulation effect on a cortical column is also disclosed. In an embodiment, the predicted network response of a cortical column is used to configure one or more electrodes to induce cortical stimulation.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventors: MAKSIM BAZHENOV, ERIC HALGREN, MAXIM KOMAROV, PAOLA MALERBA