Patents by Inventor Paola OCCHETTA

Paola OCCHETTA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic devices and related methods for generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs
    Patent number: 10961492
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 30, 2021
    Assignees: POLITECNICO DI MILANO, FONDAZIONE CARIPLO
    Inventors: Alberto Redaelli, Marco Rasponi, Paola Occhetta
  • MICROFLUIDIC DEVICES AND RELATED METHODS FOR GENERATION AND/OR CULTURE AND/OR MATURATION OF THREE-DIMENSIONAL CELLS AND/OR TISSUE CONSTRUCTS
    Publication number: 20180105782
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Application
    Filed: April 28, 2016
    Publication date: April 19, 2018
    Inventors: Alberto REDAELLI, Marco RASPONI, Paola OCCHETTA