Patents by Inventor Paolo A. Centrella

Paolo A. Centrella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TAGGING DNA-ENCODED LIBRARIES
    Publication number: 20210002630
    Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
    Type: Application
    Filed: May 7, 2020
    Publication date: January 7, 2021
    Inventors: Anthony D. KEEFE, Richard W. WAGNER, Alexander LITOVCHICK, Matthew CLARK, John CUOZZO, Ying ZHANG, Paolo A. CENTRELLA, Christopher D. HUPP
  • Methods for tagging DNA-encoded libraries
    Patent number: 10865409
    Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: December 15, 2020
    Assignee: X-Chem, Inc.
    Inventors: Anthony D. Keefe, Richard W. Wagner, Alexander Litovchick, Matthew Clark, John W. Cuozzo, Ying Zhang, Paolo A. Centrella, Christopher D. Hupp
  • METHODS FOR TAGGING DNA-ENCODED LIBRARIES
    Publication number: 20140315762
    Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
    Type: Application
    Filed: September 7, 2012
    Publication date: October 23, 2014
    Applicant: X-Chem, Inc.
    Inventors: Anthony D. Keefe, Richard W. Wagner, Alexander Litovchick, Matthew Clark, John W. Cuozzo, Ying Zhang, Paolo A. Centrella, Christopher D. Hupp
  • Methods for synthesis of encoded libraries
    Patent number: 8598089
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: December 3, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 8410028
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 2, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20120245040
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 27, 2012
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES
    Publication number: 20120071329
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: March 22, 2012
    Applicant: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110251089
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: October 13, 2011
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for identifying compounds of interest using encoded libraries
    Patent number: 7989395
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: August 2, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7972992
    Abstract: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: July 5, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110136697
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 9, 2011
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry MORGAN, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7935658
    Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 3, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Publication number: 20090062147
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: October 4, 2007
    Publication date: March 5, 2009
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for identifying compounds of interest using encoded libraries
    Publication number: 20070224607
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: October 23, 2006
    Publication date: September 27, 2007
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry Morgan, Stephen Hale, Christopher Arico-Muendel, Matthew Clark, Richard Wagner, David Israel, Malcolm Gefter, Dennis Benjamin, Nils Hansen, Malcolm Kavarana, Steffen Creaser, George Franklin, Paolo Centrella, Raksha Acharya
  • Methods for synthesis of encoded libraries
    Publication number: 20070042401
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: June 9, 2006
    Publication date: February 22, 2007
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher Arico-Muendel, Matthew Clark, Richard Wagner, David Israel, Malcolm Gefter, Dennis Benjamin, Nils Hansen, Malcolm Kavarana, Steffen Creaser, George Franklin, Paolo Centrella, Raksha Acharya
  • Methods for synthesis of encoded libraries
    Publication number: 20050158765
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: December 17, 2004
    Publication date: July 21, 2005
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher Arico-Muendel, Matthew Clark, Richard Wagner, David Israel, Malcolm Gefter, Dennis Benjamin, Nils Hansen, Malcolm Kavarana, Steffen Creaser, George Franklin, Paolo Centrella, Raksha Acharya