Patents by Inventor Paolo Caliceti

Paolo Caliceti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210030714
    Abstract: The present invention relates to a compound of formula (1): or an analogue thereof or a pharmaceutically acceptable salt thereof, for use in the treatment of a brain tumor, wherein the compound is administered intranasally and relative pharmaceutical compositions.
    Type: Application
    Filed: February 5, 2019
    Publication date: February 4, 2021
    Applicants: UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA", FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, UNIVERSITA DEGLIS STUDI DI PADOVA
    Inventors: Cristina LIMATOLA, Giuseppina D'ALESSANDRO, Lucia DI MARCOTULLIO, Paola INFANTE, Bruno BOTTA, Mattia MORI, Francesca GHIRGA, Cinzia INGALLINA, Simone BERARDOZZI, Paolo CALICETI, Stefano SALMASO, Michela DE MARTINO, Francesco GASPARRINI, Deborah QUAGLIO
  • Publication number: 20150252120
    Abstract: The present invention relates to hyaluronic acid derivative of Formula I, their synthesis and use thereof as cosmetics or as medicaments in a subject in need.
    Type: Application
    Filed: October 7, 2013
    Publication date: September 10, 2015
    Inventors: Antonino Di Pietro, Francesca Cavazza, Paolo Caliceti
  • Patent number: 8546493
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— where n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 1, 2013
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Francesco M. Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 8354477
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: January 15, 2013
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Publication number: 20100298496
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Application
    Filed: August 3, 2010
    Publication date: November 25, 2010
    Applicant: Nektar Therapeutics
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Publication number: 20090054590
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Application
    Filed: September 20, 2008
    Publication date: February 26, 2009
    Applicant: Nektar Therapeutics AL, Corporation
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 7317002
    Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention of diagnosis of growth hormone deficiency, are also an object of the present invention.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: January 8, 2008
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Publication number: 20050159353
    Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention of diagnosis of growth hormone deficiency, are also an object of the present invention.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 21, 2005
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Francesco Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 6869932
    Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention or diagnosis of growth hormone deficiency, are also an object of the present invention.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: March 22, 2005
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 6790942
    Abstract: Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH2—CH2O)n—(CO)—NH—X—(CO)—NH—Z wherein R represents a lower alkyl group, n is an integer between 25 and 250, X when combined with adjcacent NH and CO groups represents a dipeptide residue, and Z when combined with the adjacent group represents a biologically active peptide or protein.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: September 14, 2004
    Assignee: Debio Recherche Pharmaceutique
    Inventors: Oddone Schiavon, Francesco Veronese, Paolo Caliceti, Piero Orsolini
  • Publication number: 20040029794
    Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N &agr; , characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention or diagnosis of growth hormone deficiency, are also an object of the present invention.
    Type: Application
    Filed: November 20, 2002
    Publication date: February 12, 2004
    Applicant: Applied Research Systems ARS Holding N.V.
    Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Publication number: 20030114647
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 1
    Type: Application
    Filed: April 10, 2002
    Publication date: June 19, 2003
    Applicant: Shearwater Corporation
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 6528485
    Abstract: Described are various human growth hormone releasing factor-PEG conjugates as well as their pharmaceutical use.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: March 4, 2003
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Publication number: 20010007765
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 1
    Type: Application
    Filed: August 27, 1998
    Publication date: July 12, 2001
    Inventors: J. MILTON HARRIS, FRANCESCO MARIA VERONESE, PAOLO CALICETI, ODDONE SCHIAVON
  • Patent number: 5932462
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure ##STR1## wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms poly.sub.a and poly.sub.b, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings and ester groups in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure ##STR2## where mPEG.sub.a and mPEG.sub.b have the structure CH.sub.3 O--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- wherein n may be the same or different for mPEG.sub.a and mPEG.sub.b and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: August 3, 1999
    Assignee: Shearwater Polymers, Inc.
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Patent number: 5631322
    Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein --Z--X--Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Consiglio Nazionale delle Ricerche
    Inventors: Francesco M. Veronese, Oddone Schiavon, Paolo Caliceti, Luciana Sartore, Elisabetta Ranucci, Paolo Ferruti
  • Patent number: 5631336
    Abstract: A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas ##STR1## wherein R and R.sup.1 are C.sub.1 to C.sub.4 alkyl or substituted alkyl; n is 0 to 20; R.sup.II is ethylene; R.sup.III is C.sub.1 to C.sub.24 alkylene or substituted alkylene; and R.sup.IV is C.sub.1 to C.sub.4 alkyl or substituted alkyl; can be prepared by polymerizing an N-vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.
    Type: Grant
    Filed: August 26, 1993
    Date of Patent: May 20, 1997
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Paolo Ferruti, Elisabetta Ranucci, Luciana Sartore, Paolo Caliceti, Oddone Schiavon, Francesco M. Veronese
  • Patent number: 5629384
    Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein -Z-X-Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: May 13, 1997
    Assignee: Consiglio Nazionale delle Ricerche
    Inventors: Francesco M. Veronese, Oddone Schiavon, Paolo Caliceti, Luciana Sartore, Elisabetta Ranucci, Paolo Ferruti
  • Patent number: 5514572
    Abstract: A method for preparing protease-polyethylene glycol adducts is presented wherein the immobilized reversible inhibitor, benzamidine, prevents reaction of activated polyethylene glycol with the active site of the protease. Improved activity against macromolecular substrates is obtained compared to when the benzamidine is in solution during the conjugation reaction.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: May 7, 1996
    Assignee: Consiglio Nazionale delle Ricerche
    Inventors: Francesco Veronese, Paolo Caliceti, Oddone Schiavon, Sartore Luciana