Patents by Inventor Paolo Dambruoso

Paolo Dambruoso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11583527
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: February 21, 2023
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20220054490
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11197859
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: December 14, 2021
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Triazoles as Kv3 inhibitors
    Patent number: 11180461
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: November 23, 2021
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20200360379
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • TRIAZOLES AS KV3 INHIBITORS
    Publication number: 20200172496
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • Triazoles as Kv3 inhibitors
    Patent number: 10611735
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 7, 2020
    Assignee: Autifony Therapeutics Limited
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20190192516
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 27, 2019
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 10265316
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: April 23, 2019
    Assignee: AUTIFONY THERAPEUCTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • TRIAZOLES AS KV3 INHIBITORS
    Publication number: 20190071405
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • Triazoles as KV3 inhibitors
    Patent number: 10160730
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: December 25, 2018
    Assignee: Autifony Therapeutics Limited
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20170273981
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: June 13, 2017
    Publication date: September 28, 2017
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • TRIAZOLES AS KV3 INHIBITORS
    Publication number: 20160318882
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Application
    Filed: July 12, 2016
    Publication date: November 3, 2016
    Inventors: Agostino MARASCO, Giuseppe ALVARO, Anne DÈCOR, Dieter HAMPRECHT, Paolo DAMBRUOSO, Simona TOMMASI
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20160251340
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: April 7, 2016
    Publication date: September 1, 2016
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • Triazoles as Kv3 inhibitors
    Patent number: 9422252
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: August 23, 2016
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 9346790
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: May 24, 2016
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • TRIAZOLES AS KV3 INHIBITORS
    Publication number: 20150111910
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Application
    Filed: May 22, 2013
    Publication date: April 23, 2015
    Applicant: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20130267510
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: December 6, 2011
    Publication date: October 10, 2013
    Applicant: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large
  • Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors
    Patent number: 8178549
    Abstract: The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: May 15, 2012
    Assignee: Glaxo Group Limited
    Inventors: Barbara Bertani, Francesca Cardullo, Paolo Dambruoso, Paola Marzorati, Fabrizio Micheli, Alessandra Pasquarello, Catia Seri, Giovanna Tedesco
  • AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
    Publication number: 20100210672
    Abstract: The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
    Type: Application
    Filed: October 1, 2008
    Publication date: August 19, 2010
    Inventors: Barbara Bertani, Francesca Cardullo, Paolo Dambruoso, Paola Marzorati, Fabrizio Micheli, Alessandra Pasquarello, Catia Seri, Giovanna Tedesco