Patents by Inventor Paolo Ghetti

Paolo Ghetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline irinotecan hydrochloride and methods for its preparation
    Patent number: 8247426
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: August 21, 2012
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Stereoselective process and crystalline forms of a camptothecin
    Patent number: 8124769
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: February 28, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Stereoselective process and crystalline forms of a camptothecin
    Patent number: 8101758
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: January 24, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN
    Publication number: 20100311784
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN
    Publication number: 20100311783
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Stereoselective process and crystalline forms of a camptothecin
    Patent number: 7799921
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 21, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • CRYSTALLINE IRINOTECAN HYDROCHLORIDE AND METHODS FOR ITS PREPARATION
    Publication number: 20100179180
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 15, 2010
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni POZZI, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN
    Publication number: 20090239893
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 24, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Crystalline Polymorphs of Topotecan Hydrochloride and Methods for the Preparation Thereof
    Publication number: 20090192184
    Abstract: The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms ? and ?, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form ? can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form ? can be prepared starting from form ?.
    Type: Application
    Filed: December 3, 2008
    Publication date: July 30, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Andrea Mazzoni, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Crystalline Form Of Cefdinir Ammonium Salt As An Intermediate For The Preparation Of Pure Cefdinir
    Publication number: 20080033169
    Abstract: The invention relates to crystalline Cefdinir ammonium salt of formula (I) and to a process for the preparation thereof. This salt is particularly advantageous in that it allows to prepare highly pure Cefdinir.
    Type: Application
    Filed: October 24, 2005
    Publication date: February 7, 2008
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Marco Alpegiani, Walter Cabri
  • Process for the preparation of highly crystalline sodium cefoperazone
    Publication number: 20040030127
    Abstract: Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20˜40° C.
    Type: Application
    Filed: December 20, 2002
    Publication date: February 12, 2004
    Inventors: Walter Cabri, Giovanni Pozzi, Paolo Ghetti, Domenico Vergani, Roberto Strigaro