Patents by Inventor Paolo Giovanni Martino Conti

Paolo Giovanni Martino Conti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TSH receptor antagonizing tetrahydroquinoline compounds
    Patent number: 9174940
    Abstract: The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: November 3, 2015
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Willem Frederik Johan Karstens, Paolo Giovanni Martino Conti, Cornelis Marius Timmers, Ralf Plate, Christianus Johannes Van Koppen
  • Non steroidal glucocorticoid receptor modulators
    Patent number: 8133885
    Abstract: The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of these derivatives to modulate glucocorticoid receptor activity.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: March 13, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Ralf Plate, Guido Jenny Rudolf Zaman, Pedro Harold Han Hermkens, Christiaan Gerardus Johannes Maria Jans, Rogier Christian Buijsman, Adrianus Petrus Antonius De Man, Paolo Giovanni Martino Conti, Scott James Lusher, Willem Hendrik Abraham Dokter
  • TSH receptor antagonizing tetrahydroquinoline compounds
    Publication number: 20110172267
    Abstract: The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 28, 2004
    Publication date: July 14, 2011
    Inventors: Willem Frederik Johan Karstens, Paolo Giovanni Martino Conti, Cornelis Marius Timmers, Ralf Plate, Christianus Johannes Van Koppen
  • NON STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS
    Publication number: 20090062262
    Abstract: The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 14, 2006
    Publication date: March 5, 2009
    Applicant: N.V. ORGANON
    Inventors: Ralf Plate, Guido Jenny Rudolf Zaman, Pedro Harold Han Hermkens, Christiaan Gerardus Johannes Maria Jans, Rogier Christian Buijsman, Adrianus Petrus Antonius De Man, Paolo Giovanni Martino Conti, Scott James Lusher, Willem Hendrik Abraham Dokter
  • Pyrimidine derivatives as IL-8 receptor antagonists
    Patent number: 7037916
    Abstract: Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: May 2, 2006
    Assignee: Pharmacopeia Drug Discovery, Inc.
    Inventors: Shawn David Erickson, John J. Baldwin, Roland Ellwood Dolle, III, James Inglese, Michael H. J. Ohlmeyer, Koc-Kan Ho, Adolph C Bohnstedt, Steven G. Kultgen, Paolo Giovanni Martino Conti, Dirk Leysen, Jaap van der Louw
  • Pyrimidine derivatives as IL-8 receptor antagonists
    Publication number: 20040087601
    Abstract: Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed.
    Type: Application
    Filed: January 10, 2003
    Publication date: May 6, 2004
    Inventors: Shawn David Erickson, John J. Baldwin, Roland Ellwood Dolle, James Inglese, Michael H.J. Ohlmeyer, Koc-Kan Ho, Adolph C. Bohnstedt, Steven G. Kultgen, Paolo Giovanni Martino Conti, Dirk Leysen, Jaap van der Louw
  • Thrombin inhibitors comprising an aminoisoquinoline group
    Patent number: 6642253
    Abstract: The invention relates to a compound having the formula (I) wherein R1 is cyclopentyl, cyclohexyl or a branched (3-4C)alkyl; R2 is cyclohexyl or phenyl; R3 is H or methyl; and A is an unsubstituted saturated 4, 5 or 6-membered ring; or a pharmaceutically acceptable salt thereof. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-mediated and thrombin-associated diseases.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: November 4, 2003
    Assignee: Akzo Nobel N. V.
    Inventors: Johannes Bernardus Maria Rewinkel, Cornelis Marius Timmers, Paolo Giovanni Martino Conti
  • THROMBIN INHIBITORS COMPRISING AN AMINOISOQUINOLINE GROUP
    Publication number: 20030166579
    Abstract: The invention relates to a compound having the formula (1) wherein R1 is cyclopentyl, cyclohexil or branched (3-4C) alkyl; R2 is cyclohexyl or phenyl; R3 is H or methyl; and A is an unsubstituted saturated 4, 5 or 6 membered ring; or a pharmaceutically acceptable salt thereof. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-medicated and thrombin-associated diseases.
    Type: Application
    Filed: April 21, 2003
    Publication date: September 4, 2003
    Inventors: Johannes Bernardus Maria Rewinkel, Cornelis Marius Timmers, Paolo Giovanni Martino Conti