Patents by Inventor Paolo Magni

Paolo Magni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240185954
    Abstract: A computer-implemented method determines pathogenicity of combinations of digenic or oligogenic variants related to a disease. A set of variants is defined and the pathogenicity is determined. The variants refer to mutations in one/both alleles of one of at least two genes. Each gene is associated with two alleles. Presence or absence of the variants in the alleles of the genes is determined. Each situation is associated with a respective combination in which each variant is present in a subset of alleles. For each combination and gene, a pathogenicity index/score is calculated, to estimate how much the variants modify functioning of the gene. The method includes describing phenotypic traits of a patient, by standardized information for patient phenotypic abnormalities, and providing input information for the pathogenicity determination to a trained algorithm. Output information is obtained from trained algorithm, representing pathogenicity of each combination of variants/mutations.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 6, 2024
    Inventors: Ivan LIMONGELLI, Susanna ZUCCA, Federica DE PAOLI, Ettore RIZZO, Paolo MAGNI, Federica BACCALINI
  • Patent number: 11150223
    Abstract: The invention concerns a method for preparing a sample to be introduced in a chromatographic analysis system from the headspace of a vial, by introducing a pressurized inert gas in said headspace, controlling the pressure or flow, and subsequently by discharging said pressure from the headspace through a loop having constant volume and through a discharge duct provided with a valve, the discharge duct branching with respect to the feed duct. To eliminate the drawbacks of the known methods, during the step of discharging the pressure, the feed duct is kept open and the pressure in said loop is controlled by detecting the feed and/or discharge pressure.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: October 19, 2021
    Assignee: THERMO FISHER SCIENTIFIC SPA
    Inventors: Paolo Magni, Stefano Pelagatti, Riccardo Facchetti, Antonio Scaglione
  • Publication number: 20180284076
    Abstract: The invention concerns a method for preparing a sample to be introduced in a chromatographic analysis system from the headspace of a vial, by introducing a pressurized inert gas in said headspace, controlling the pressure or flow, and subsequently by discharging said pressure from the headspace through a loop having constant volume and through a discharge duct provided with a valve, the discharge duct branching with respect to the feed duct. To eliminate the drawbacks of the known methods, during the step of discharging the pressure, the feed duct is kept open and the pressure in said loop is controlled by detecting the feed and/or discharge pressure.
    Type: Application
    Filed: March 14, 2018
    Publication date: October 4, 2018
    Inventors: Paolo MAGNI, Stefano PELAGATTI, Riccardo FACCHETTI, Antonio SCAGLIONE
  • Patent number: 9632064
    Abstract: An injection port for a gas chromatograph (GC) is operated such that, during an injection sequence, an inert gas is used for sample transfer to the analytical column while hydrogen is subsequently utilized for the majority of the analytical separation. This allows for a high degree of chromatographic efficiency, while also reducing unwanted chemical reactions involving hydrogen and/or reactive solvents in a hot injection port. Certain embodiments also provide an increased margin of safety when using hydrogen, since the total flow may be limited such that the concentration of hydrogen in the GC oven never exceeds a safety limit, such as the lower explosive limit.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: April 25, 2017
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Franco Ponciroli, Paolo Magni
  • Publication number: 20150330953
    Abstract: An injection port for a gas chromatograph (GC) is operated such that, during an injection sequence, an inert gas is used for sample transfer to the analytical column while hydrogen is subsequently utilized for the majority of the analytical separation. This allows for a high degree of chromatographic efficiency, while also reducing unwanted chemical reactions involving hydrogen and/or reactive solvents in a hot injection port. Certain embodiments also provide an increased margin of safety when using hydrogen, since the total flow may be limited such that the concentration of hydrogen in the GC oven never exceeds a safety limit, such as the lower explosive limit.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 19, 2015
    Inventors: Edward B. McCauley, Franco Ponciroli, Paolo Magni
  • Patent number: 8882894
    Abstract: The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: November 11, 2014
    Assignee: Thermo Fisher Scientific S.p.A.
    Inventors: Stefano Pelagatti, Eric Phillips, Paolo Magni
  • Patent number: 8871149
    Abstract: This invention is related to a gas chromatograph wherein more substitutable modules are foreseen, in particular injector modules and/or detector modules, as well as one embodiment in an oven module. Each module is insertable in a seat of the gas chromatograph mainframe with fast connections of its electronic and pneumatic means to corresponding outlets on said mainframe. Each module has its own heating element.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: October 28, 2014
    Assignee: Thermo Fisher Scientific S.p.A.
    Inventors: Giacinto Zilioli, Stefano Pelagatti, Paolo Magni
  • Publication number: 20130118231
    Abstract: A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 16, 2013
    Inventors: Edward B. McCAULEY, Paolo MAGNI
  • Patent number: 8371152
    Abstract: A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: February 12, 2013
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Paolo Magni
  • Publication number: 20120280061
    Abstract: The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
    Type: Application
    Filed: February 1, 2010
    Publication date: November 8, 2012
    Applicant: THERMO FISHER SCIENTIFIC S.P.A.
    Inventors: Stefano Pelagatti, Eric Phillips, Paolo Magni
  • Publication number: 20120103064
    Abstract: A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.
    Type: Application
    Filed: October 27, 2010
    Publication date: May 3, 2012
    Inventors: Edward B. McCauley, Paolo Magni
  • Publication number: 20120006095
    Abstract: This invention is related to a gas chromatograph wherein more substitutable modules are foreseen, in particular injector modules and/or detector modules, as well as one embodiment in an oven module. Each module is insertable in a seat of the gas chromatograph mainframe with fast connections of its electronic and pneumatic means to corresponding outlets on said mainframe. Each module has its own heating element.
    Type: Application
    Filed: April 6, 2009
    Publication date: January 12, 2012
    Applicant: THERMO FISHER SCIENTIFIC S.P.A.
    Inventors: Giacinto Zilioli, Stefano Pelagatti, Paolo Magni
  • Publication number: 20110308298
    Abstract: This invention concerns a method and a gas chromatographic instrument in which a gas feeding low pressure condition, for instance from a cylinder, is monitored by controlling an electric parameter operating on a proportional solenoid valve placed along the gas line, and wherein an alarm to the operator is foreseen when said parameter reaches a pre-set value, so to allow a cylinder substitution before the pressure falling to zero.
    Type: Application
    Filed: January 21, 2009
    Publication date: December 22, 2011
    Applicant: THERMO FISHER SCIENTIFIC S.P.A.
    Inventors: Andrea Magni, Paolo Magni
  • Patent number: 7818994
    Abstract: The present invention relates to a method for injecting a sample (i.e. a material to be analyzed that may be dissolved in a solvent) in a vaporization chamber or in a pre-column or a gas chromatograper, this method implying separately injecting a co-solvent, with the co-solvent being injected in advance of the sample and/or in a point in the vaporization chamber other than the sample injection point.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: October 26, 2010
    Assignee: Thermo Electron S.p.A.
    Inventors: Fausto Munari, Paolo Magni, Koni Grob
  • Publication number: 20090235719
    Abstract: The invention relates to a CO2-absorption device within an elemental analysis instrument, comprising at least one combustion reactor and one detector, connected by a pneumatic line for the gasses undergoing analysis emerging from the combustion reactor, along which said CO2-absorption device is arranged downstream of the combustion reactor and upstream of the detector. In order to accelerate the operational cycle and improve efficiency without excessive bulk, two regenerable CO2 filters, valve means for feeding the gasses undergoing analysis to one of said filters, alternating between one another for each analysis, and for supplying a regenerating flow of wash gas to the second filter, in the opposite direction with respect to the direction of flow of the gas undergoing analysis in the same filter are envisaged, as well as means for temporarily heating the filter during the regeneration stage.
    Type: Application
    Filed: September 5, 2006
    Publication date: September 24, 2009
    Applicant: THERMO ELECTRON S.P.A.
    Inventors: Paolo Magni, Martino Villa, Giacinto Zilioli
  • Publication number: 20090126467
    Abstract: The invention concerns a device for washing the injector in a liquid chromatography equipment, comprising a sealed passage for the injection needle and, upstream, a mobile valve for alternatively connecting said passage with the outside for introduction of the needle, or with at least one source of washing fluid.
    Type: Application
    Filed: September 6, 2006
    Publication date: May 21, 2009
    Applicant: THERMO ELECTRON S.P.A.
    Inventors: Giacinto Zilioli, Paolo Magni, Stefano Pelagatti
  • Publication number: 20080257013
    Abstract: The present invention relates to a method for injecting a sample (i.e. a material to be analyzed that may be dissolved in a solvent) in a vaporization chamber or in a pre-column or a gas chromatograper, this method implying separately injecting a co-solvent, with the co-solvent being injected in advance of the sample and/or in a point in the vaporization chamber other than the sample injection point.
    Type: Application
    Filed: May 11, 2005
    Publication date: October 23, 2008
    Applicant: Thermo Electron S.p.A.
    Inventors: Fausto Munari, Paolo Magni, Koni Grob
  • Patent number: 7396386
    Abstract: A method for obtaining reproducibility of the retention times of the components of a mixture to be analysed in an apparatus for gaschromatographic analysis provided with a capillary column, when there occurs one of the following variations: variation in the length of the column, or alternatively its replacement with a column having identical real specifications with the exception of the length, and/or variation in the pressure of the carrier gas at output from said column. The method envisages that the pneumatic resistance of the column is known and preferably measured before and after the aforesaid variations, and that a new input pressure or a new mass flow of the carrier gas will be entered into said apparatus for gaschromatographic analysis in relation to said values of pneumatic resistance.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: July 8, 2008
    Assignee: Thermo Electron S.p.A.
    Inventor: Paolo Magni
  • Patent number: 7303610
    Abstract: Chromatography column assembly of the direct heating type, comprising at least a capillary column, at least a tubular structure which envelops the capillary column and is coaxial with it, means to directly heat the column, means to detect the temperature of the column and one or more electrically insulating covering elements, wherein the tubular structure comprises a plurality of tubular meshes each formed of a plurality of filaments woven together (FIG. 3).
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: December 4, 2007
    Assignee: Thermo Electron S.p.A.
    Inventors: Giacinto Zilioli, Riccardo Facchetti, Paolo Magni
  • Patent number: 7228067
    Abstract: A direct-heating column assembly for chromatography, includes at least one capillary column and at least one element made of electrically conductive material in contact with the capillary column. The element includes a plurality of filaments woven together to form a tubular mesh that uniformly envelops the outer surface of the capillary column both in radial and longitudinal directions.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: June 5, 2007
    Assignee: Thermo Finnigan Italia S.p.A.
    Inventors: Paolo Magni, Giacinto Zilioli, Riccardo Facchetti