Patents by Inventor Paolo Senin

Paolo Senin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9623108
    Abstract: Formulation for oral administration, in the form of tablets or of powder for extemporaneous use, able to exert a beneficial effect on the cardiovascular system and having eulipidaemic activity, cholesterol-lowering and triglyceride-lowering activity, antioxidant activity, and a protective action on the vasal endothelium, comprising berberine in combination with a policosanol and/or red yeast and preferably containing an antioxidant, such as astaxanthin and/or folic acid.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: April 18, 2017
    Assignee: ROTTAPHARM S.p.A.
    Inventors: Paolo Senin, Ivo Setnikar, Luigi Angelo Rovati
  • Publication number: 20110086896
    Abstract: Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.
    Type: Application
    Filed: September 24, 2010
    Publication date: April 14, 2011
    Applicant: Rottapharm S.p.A.
    Inventors: Antonio GIORDANI, Antonino SANTORO, Paolo SENIN, Matteo GHIRRI, Francesco MAKOVEC, Paola GILOTTA, Walter PERIS, Lucio Claudio ROVATI
  • Patent number: 7824710
    Abstract: Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: November 2, 2010
    Assignee: Rottapharm S.p.A.
    Inventors: Antonio Giordani, Antonino Santoro, Paolo Senin, Matteo Ghirri, Francesco Makovec, Paola Gilotta, Walter Peris, Lucio Claudio Rovati
  • Publication number: 20100028395
    Abstract: A composition useful for cosmetic treatment of the skin containing N-acetylglucosamine and an alkaline metal sulphate in equivalent mass ratios between 1:0.5 and 1:3, optionally in association with hyaluronic acid or a salt thereof.
    Type: Application
    Filed: March 19, 2008
    Publication date: February 4, 2010
    Applicant: ROTTAPHARM S.P.A.
    Inventors: Paolo Senin, Antonino Santoro, Luigi Angelo Rovati
  • Publication number: 20090136469
    Abstract: Formulation for oral administration, in the form of tablets or of powder for extemporaneous use, able to exert a beneficial effect on the cardiovascular system and having eulipidaemic activity, cholesterol-lowering and triglyceride-lowering activity, antioxidant activity, and a protective action on the vasal endothelium, comprising berberine in combination with a policosanol and/or red yeast and preferably containing an antioxidant, such as astaxanthin and/or folic acid.
    Type: Application
    Filed: March 29, 2007
    Publication date: May 28, 2009
    Applicant: ROTTAPHARM S.P.A.
    Inventors: Paolo Senin, Ivo Setnikar, Luigi Angelo Rovati
  • Publication number: 20080102082
    Abstract: Composition for oral administration, having a health-promoting effect on the cardiovascular system, comprising as active principles a policosanol or a mixture of policosanols, red yeast and an agent selected from astaxanthin and folic acid, preferably in combination with coenzyme Q10. The composition can be used in particular for the preparation of food supplements having health-promoting effects, such as eulipidaemic effect, correction of homocysteinaemia, antioxidant action and a protective effect on the vasal endothelium.
    Type: Application
    Filed: September 20, 2005
    Publication date: May 1, 2008
    Applicant: ROTTAPHARM S.p.A.
    Inventors: Paolo Senin, Ivo Setnikar, Luigi Angelo Rovati
  • Publication number: 20070149586
    Abstract: Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A is a not hygroscopic solid, surprisingly stable to several humidity conditions in a temperature range acceptable for ordinary storage conditions. In addition its stability allows both chemical manufacturing and pharmaceutical manufacturing process consistency and reproducibility under conditions more viable and less expensive when compared to those used for highly hygroscopic solids.
    Type: Application
    Filed: February 23, 2007
    Publication date: June 28, 2007
    Applicant: ROTTAPHARM S.P.A.
    Inventors: Antonio Giordani, Antonino Santoro, Paolo Senin, Matteo Ghirri, Francesco Makovec, PaoLa Gilotta, Walter Peris, Lucio Claudio Rovati
  • Patent number: 7025998
    Abstract: A composition for the relief and/or prevention of climacteric and menopausal disorders affecting women in pre-, peri- or post-menopause, comprising Soy Isoflavones and viable lactic acid bacteria preferably Lactobacillus sporogenes aimed to enhance the absorption of Soy Isoflavones, the composition being provided in dosage forms for oral administration. Preferably the composition also comprises Equisetum arvense dry extract and a pharmaceutically acceptable calcium salt and/or Vitamin D3.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 11, 2006
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Paolo Senin, Ivo Setnikar, Angelo Luigi Rovati
  • Publication number: 20040241260
    Abstract: A composition for the relief and/or prevention of climacteric and menopausal disorders affecting women in pre-, peri- or post-menopause, comprising Soy Isoflavones and viable lactic acid bacteria preferably Lactobacillus sporogenes aimed to enhance the absorption of Soy Isoflavones, the composition being provided in dosage forms for oral administration. Preferably the composition also comprises Equisetum arvense dry extract and a pharmaceutically acceptable calcium salt and/or Vitamin D3.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 2, 2004
    Applicant: ROTTA PHARMACEUTICALS, INC.
    Inventors: Paolo Senin, Ivo Setnikar, Angelo Luigi Rovati
  • Patent number: 5976576
    Abstract: A pharmaceutical composition comprising, as active ingredient, N-4-(1H-tetrazol-5-yl)phenyl-4-(1H-tetrazol-5-yl)benzamide disodium salt (CR 2039, Andolast) or another pharmaceutically-acceptable salt thereof and a flavoring, and optionally including a pharmaceutically-acceptable inert carrier and/or a pharmaceutically-acceptable sweetener, the composition being suitable for administration by oral inhalation.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: November 2, 1999
    Assignee: Rotta Research Laboratories S.p.A.
    Inventors: Francesco Makovec, Paolo Senin, Lucio Claudio Rovati
  • Patent number: 4791215
    Abstract: New derivatives of D,L-glutamic acid and D,L-aspartic acid are described having the formulae: ##STR1## in which n is equal to 1 or 2, R.sub.1 is a phenyl group mono-, di- or tri-substituted with linear or branched C.sub.1 -C.sub.4 alkyl groups, which may be the same or different, or with halogens, with a cyano group or a trifluoromethyl group, and in which R.sub.2 is selected from the group consisting of morpholino, piperidino and amino with one or two linear, branched or cyclic alkyl group substituents containing from 1 to 8 carbon atoms, which may be the same or different, or a pharmaceutically-acceptable salt thereof.The compounds have an antagonistic activity towards bioactive polypeptides and are useful particularly in the treatment of illnesses of the digestive system and the central nervous system, as pain killers, and for the treatment of anorexia and all those affections (for example tumours) in which exogenous or endogenous bioactive polypeptides are involved.
    Type: Grant
    Filed: June 18, 1985
    Date of Patent: December 13, 1988
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Luigi Rovati, Francesco Makovec, Rolando Chiste', Paolo Senin
  • Patent number: 4642340
    Abstract: The compound consists of a mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR1## and is in the form of a crystalline powder with a melting point above 300.degree. C. The salt is stable at ambient temperatures and humidities and has pharmacological properties practically identical to those of glucosamine sulphate.
    Type: Grant
    Filed: April 30, 1982
    Date of Patent: February 10, 1987
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Paolo Senin, Francesco Makovec, Luigi Rovati
  • Patent number: 4576951
    Abstract: The subject of the invention is a new use of D,L-4-benzamido-N,N-dipropyl-glutaramic acid (proglumide) in human pain relief. According to the invention proglumide is used both alone, at dosages of from 0.5 to 30 mg/kg of body weight, and in association with analgesic-narcotic drugs, it being able to potentiate the analgesic activity of these drugs.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: March 18, 1986
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Luigi Rovati, Francesco Makovec, Paolo Senin, Pierluigi Casula
  • Patent number: 4288609
    Abstract: Compounds having the general formula: ##STR1## in which: Ad is 1-adamantyl (C.sub.10 H.sub.15) radicalA is oxygen atom or --NH--(imino) groupR is --CH.sub.3 (methyl) group or --C.sub.2 H.sub.5 (ethyl) groupR' is a linear aliphatic chain containing from 10 to 12 atoms of carbonX.sup.- is a halide ion.The halide may be chlorine or bromine. The compounds exhibit an antibacterial, antimould and antiprotozoic activity and may be formulated as pharmaceutical and cosmetic preparations or used as preservatives for food products.
    Type: Grant
    Filed: December 4, 1979
    Date of Patent: September 8, 1981
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Luigi Rovati, Francesco Makovec, Paolo Senin
  • Patent number: 4272538
    Abstract: 5-nitro-imidazole derivatives of the formula ##STR1## in which R.sub.1 is hydrogen, methyl, ethyl or phenyl, n is 2 or 3, and R.sub.2 is methyl, ethyl, carboxymethyl or carboxyethyl, and the pharamceutically acceptable acid addition salts thereof, useful as antiprotozoics.
    Type: Grant
    Filed: May 18, 1979
    Date of Patent: June 9, 1981
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Francesco Makovec, Paolo Senin, Luigi Rovati
  • Patent number: 4004008
    Abstract: Tyrosine derivatives of the formula: ##STR1## wherein: R.sub.1 is a linear or branched-chain alkyl group having 1-6 carbon atoms, terminating by a tertiary amino group; R.sub. 2 is an unsubstituted, monosubstituted or di-substituted phenyl or benzyloxy group, the substituent being --Cl, --Br, --NO.sub.2, --OCH.sub.3, --CH.sub.3 or --CF.sub.3 ; R.sub.3 is a primary, secondary or tertiary amino group or an aryl-alkylamino group having 7-9 carbon atoms; and salts of said tyrosine derivatives with pharmaceutically acceptable acids.
    Type: Grant
    Filed: February 3, 1975
    Date of Patent: January 18, 1977
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Francesco Makovec, Luigi Rovati, Paolo Senin
  • Patent number: 3985878
    Abstract: Anti-inflammatory antirheumatic compounds of the formula: ##SPC1##Wherein n.sub.1 and n.sub.2 are each either 2 or 3, and wherein the two tertiary amino-groups may, if desired, be present in the form salified by a pharmaceutically acceptable acid such as oxalic, citric, maleic, fumaric or hydrochloric acid. The preferred compound is N'-2-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxy]-ethyl-N-3-(N -benzoyl-N',N'-di-n-propyl-DL-isoglutaminoyl)-oxypropyl-piperazine, preferably in the form of dimaleate.
    Type: Grant
    Filed: July 10, 1975
    Date of Patent: October 12, 1976
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Francesco Makovec, Paolo Senin, Luigi Rovati