Patents by Inventor Paolo Strazzolini

Paolo Strazzolini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition of antibiotic L 17054 and a method for the treatment of bacterial infections using the antibiotic
    Patent number: 5132286
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: July 21, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Angelo Borghi, Paolo Strazzolini, Bruno Cavalleri, Carolina Coronelli
  • Process for preparing antibiotic L 17054
    Patent number: 5041534
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: August 20, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Adriano Malabarba, Paolo Strazzolini, angelo Borghi, Bruno Cavalleri, Carolina Coronelli
  • Carboxylic acid ester derivatives or deglucoteicoplanin
    Patent number: 4954483
    Abstract: The present invention is directed to carboxylic acid esters of deglucoteicoplanin, i.e. of the aglycon moiety of the antibiotic teicoplanin. The compounds of the invention are conveniently prepared either by deglucoteicoplanin or by any of the glycopeptides of the teicoplanin group, such as teicoplanin itself, one of its components, antibiotic L 17054 and antibiotic L 17046.
    Type: Grant
    Filed: September 8, 1988
    Date of Patent: September 4, 1990
    Assignee: Gruppo Lepetit, S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Aldo Trani, Ambrogio Magni, Bruno Cavalleri
  • Ester derivatives of antibiotic L 17046
    Patent number: 4914187
    Abstract: The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: April 3, 1990
    Assignee: Gruppo Lepetit S.p.A
    Inventors: Adriano Malabarba, Paolo Strazzolini, Ambrogio Magni, Bruno Cavalleri, Aldo Trani
  • Process for preparing antibiotic L 17392 (deglucoteicoplanin)
    Patent number: 4882419
    Abstract: Process for preparing antibiotic L, 17392 by catalytically hydrogenating a deglucoteicoplanin ester of formula ##STR1## wherein A, B and Z represent hydrogen atoms, R represents benzyl or substituted benzyl, wherein the phenyl group is substituted with at least a substituent selected from chloro, bromo, fluoro, nitro, (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy and the like, with the exclusion of the tri-nitro phenyl group, or acid addition salts thereof, to catalytic hydrogenolysis in the presence of a poisoned hydrogenation catalyst at a temperature from 10.degree. C. to 40.degree. C. and a pressure between ambient pressure and 5 atm, in an inert organic solvent preferably in the presence of a mineral acid.
    Type: Grant
    Filed: February 6, 1986
    Date of Patent: November 21, 1989
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Bruno Cavalleri
  • Process for transforming teicoplanin factor A.sub.2 component 1 into teicoplanin factor A.sub.2, component 3
    Patent number: 4725668
    Abstract: The present invention refers to a process for transforming teicoplanin factor A.sub.2 component 1 into teicoplanin factor A.sub.2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: February 16, 1988
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Paolo Strazzolini, Bruno Cavalleri
  • Antibiotic L 17046 and process for preparing it
    Patent number: 4699977
    Abstract: The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity expecially against gram-positive bacteria.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: October 13, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Angelo Borghi, Paolo Strazzolini, Bruno Cavalleri, Carolina Coronelli
  • Ester derivatives of antibiotic L 17046
    Patent number: 4661470
    Abstract: The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: April 28, 1987
    Assignee: Gruppo Lepetit S.P.A.
    Inventors: Adriano Malabarba, Ambrogio Magni, Paolo Strazzolini, Bruno Cavalleri, Aldo Trani
  • Glycopeptide antibiotic L 17046
    Patent number: 4650855
    Abstract: The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity especially against gram-positive bacteria.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: March 17, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Angelo Borghi, Bruno Cavalleri, Carolina Coronelli
  • Glycopeptide antibiotic L 17054
    Patent number: 4645827
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: February 24, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Angelo Borghi, Bruno Cavalleri, Carolina Coronelli
  • Chemical process for preparing L 17392 (deglucoteicoplanin) and its salts
    Patent number: 4629781
    Abstract: The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acidic hydrolysis conditions.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: December 16, 1986
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Paolo Strazzolini, Adriano Malabarba, Bruno Cavalleri
  • Process for preparing antibiotic L 17054
    Patent number: 4594187
    Abstract: The present invention is directed to a chemical process for preparing the antibiotic substance denominated antibiotic L 17054 and its pharmaceutically acceptable salts by selectively hydrolyzing teicoplanin or a factor or component thereof with a concentrated strong organic acid.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: June 10, 1986
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Paolo Strazzolini, Adriano Malabarba, Bruno Cavalleri