Patents by Inventor Paolo Trifiro'

Paolo Trifiro' has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazoles as histone demethylase inhibitors
    Patent number: 10961255
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: March 30, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro′, Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200299303
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 24, 2020
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10562914
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 18, 2020
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro', Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190152987
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 23, 2019
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • Cycloproplyamine derivatives useful as inhibitors of histone demethylases KDM1A
    Patent number: 9944589
    Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: April 17, 2018
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Paola Vianello, Florian Thaler, Paolo Trifiro′, Ciro Mercurio, Giuseppe Meroni
  • CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A
    Publication number: 20150315126
    Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 3, 2013
    Publication date: November 5, 2015
    Inventors: Mario Varasi, Paola Vianello, Florian Thaler, Paolo Trifiro', Ciro Mercurio, Giuseppe Meroni
  • 3,4-diarylpyrazoles as protein kinase inhibitors
    Patent number: 8946250
    Abstract: 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: February 3, 2015
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Maurizio Pulici, Fabio Zuccotto, Gabriella Traquandi, Sonia Biondaro, Paolo Trifiro′, Alessandra Badari, Stefano Nuvoloni, Giovanni Cervi, Chiara Marchionni, Michele Modugno
  • 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators
    Patent number: 8772279
    Abstract: There are provided 3,5-disubstituted derivatives of 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one compounds of formula (I) or a pharmaceutically acceptable salt thereof as defined in the present specification, which modulate the activity of protein kinases. The compounds are therefore useful in treating diseases caused by dysregulated protein kinase activity. In particular, such diseases to be treated with a compound of formula (I) of the present invention is one caused by and/or associated with disregulated protein kinase activity selected from the group consisting of cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders. The present invention also relates to processes for preparing the compounds of formula (I), combinatorial libraries thereof, pharmaceutical compositions comprising them, and methods of treating diseases utilizing pharmaceutical compositions comprising a compound of formula (I).
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 8, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Danilo Mirizzi, Sten Christian Orrenius, Paolo Trifirò
  • 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS
    Publication number: 20140005150
    Abstract: 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: August 20, 2013
    Publication date: January 2, 2014
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Maurizio Pulici, Fabio Zuccotto, Gabriella Traquandi, Sonia Biondaro, Paolo Trifiro', Alessandra Badari, Stefano Nuvoloni, Giovanni Cervi, Chiara Marchionni, Michele Modugno
  • 3,4-diarylpyrazoles as protein kinase inhibitors
    Patent number: 8541575
    Abstract: 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: September 24, 2013
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Maurizio Pulici, Fabio Zuccotto, Alessandra Badari, Stefano Nuvoloni, Giovanni Cervi, Gabriella Traquandi, Sonia Biondaro, Paolo Trifiro', Chiara Marchionni, Michele Modugno
  • 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS
    Publication number: 20130029974
    Abstract: There are provided 3,5-disubstituted derivatives of 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one compounds of formula (I) or a pharmaceutically acceptable salt thereof as defined in the present specification, which modulate the activity of protein kinases. The compounds are therefore useful in treating diseases caused by dysregulated protein kinase activity. In particular, such diseases to be treated with a compound of formula (I) of the present invention is one caused by and/or associated with disregulated protein kinase activity selected from the group consisting of cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders. The present invention also relates to processes for preparing the compounds of formula (I), combinatorial libraries thereof, pharmaceutical compositions comprising them, and methods of treating diseases utilizing pharmaceutical compositions comprising a compound of formula (I).
    Type: Application
    Filed: January 21, 2011
    Publication date: January 31, 2013
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Danilo Mirizzi, Sten Christian Orrenius, Paolo Trifirò
  • 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS
    Publication number: 20110144068
    Abstract: 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: July 23, 2009
    Publication date: June 16, 2011
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Maurizio Pulici, Fabio Zuccotto, Alessandra Badari, Stefano Nuvoloni, Giovanni Cervi, Gabriella Traquandi, Sonia Biondaro, Paolo Trifiro', Chiara Marchionni, Michele Modugno