Abstract: The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V) and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I) The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.

Abstract: The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V) and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I) The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.

Abstract: The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V) and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I) The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.

Abstract: The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V) and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I) The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.

Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.

Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.

Abstract: One aspect of our invention is a bundle rule that could make demand and/or supply of different packages more independent, which would simplify the bidding process, the verification that bids comply with a bidding format, clearing of the auction and presentation of information to traders. A second aspect is that bundling can be automatically updated with regard to auction relevant information before the auction starts or during the auction process. Several aspects of our invention can be combined in an exemplary design. Aspects of our invention can be implemented in computer systems.

Abstract: One aspect of our invention is a bundle rule that could make demand and/or supply of different packages more independent, which would simplify the bidding process, the verification that bids comply with a bidding format, clearing of the auction and presentation of information to traders. A second aspect is that bundling can be automatically updated with regard to auction relevant information before the auction starts or during the auction process. Several aspects of our invention can be combined in an exemplary design. Aspects of our invention can be implemented in computer systems.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: A power transformer/inductor includes at least one winding. The winding is made of a high voltage cable that includes an electric conductor, and around the electric conductor is arranged a first semiconducting layer, around the first semiconducting layer is an insulating layer, and around the insulating layer is a second semiconducting layer. The second semiconducting layer is directly earthed at both ends of the winding and furthermore at least at two points per turn of every winding such that one or more points are indirectly earthed.

Abstract: A power or regulating transformer with voltage regulator includes regulating windings made of a flexible conductor having an electric field containing mechanism that forces the electric field due to the current in the winding to be contained within the flexible conductor. Since virtually no electric field is to be found outside the flexible conductor of the regulating winding, the regulating winding may be formed without having to consider the electric field distribution, thus providing for a transformer with a favorable regulating winding design.

Abstract: The present invention relates to a power transformer/inductor comprising at least one winding. The windings are designed by means of a high-voltage cable, comprising an electric conductor, and around the conductor there is arranged a first semiconducting layer, around the first semiconducting layer there is arranged an insulating layer and around the insulating layer there is arranged a second semiconducting layer. The second semiconducting layer is earthed at or in the vicinity of both ends (261, 262; 281, 282) of each winding and furthermore one point between both ends (261, 262; 281, 282) is directly earthed.

Abstract: A power transformer/inductor includes at least one winding. The winding is made of a high voltage cable that includes an electric conductor, and around the electric conductor is arranged a first semiconducting layer, around the first semiconducting layer is an insulating layer, and around the insulating layer is a second semiconducting layer. The second semiconducting layer is directly earthed at both ends of the winding and furthermore at least at two points per turn of every winding such that one or more points are indirectly earthed.

Abstract: A distributed air gap material for a induction device in power systems for minimizing fringe losses, mechanical losses and noise in the core The distributed air gap material occupies a selected portion of the core and is formed of a finely divided magnetic material in a matrix of a dielectric material particles. The air gap material has a zone of transition in which the permeability values vary within the air gap material.

Abstract: A power transformer having at least one high voltage winding and one low voltage winding. Each of the windings includes at least one current-carrying conductor, a first layer having semiconducting properties provided around said conductor, a solid insulating layer provided around said first layer, and a second layer having semiconducting properties provided around said insulating layer. The windings are intermixed such that turns of the high voltage winding are mixed with turns of the low voltage winding.

Abstract: A high power static electromagnetic device with a flux path, a main winding and one or more regulation windings surrounding portions of the flux path. A control device is coupled to the flux path for selectively admitting the flux therein. In an exemplary embodiment, multiple flux paths are selectively turned on and off for including and excluding the regulation windings from the circuit. The windings may be formed of a magnetically permeable, field-confining insulating cable.

Abstract: A distributed air gap material for a induction device in power systems for minimizing fringe losses, mechanical losses and noise in the core The distributed air gap material occupies a selected portion of the core and is formed of a finely divided magnetic material in a matrix of a dielectric material particles. The air gap material has a zone of transition in which the permeability values vary within the air gap material.