Patents by Inventor Par Holmberg
Par Holmberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11136331Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.Type: GrantFiled: October 12, 2018Date of Patent: October 5, 2021Assignee: CAMBREX CHARLES CITY, INC.Inventors: Par Holmberg, Lars Eklund, David Adams, Michael Letourneau, Margus Eek, Alo Soone
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Publication number: 20210188862Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.Type: ApplicationFiled: October 12, 2018Publication date: June 24, 2021Inventors: Par HOLMBERG, Lars EKLUND, David ADAMS, Michael LETOURNEAU, Margus EEK, Alo SOONE
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Publication number: 20210118056Abstract: One aspect of our invention is a bundle rule that could make demand and/or supply of different packages more independent, which would simplify the bidding process, the verification that bids comply with a bidding format, clearing of the auction and presentation of information to traders. A second aspect is that bundling can be automatically updated with regard to auction relevant information before the auction starts or during the auction process. Several aspects of our invention can be combined in an exemplary design. Aspects of our invention can be implemented in computer systems.Type: ApplicationFiled: December 30, 2020Publication date: April 22, 2021Inventors: Par Holmberg, Keith Ruddell, Bert Willems
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Patent number: 10370382Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.Type: GrantFiled: July 26, 2016Date of Patent: August 6, 2019Assignee: Cambrex Charles City, Inc.Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
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Publication number: 20180354961Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.Type: ApplicationFiled: July 26, 2016Publication date: December 13, 2018Applicant: Cambrex Charles City, Inc.Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
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Publication number: 20180218449Abstract: One aspect of our invention is a bundle rule that could make demand and/or supply of different packages more independent, which would simplify the bidding process, the verification that bids comply with a bidding format, clearing of the auction and presentation of information to traders. A second aspect is that bundling can be automatically updated with regard to auction relevant information before the auction starts or during the auction process. Several aspects of our invention can be combined in an exemplary design. Aspects of our invention can be implemented in computer systems.Type: ApplicationFiled: January 31, 2018Publication date: August 2, 2018Inventors: Par Holmberg, Keith Ruddell, Bert Willems
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Patent number: 9981978Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2 and R3 are as described in the description, by conversion of a corresponding allylic alcohol.Type: GrantFiled: July 23, 2014Date of Patent: May 29, 2018Assignee: Cambrex Charles City, Inc.Inventors: Michael Tracey, Pär Holmberg, Belén Lindberg Martín Matute, Antonio Bermejo Gómez, Jan-Erling Bäckvall
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Patent number: 9580439Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.Type: GrantFiled: June 19, 2013Date of Patent: February 28, 2017Assignee: The Scripps Research InstituteInventors: Congxin Liang, Marcel Koenig, Yuanjun He, Par Holmberg
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Publication number: 20160168159Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2 and R3 are as described in the description, by conversion of a corresponding allylic alcohol.Type: ApplicationFiled: July 23, 2014Publication date: June 16, 2016Inventors: Michael Tracey, Pär Holmberg
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Patent number: 8962862Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.Type: GrantFiled: July 20, 2012Date of Patent: February 24, 2015Assignee: Cambrex Karlskoga ABInventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
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Publication number: 20140187789Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.Type: ApplicationFiled: July 20, 2012Publication date: July 3, 2014Applicant: CAMBREX KARLSKOGA ABInventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
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Publication number: 20130281443Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.Type: ApplicationFiled: June 19, 2013Publication date: October 24, 2013Applicant: THE SCRIPPS RESEARCH INSTITUTEInventors: Congxin Liang, Marcel Koenig, Yuanjun He, Par Holmberg
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Patent number: 8501763Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.Type: GrantFiled: March 10, 2008Date of Patent: August 6, 2013Assignee: The Scripps Research InstituteInventors: Congxin Liang, Marcel Koenig, Yuanjun He, Par Holmberg
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Publication number: 20110046121Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.Type: ApplicationFiled: March 10, 2008Publication date: February 24, 2011Applicant: The Scripps Research InstituteInventors: Congxin Liang, Marcel Koenig, Yuanjun He, Par Holmberg
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Patent number: 7046492Abstract: A power transformer/inductor includes at least one winding. The winding is made of a high voltage cable that includes an electric conductor, and around the electric conductor is arranged a first semiconducting layer, around the first semiconducting layer is an insulating layer, and around the insulating layer is a second semiconducting layer. The second semiconducting layer is directly earthed at both ends of the winding and furthermore at least at two points per turn of every winding such that one or more points are indirectly earthed.Type: GrantFiled: December 20, 2004Date of Patent: May 16, 2006Assignee: ABB ABInventors: Udo Fromm, Sven Hornfeldt, Par Holmberg, Gunnar Kylander, Li Ming, Mats Leijon
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Patent number: 6995646Abstract: A power or regulating transformer with voltage regulator includes regulating windings made of a flexible conductor having an electric field containing mechanism that forces the electric field due to the current in the winding to be contained within the flexible conductor. Since virtually no electric field is to be found outside the flexible conductor of the regulating winding, the regulating winding may be formed without having to consider the electric field distribution, thus providing for a transformer with a favorable regulating winding design.Type: GrantFiled: February 2, 1998Date of Patent: February 7, 2006Assignee: ABB ABInventors: Udo Fromm, Par Holmberg, Albert Jaksts, Mats Leijon, Christian Sasse, Thorsten Schutte
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Patent number: 6970063Abstract: The present invention relates to a power transformer/inductor comprising at least one winding. The windings are designed by means of a high-voltage cable, comprising an electric conductor, and around the conductor there is arranged a first semiconducting layer, around the first semiconducting layer there is arranged an insulating layer and around the insulating layer there is arranged a second semiconducting layer. The second semiconducting layer is earthed at or in the vicinity of both ends (261, 262; 281, 282) of each winding and furthermore one point between both ends (261, 262; 281, 282) is directly earthed.Type: GrantFiled: February 2, 1998Date of Patent: November 29, 2005Assignee: ABB ABInventors: Udo Fromm, Sven Hornfeldt, Par Holmberg, Gunnar Kylander, Li Ming, Mats Leijon
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Publication number: 20050099258Abstract: A power transformer/inductor includes at least one winding. The winding is made of a high voltage cable that includes an electric conductor, and around the electric conductor is arranged a first semiconducting layer, around the first semiconducting layer is an insulating layer, and around the insulating layer is a second semiconducting layer. The second semiconducting layer is directly earthed at both ends of the winding and furthermore at least at two points per turn of every winding such that one or more points are indirectly earthed.Type: ApplicationFiled: December 20, 2004Publication date: May 12, 2005Applicant: ASEA BROWN BOVERI ABInventors: Udo Fromm, Sven Hornfeldt, Par Holmberg, Gunnar Kylander, Li Ming, Mats Leijon
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Patent number: 6885273Abstract: A distributed air gap material for a induction device in power systems for minimizing fringe losses, mechanical losses and noise in the core The distributed air gap material occupies a selected portion of the core and is formed of a finely divided magnetic material in a matrix of a dielectric material particles. The air gap material has a zone of transition in which the permeability values vary within the air gap material.Type: GrantFiled: February 14, 2002Date of Patent: April 26, 2005Assignee: ABB ABInventors: Pan Min, Li Ming, Rongsheng Liu, Mikael Dahlgren, Par Holmberg, Gunnar Russberg, Christian Sasse, Svante Söderholm
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Patent number: 6867674Abstract: A power transformer having at least one high voltage winding and one low voltage winding. Each of the windings includes at least one current-carrying conductor, a first layer having semiconducting properties provided around said conductor, a solid insulating layer provided around said first layer, and a second layer having semiconducting properties provided around said insulating layer. The windings are intermixed such that turns of the high voltage winding are mixed with turns of the low voltage winding.Type: GrantFiled: November 30, 1998Date of Patent: March 15, 2005Assignee: Asea Brown Boveri ABInventors: Thorsten Schutte, Par Holmberg, Jan Brangefalt, Christian Sasse, Peter Carstensen