Abstract: Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.

Abstract: Here we demonstrate a contactless method to induce reversible droplet contact angle modulation on chemically inert substrates via corona discharge-based dielectric charge injection (DCI). The method involves a probe that can induce dielectric breakdown of the surrounding dielectric medium, such as air, under voltages exceeding the medium's dielectric strength. Breakdown leads to ionization of the dielectric, after which then the ions accelerate away from the sharp tip due to electrostatic repulsion, resulting in charge injection onto a target surface. With DCI, one induces wetting of a water droplet on non-wetting, non-contacting surfaces in non-polar continuous phases. DCI can achieve up to 140° contact angle modulation. Furthermore, upon removal of the voltage, the droplet dewets and returns to the initial non-wetting state. DCI can induce deposition of encapsulated materials from droplets to the non-wetting surface. DCI can also recover materials from such a surface.

Abstract: Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.