Patents by Inventor Paramesewara M. Reddy

Paramesewara M. Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for terminal substituting of a polynucleotide
    Patent number: 5319079
    Abstract: Method for substituting a substitution compound for the hydrogen of a support bound primary hydroxyl group. The support bound primary hydroxyl group is treated in an organic, substantially anhydrous solvent in the presence of a tertiary amine base and the substitution compound.The substitution compound has a positive moiety and a negative moiety. The positive moiety is selected from the group consisting of trityl, pixyl, and derivatives thereof.The reagent is selected from the group consisting of tetraalkylammonium salts, inorganic salts, and mixtures thereof. Each reagent has a cation and an anion moiety.The cation moiety of the reagent is more electropositive than the positive moiety of the substitution compound. This relationship enables the reagent to attract the negative moiety of the substitution compound.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: June 7, 1994
    Assignee: Beckman Instruments, Inc.
    Inventors: Paramesewara M. Reddy, Serge L. Beaucage, Jang Rampal