Abstract: The present disclosure relates to peptoids for inhibiting O-GlcNAcylated proteins, and in particular, the c-Rel peptide of NF-kappaB. The compounds can be used in the prevention or treatment of diseases of conditions having elevated levels of O-GlcNAcylation, such as autoimmune diseases, conditions that are related to hyperglycemia, or cancers.

Abstract: Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

Abstract: Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

Abstract: Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.

Abstract: An antibody or antibody preparation being capable of specifically binding the amino acid sequence of NF-&kgr; B-inducing kinase (NIK) MAP3K14, or a specific portion thereof, and of thereby regulating a biochemical activity of NIK, and/or enabling detection of NIK or a specific portion thereof.

Abstract: The present invention relates to a splice variant of SIVA, SIVA3, and to its use.

Abstract: The invention relates to the use of NF-?B inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules.

Abstract: The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.

Abstract: Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.

Abstract: A system that may be used to generate documents, where the system is accessible from and integratable with remote systems is provided. A document generation system that may be provided as a service, in the sense that the system may be accessed via, e.g., the Internet, from remote systems such as credit aggregators. The system takes in information regarding the requirements (e.g., type of transaction, number of parties, amount of loan, price, governing law, etc.) of the document needed (e.g., a loan application, construction contract, etc.) and produces an appropriate form based on the input information. It should be noted that access to the document generation system is effectuated by an Internet/network connection via, e.g., a partner provider system such as a DMS, a traditional credit aggregator, a credit aggregator portal, etc. Electronic signature and secure archiving may be provided for generated documents.

Abstract: The present invention relates to modulation of SIVA2 stability by N-acetylglucosamine, phosphorylation of ubiquitination in treatment or prevention of diseases, disorders or conditions.

Abstract: A system that enables parties to a real estate transaction to remotely access the system via the internet to initiate and consummate the offer/counter-offer process leading up to and including execution of a definitive purchase agreement between buyer and seller, wherein parties to the real estate transaction include the Buyer, the Seller and their respective agents. The system provides for a user interface that enables input of the transaction specification information which is typically input by the real estate agent. Subsequently, the system enables secure routing of the transaction between the parties for their online review and response. The system also provides for unique identity verification, logging and tracking functions to ensure validity and enforceability of electronic acceptance of transactions and related purchase agreements and documents by all parties.

Abstract: This invention relates to the use of the IL-2 common gamma (c?c) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules.

Abstract: Methods and agents for immune modulation and methods for identifying putative immune modulators are provided.

Abstract: The present invention relates to a splice variant of SIVA, SIVA3, and to its use.

Abstract: The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.

Abstract: The present invention is a method for handling multiple aspects of the acquisition of vehicles, such as automobiles and trucks, in a unified and streamlined fashion. A system for acquisition of vehicles that integrates various product and service providers with retailers and consumers is presented from various aspects in order to realize efficiencies and opportunities that are impossible in the present mode of vehicle acquisition.

Abstract: A system that may be used to generate documents, where the system is accessible from and integratable with remote systems is provided. A document generation system that may be provided as a service, in the sense that the system may be accessed via, e.g., the Internet, from remote systems such as credit aggregators. The system takes in information regarding the requirements (e.g., type of transaction, number of parties, amount of loan, price, governing law, etc.) of the document needed (e.g., a loan application, construction contract, etc.) and produces an appropriate form based on the input information. It should be noted that access to the document generation system is effectuated by an Internet/network connection via, e.g., a partner provider system such as a DMS, a traditional credit aggregator, a credit aggregator portal, etc. Electronic signature and secure archiving may be provided for generated documents.

Abstract: A method of treating a disease associated with NF-?B activity. The method is effected by providing to a subject in need thereof a therapeutically effective amount of an agent capable of modulating NIK-HC8 binding.

Abstract: This invention relates to the use of the IL-2 common gamma (c?c) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules