Patents by Inventor Paranji Ramaiyenger Narayanan

Paranji Ramaiyenger Narayanan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutants of and process thereof
    Patent number: 7943361
    Abstract: The present invention provides mutant Mycobacterium strains harboring a modified tyrosine phosphatase gene (mptpA or mptpB) wherein the mutant Mycobacterium strain is incapable of expressing the active tyrosine phosphatase. The invention provides a method for developing the said mutant strain from either Mycobacterium tuberculosis or Mycobacterium bovis. The mptpA or mptpB gene may be modified by replacing the internal sequences with an antibiotic resistance marker gene, which disrupts the expression of the active gene. The invention further provides a recombinant vector comprising the modified mptpA or mptpB which may be used to develop the mutant strains of mycobacteria. The invention provides a method to assess the role of tyrosine phosphatases MptpA and MptpB in the virulence and pathogenesis of Mycobacterium which can be used as potential targets for developing anti-tubercular drug.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: May 17, 2011
    Assignees: Indian Council of Medical Research, University of Delhi
    Inventors: Anil Kumar Tyagi, Ramandeep Singh, Vivek Rao, Vadakkuppattu Devasenapathi Ramanathan, Chinnambedy Nainarappan Paramasivan, Paranji Ramaiyenger Narayanan, Yogendra Singh
  • Mutants of mycobacteria and process thereof
    Publication number: 20090215031
    Abstract: The present invention provides mutant Mycobacterium strains harboring a modified tyrosine phosphatase gene (mptpA or mptpB) wherein the mutant Mycobacterium strain is incapable of expressing the active tyrosine phosphatase. The invention provides a method for developing the said mutant strain from either Mycobacterium tuberculosis or Mycobacterium bovis. The mptpA or mptpB gene may be modified by replacing the internal sequences with an antibiotic resistance marker gene, which disrupts the expression of the active gene. The invention further provides a recombinant vector comprising the modified mptpA or mptpB which may be used to develop the mutant strains of mycobacteria. The invention provides a method to assess the role of tyrosine phosphatases MptpA and MptpB in the virulence and pathogenesis of Mycobacterium which can be used as potential targets for developing anti-tubercular drug.
    Type: Application
    Filed: July 9, 2004
    Publication date: August 27, 2009
    Applicants: Indian Council of Medical Research, University of Delhi
    Inventors: Anil Kumar Tyagi, Ramandeep Singh, Vivek Rao, Vadakkuppattu Devasenapathi Ramanathan, Chinnambedy Nainarappan Paramasivan, Paranji Ramaiyenger Narayanan, Yogendra Singh