Patents by Inventor Parichehr Malherbe

Parichehr Malherbe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterofused piperidines as orexin antagonists
    Patent number: 8067598
    Abstract: The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: November 29, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • Aminoamides as orexin antagonists
    Patent number: 7829563
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: November 9, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • 3-methanesulfonylquinolines as GABAenhancers
    Patent number: 7728142
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the specification, which are active at the GABAB receptor and which can be used for the treatment of CNS disorders.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: June 1, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Eric Prinssen
  • Quinolines as allosteric enhancers of the GABAreceptors
    Patent number: 7576217
    Abstract: The present invention relates to compounds of formula I wherein R1 to R6 are as described herein, which compounds are active at the GABAB receptor and can be used for the preparation of medicaments useful in the treatment of CNS disorders comprising anxiety and depression.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: August 18, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Hasane Ratni, Andrew William Thomas
  • 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
    Patent number: 7504428
    Abstract: The present invention a method of treating anxiety by administering compounds that are active on the GABAB receptor, having formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: March 17, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Eric Prinssen
  • Malonamides as orexin antagonists
    Patent number: 7501541
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: March 10, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • MALONAMIDES AS OREXIN ANTAGONISTS
    Publication number: 20080249180
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
    Type: Application
    Filed: March 7, 2008
    Publication date: October 9, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • HETEROCYCLIC DERIVATIVES AS OREXIN ANTAGONISTS
    Publication number: 20080249125
    Abstract: The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 9, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES
    Publication number: 20080234356
    Abstract: The present invention a method of treating anxiety by administering compounds that are active on the GABAB receptor, having formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims.
    Type: Application
    Filed: May 30, 2008
    Publication date: September 25, 2008
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Eric Prinssen
  • AMINOAMIDES AS OREXIN ANTAGONISTS
    Publication number: 20080221166
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
    Type: Application
    Filed: February 27, 2008
    Publication date: September 11, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
    Patent number: 7396853
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: July 8, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Eric Prinssen
  • Thieno-pyridine derivatives as allosteric enhancers of the GABAreceptors
    Patent number: 7390903
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compounds of the invention are active on the GABAB receptor and are useful for treating a variety of CNS disorders, including anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity-and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders and gastro-intestinal disorders.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: June 24, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Hasane Ratni, Andrew William Thomas
  • 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
    Publication number: 20070027204
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.
    Type: Application
    Filed: July 25, 2006
    Publication date: February 1, 2007
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger Norcross, Eric Prinssen
  • 3-Methanesulfonylquinolines as GABAB enhancers
    Publication number: 20060276469
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the specification, which are active at the GABAB receptor and which can be used for the treatment of CNS disorders.
    Type: Application
    Filed: June 1, 2006
    Publication date: December 7, 2006
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger Norcross, Eric Prinssen
  • Thieno-pyridine derivatives as allosteric enhancers of the GABAB receptors
    Publication number: 20060135552
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compounds of the invention are active on the GABAB receptor and are useful for treating a variety of CNS disorders, including anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity-and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders and gastrointestinal disorders.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 22, 2006
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger Norcross, Hasane Ratni, Andrew Thomas
  • Quinolines as allosteric enhancers of the GABAB receptors
    Publication number: 20060094754
    Abstract: The present invention relates to compounds of formula I wherein R1 to R6 are as described herein, which compounds are active at the GABAB receptor and can be used for the preparation of medicaments useful in the treatment of CNS disorders comprising anxiety and depression.
    Type: Application
    Filed: October 27, 2005
    Publication date: May 4, 2006
    Inventors: Parichehr Malherbe, Raffaello Masciadri, Roger Norcross, Hasane Ratni, Andrew Thomas