Patents by Inventor Parisa Malekzadeh

Parisa Malekzadeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T cell receptors recognizing mutated P53
    Patent number: 11939365
    Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 26, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Drew C. Deniger, Steven A. Rosenberg, Anna Pasetto, Rami Yoseph, Winifred M. Lo, Yong-Chen Lu, Maria R. Parkhurst, Paul F. Robbins, Parisa Malekzadeh
  • T CELL RECEPTORS RECOGNIZING R175H OR Y220C MUTATION IN P53
    Publication number: 20220332785
    Abstract: Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R175H or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 20, 2022
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Drew C. Deniger, Parisa Malekzadeh, Steven A. Rosenberg, Anna Pasetto
  • METHODS OF ISOLATING T CELLS HAVING ANTIGENIC SPECIFICITY FOR A P53 CANCER-SPECIFIC MUTATION
    Publication number: 20200316121
    Abstract: Disclosed are methods of isolating T cells having antigenic specificity for a mutated p53 amino acid sequence encoded by a cancer-specific p53 mutation, the method comprising: inducing autologous APCs of the patient to present the mutated p53 amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated p53 amino acid sequence; and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
    Type: Application
    Filed: September 17, 2018
    Publication date: October 8, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Drew C. Deniger, Steven A. Rosenberg, Parisa Malekzadeh
  • T CELL RECEPTORS RECOGNIZING MUTATED P53
    Publication number: 20200277352
    Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
    Type: Application
    Filed: September 17, 2018
    Publication date: September 3, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Drew C. Deniger, Steven A. Rosenberg, Anna Pasetto, Rami Yoseph, Winifred M. Lo, Yong-Chen Lu, Maria R. Parkhurst, Paul F. Robbins, Parisa Malekzadeh