Patents by Inventor Parker JOHNSON
Parker JOHNSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141007Abstract: The present disclosure relates to cleavable carriers and cleavable carrier-linked cytokine prodrugs wherein the cleavable carrier is an engineered Fc domain comprising at least one tumor-associated protease cleavage site. Upon cleavage at the cleavage site of the carrier Fc domain, the cytokine is released from a masking moiety. The platform provides enzymatically induced prodrug activation. The present disclosure further provides pharmaceutical compositions comprising said cleavable carrier-linked cytokine prodrugs, their use as a medication as well as methods of treatment of diseases and administration.Type: ApplicationFiled: July 14, 2023Publication date: May 2, 2024Inventors: Ertan Eryilmaz, Carl Uli Bialucha, Parker Johnson, Dheeraj Tomar
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Patent number: 11866476Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: GrantFiled: December 28, 2022Date of Patent: January 9, 2024Assignee: Xilio Development, Inc.Inventors: Margaret Karow, Deborah Moore Lai, Dheeraj Tomar, Parker Johnson, Raphael Rozenfeld, Ronan O'Hagan, Huawei Qiu
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Patent number: 11827686Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: GrantFiled: June 4, 2021Date of Patent: November 28, 2023Assignee: Xilio Development, Inc.Inventors: Margaret Karow, Deborah Moore Lai, Dheeraj Singh Tomar, Parker Johnson, Raphael Rozenfeld, Ronan O'Hagan, Huawei Qiu
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Patent number: 11827685Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: GrantFiled: June 4, 2021Date of Patent: November 28, 2023Assignee: Xilio Development, Inc.Inventors: Margaret Karow, Deborah Moore Lai, Dheeraj Singh Tomar, Parker Johnson, Raphael Rozenfeld, Ronan O'Hagan, Huawei Qiu
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Publication number: 20230365641Abstract: The present invention relates to targeted, masked cytokines, comprising a cytokine or functional fragment thereof, a masking moiety, a targeting moiety and a proteolytically cleavable linker. The targeting moiety comprises an antigen-binding moiety that specifically binds to an antigen expressed on the surface of a target cell The masking moiety masks the cytokine or functional fragment thereof thereby reducing or preventing binding of the cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.Type: ApplicationFiled: February 28, 2023Publication date: November 16, 2023Inventors: Parker Johnson, Ertan Eryilmaz, Dheeraj Tomar, Benjamin Nicholson, Kurt Jenkins, Carl Uli Bialucha
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Publication number: 20230331799Abstract: The present invention relates to masked IL-15 cytokines, comprising an IL-15 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-15 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-15 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.Type: ApplicationFiled: March 31, 2021Publication date: October 19, 2023Inventors: Raphael ROZENFELD, Ugur ESKIOCAK, Huawei QIU, Parker JOHNSON, Kurt Allen JENKINS, Magali PEDERZOLI-RIBEIL, Dheeraj Singh TOMAR, Rebekah Kay O'DONNELL
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Patent number: 11718655Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: GrantFiled: April 8, 2022Date of Patent: August 8, 2023Assignee: XILIO DEVELOPMENT, INC.Inventors: Margaret Karow, Deborah Moore Lai, Dheeraj Tomar, Parker Johnson, Raphael Rozenfeld, Ronan O'Hagan, Huawei Qiu
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Publication number: 20230235006Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: December 28, 2022Publication date: July 27, 2023Applicant: Xilio Development, Inc.Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU
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Publication number: 20230159603Abstract: The present invention relates to masked IL-12 cytokines, comprising an IL-12 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-12 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-12 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.Type: ApplicationFiled: March 31, 2021Publication date: May 25, 2023Inventors: Raphael ROZENFELD, Ugur ESKIOCAK, Huawei QIU, Parker JOHNSON, Kurt Allen JENKINS, Magali PEDERZOLI-RIBEIL, Dheeraj Singh TOMAR, Rebekah Kay O'DONNELL
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Publication number: 20230151072Abstract: The present invention relates to masked IL-2 cytokines, comprising an IL-2 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-2 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-2 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.Type: ApplicationFiled: March 31, 2021Publication date: May 18, 2023Inventors: Raphael ROZENFELD, Ugur ESKIOCAK, Huawei QIU, Parker JOHNSON, Kurt Allen JENKINS, Magali PEDERZOLI-RIBEIL, Dheeraj Singh TOMAR, Rebekah Kay O'DONNELL
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Publication number: 20230072822Abstract: The present disclosure provides tumor-specific cleavable linkers and their use in drugs and prodrugs for delivering therapeutics to a tumor cell environment. The present disclosure also provides cleavage products of said drugs and prodrugs, and methods related to the use of the same.Type: ApplicationFiled: November 24, 2021Publication date: March 9, 2023Inventors: Raphael ROZENFELD, Ugur ESKIOCAK, Huawei QIU, Parker JOHNSON, Kurt Allen JENKINS, Magali PEDERZOLI-RIBEIL, Dheeraj Singh TOMAR, Rebekah Kay O'DONNELL
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Publication number: 20230030037Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: June 4, 2021Publication date: February 2, 2023Applicants: Xilio Development, Inc., Xilio Development, Inc.Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj Singh TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU
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Publication number: 20230028959Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: June 4, 2021Publication date: January 26, 2023Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj Singh TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU
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Publication number: 20220306716Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: April 8, 2022Publication date: September 29, 2022Applicant: Xilio Development, Inc.Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU
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Publication number: 20220002370Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e.g., masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: September 27, 2019Publication date: January 6, 2022Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU
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Patent number: 11053294Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e g masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: GrantFiled: August 25, 2020Date of Patent: July 6, 2021Assignee: Xilio Development, Inc.Inventors: Margaret Karow, Deborah Moore Lai, Dheeraj Singh Tomar, Parker Johnson, Raphael Rozenfeld, Ronan O'Hagan, Huawei Qiu
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Publication number: 20210002343Abstract: Provided herein are cytokines or functional fragments thereof that, in some embodiments, are engineered to be masked by a masking moiety at one or more receptor binding site(s) of the cytokine or functional fragment thereof. In some embodiments, the cytokines are engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. In some embodiments, the proteolytically cleavable linker links the cytokine to the masking moiety, links the cytokine to a half-life extension domain, and/or links the masking moiety to a half-life extension domain. The masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e g masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the cytokine becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.Type: ApplicationFiled: August 25, 2020Publication date: January 7, 2021Inventors: Margaret KAROW, Deborah Moore LAI, Dheeraj Singh TOMAR, Parker JOHNSON, Raphael ROZENFELD, Ronan O'HAGAN, Huawei QIU