Patents by Inventor Parker SULKOWSKI

Parker SULKOWSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for targeting cancers
    Patent number: 11311538
    Abstract: In various aspects and embodiments the invention provides a method of treating or preventing a cancer in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of a DNA repair inhibitor, a DNA strand break repair inhibitor, and a homologous recombination (HR) repair inhibitor, wherein cells in the cancer comprise a fumarate hydratase (FH) and/or succinate dehydrogenase (SDH) mutation.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: April 26, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Ranjit Bindra, Peter Glazer, Parker Sulkowski, Brian Shuch
  • Compositions and Methods For Targeting Cancers
    Publication number: 20200016156
    Abstract: In various aspects and embodiments the invention provides a method of treating or preventing a cancer in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of a DNA repair inhibitor, a DNA strand break repair inhibitor, and a homologous recombination (HR) repair inhibitor, wherein cells in the cancer comprise a fumarate hydratase (FH) and/or succinate dehydrogenase (SDH) mutation.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 16, 2020
    Inventors: Ranjit Bindra, Peter Glazer, Parker Sulkowski, Brian Shuch
  • Compositions and methods for targeting and treating homologous recombination-deficient tumors
    Publication number: 20190133980
    Abstract: The invention includes compositions and methods for treating or preventing a cancer in a subject. In one aspect the invention provides methods of administering to a subject suffering from a cancer with cells containing an IDH1 or IDH2 mutation, at least one compound comprising a DNA repair inhibitor. The invention also provides methods of treating a cancer with 2 HG, a derivative of 2-HG, any variant and any mixtures thereof. In one aspect the invention provides a pharmaceutical composition comprising an anti-tumor effective mount of at least one compound selected from the group consisting of 2-hydroxyglutarate (2-HG), a derivative of 2-HG, any variant and any mixtures thereof.
    Type: Application
    Filed: June 2, 2017
    Publication date: May 9, 2019
    Inventors: Ranjit BINDRA, Peter GLAZER, Nathaniel ROBINSON, Parker SULKOWSKI, Christopher CORSO