Patents by Inventor Parthasarathy CHANDRAKESAN

Parthasarathy CHANDRAKESAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RADIATION MITIGATOR AND METHOD OF USE THEREOF
    Publication number: 20230310407
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
    Type: Application
    Filed: June 8, 2023
    Publication date: October 5, 2023
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • Radiation mitigator and method of use thereof
    Patent number: 11672789
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: June 13, 2023
    Assignees: Georgetown University, The Board of Regents of the University of Oklahoma
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • Anti-doublecortin-like kinase 1 antibodies and methods of use
    Patent number: 11655307
    Abstract: Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 23, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Courtney W. Houchen, Nathaniel Weygant, Dongfeng Qu, Randal May, Parthasarathy Chandrakesan, William L. Berry
  • RADIATION MITIGATOR AND METHOD OF USE THEREOF
    Publication number: 20230033749
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
    Type: Application
    Filed: April 25, 2022
    Publication date: February 2, 2023
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • Radiation mitigator and method of use thereof
    Patent number: 11311526
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 26, 2022
    Assignees: Georgetown University, The Board of Regents of the University of Oklahoma
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • ANTI-DOUBLECORTIN-LIKE KINASE 1 ANTIBODIES AND METHODS OF USE
    Publication number: 20210189007
    Abstract: Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.
    Type: Application
    Filed: May 30, 2018
    Publication date: June 24, 2021
    Inventors: Courtney W. Houchen, Nathaniel WEYGANT, Dongfeng QU, Randal MAY, Parthasarathy CHANDRAKESAN, William L. BERRY
  • RADIATION MITIGATOR AND METHOD OF USE THEREOF
    Publication number: 20200306234
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O—or —N(H)—.
    Type: Application
    Filed: March 31, 2017
    Publication date: October 1, 2020
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • MICRORNA EXPRESSION SIGNATURES FOR DOUBLECORTIN-LIKE KINASE 1 (DCLK1) ACTIVITY
    Publication number: 20190218603
    Abstract: Primer and/or probe sets and arrays for determining microRNA (miRNA) expression signatures that are specific to doublecortin-like kinase 1 (DCLK1) activity, and methods of their use, are disclosed.
    Type: Application
    Filed: May 18, 2017
    Publication date: July 18, 2019
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Courtney W. HOUCHEN, Nathaniel WEYGANT, Dongfeng QU, Randal MAY, Parthasarathy CHANDRAKESAN