Patents by Inventor Paruchuri Gangadhar Rao
Paruchuri Gangadhar Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150328170Abstract: The present invention relates to a synergistic pharmaceutical composition comprising Compound C2 (Neo-isopulegol), C3 (Iso-pulegol) and C4 (Citronellol) derived from herbal seed extract of Litsea cubeba useful for the treatment of lung cancer. The present invention also relates to the activity of compounds C2 or C3 or C4 either alone or in combination in killing of A549 lung cancer cells.Type: ApplicationFiled: September 5, 2012Publication date: November 19, 2015Applicants: Visva-Bharati, Council of Scientific & Industrial ResearchInventors: Mantu Bhuyan, Pranab Ram Bhattacharyya, Pranab Kumar Baruah, Nabin Chandra Barua, Paruchuri Gangadhar Rao, Sushmita Bhattacharya, Rakesh Kundu, Priyajit Chatterjee, Soma Seal, Sandeep Mukherjee, Suman Dasgupta, Sudipta Moitra, Shelley Bhattacharya, Samir Bhattacharya
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Patent number: 8912357Abstract: This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and pericarps). Yield is 12-18% w/w. Shikimic acid is useful as raw material for the production of oseltavir (Tamiflu) used against Avian Flu. It is also reported that its triacyl derivatives can inhibit blood platelet assembling and Thrombosis by affecting the metabolism of Arachidonic acid. Hitherto known commercial methods of production of shikimic acid from the fruits of star anise (Illicium verum) and sweet gum (Liquidambar styraciflua) gives only 3-7% and 1.5% respectively. The price of shikimic acid in the international market varies from US$ 45.00 to 1000.00 per Kg depending on demand. Further as per report published at the website www.livemint.com, China Government has imposed restriction on export of shikimic acid.Type: GrantFiled: March 9, 2011Date of Patent: December 16, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Manobjyoti Bordoloi, Jayanta Borah, Dipak Kumar Roy, Subhash Chandra Dutta, Nabin Chandra Baruah, Paruchuri Gangadhar Rao
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Patent number: 8841466Abstract: This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2-[10??-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalized artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines.Type: GrantFiled: January 20, 2011Date of Patent: September 23, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Gakul Baishya, Nabin Chandra Barua, Abhishek Goswami, Partha Pratim Saikia, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri, Madhunika Sharma
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Patent number: 8680288Abstract: The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.Type: GrantFiled: July 20, 2011Date of Patent: March 25, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Jadab Chandra Sarma, Dilip Chandra Bora, Paruchuri Gangadhar Rao, Balaram Ghosh, Sakshi Balwani
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Publication number: 20130331581Abstract: The present invention relates to 1,2,3-triazole containing artemisinin compounds and process for preparation thereof. Described herein is the synthesis, bioassay results and usefulness of the artemisinin derived compounds resulting from 1,3-di-polar cycloaddition reaction of artemisinin derived azide or alkyne with aliphatic or aromatic diazides. These 1,2,3-triazole containing artemisinin derived compounds embodied in this document are found to be active against various cancer cell-lines.Type: ApplicationFiled: February 14, 2012Publication date: December 12, 2013Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Bishwajit Saikia, Nabin Chandra Barua, Partha Pratim Saikia, Abhishek Goswami, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri
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Patent number: 8513226Abstract: The present invention relates to preparation and biological evaluation of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2?-chloro-5-androsteno[17,16-b]pyridine (5) as gastric proton pump inhibitor and their comparison to that of omeprazole, a clinically employed anti-gastric ulcer drug. Compound (4) exhibited dose dependent inhibition of histamine-stimulated acid secretion in gastric parietal cell with an IC50 value comparable to cimetidine. No mortality or behavioral abnormality of Swiss albino mice was observed under single-dose level of 1 g/Kg body weight of compound (4). Compound (4) further exhibited excellent anti ulcer activity in vivo against indomethacin induced ulcer.Type: GrantFiled: March 26, 2009Date of Patent: August 20, 2013Assignee: Council of Scientific and Industrial ResearchInventors: Romesh Chandra Boruah, Moyurima Borthakur, Madan Gopal Barthakur, Paruchuri Gangadhar Rao, Sudip Kumar Kar, Annalakshmi Chinniah, Suchandra Goswami, Pratap Kumar Das
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Publication number: 20130137895Abstract: This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and pericarps). Yield is 12-18% w/w. Shikimic acid is useful as raw material for the production of oseltavir (Tamiflu) used against Avian Flu. It is also reported that its triacyl derivatives can inhibit blood platelet assembling and Thrombosis by affecting the metabolism of Arachidonic acid. Hitherto known commercial methods of production of shikimic acid from the fruits of star anise (Illicium verum) and sweet gum (Liquidambar styraciflua) gives only 3-7% and 1.5% respectively. The price of shikimic acid in the international market varies from US$ 45.00 to 1000.00 per Kg depending on demand. Further as per report published at the website www.livemint.com, China Government has imposed restriction on export of shikimic acid.Type: ApplicationFiled: March 9, 2011Publication date: May 30, 2013Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Manobjyoti Bordoloi, Jayanta Borah, Dipak Kumar Roy, Subhash Chandra Dutta, Nabin Chandra Baruah, Paruchuri Gangadhar Rao
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Publication number: 20130131350Abstract: The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.Type: ApplicationFiled: July 20, 2011Publication date: May 23, 2013Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Jadab Chandra Sarma, Dilip Chandra Bora, Paruchuri Gangadhar Rao, Balaram Ghosh, Sakshi Balwani
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Publication number: 20130030044Abstract: This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2[10??-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin.Type: ApplicationFiled: January 20, 2011Publication date: January 31, 2013Applicant: Council of Scientific & Industrial ResearchInventors: Gakul Baishya, Nabin Chandra Barua, Abhishek Goswami, Partha Pratim Saikia, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri, Madhunika Sharma
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Publication number: 20110028440Abstract: The present invention relates to preparation and biological evaluation of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2?-chloro-5-androsteno[17,16-b]pyridine (5) as gastric proton pump inhibitor and their comparison to that of omeprazole, a clinically employed anti-gastric ulcer drug. Compound (4) exhibited dose dependent inhibition of histamine-stimulated acid secretion in gastric parietal cell with an IC50 value comparable to cimetidine. No mortality or behavioral abnormality of Swiss albino mice was observed under single-dose level of 1 g/Kg body weight of compound (4). Compound (4) further exhibited excellent anti ulcer activity in vivo against indomethacin induced ulcer.Type: ApplicationFiled: March 26, 2009Publication date: February 3, 2011Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Romesh Chandra Boruah, Moyurima Borthkur, Madan Gopal Barthakur, Paruchuri Gangadhar Rao, Sudip Kumar Kar, Annalaxmi Chinniah, Suchandra Goswami, Pratap Kumar Das
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Patent number: 6935144Abstract: An improved device for leather processing comprising a vessel containing perforated dummy doors and compartments with pegs as well as friction disk fixed along the exterior periphery of the vessel. The leathers to be wet processed are subjected to mechanical action in terms of both rocking action as well as rotational movement simultaneously. The perpetual motion of the device help to create pressure generation for quickening the process and for addition of chemical solution continuously. The processing takes place under pressure generated inside the vessel and with the support of multiple mechanical actions, resulting in higher exhaustion of bath with less processing time and energy requirement and higher capacity utilization to produce good quality leather.Type: GrantFiled: March 20, 2003Date of Patent: August 30, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Duraiswamy Lakshmanan, Bommya Thangaraj, Subramaniyam Krishnan, Natesan Samivelu, Paruchuri Gangadhar Rao, Thirumalachari Ramasami
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Publication number: 20040182118Abstract: An improved device for leather processing comprising a vessel containing perforated dummy doors and compartments with pegs as well as friction disk fixed along the exterior periphery of the vessel. The leathers to be wet processed are subjected to mechanical action in terms of both rocking action as well as rotational movement simultaneously. The perpetual motion of the device help to create pressure generation for quickening the process and for addition of chemical solution continuously. The processing takes place under pressure generated inside the vessel and with the support of multiple mechanical actions, resulting in higher exhaustion of bath with less processing time and energy requirement and higher capacity utilization to produce good quality leather.Type: ApplicationFiled: March 20, 2003Publication date: September 23, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Duraiswamy Lakshmanan, Bommya Thangaraj, Subramaniyam Krishnan, Natesan Samivelu, Paruchuri Gangadhar Rao, Thirumalachari Ramasami