Abstract: A device, system and components configured to be inserted or imbedded in an oral cavity of an animal or human for oral mucosa drug delivery system, OMDDS. The device includes a receptacle for one or more OMDDS with or without enhancer for drug delivery. The enhancer can assist in delivery via non-invasive or minimally invasive active or passive mythologies. The device is configured for several diseases including local and systemic disease. The device can replace invasive injections while reducing patient discomfort and pain. The device can be further configured to interface a plurality of one or more customizable functions and applications; including, but not limited to, auxiliary body biosensors, closed loop diagnosis and medication administration, data collections, alerting, reporting, communication network, preset biometrics and dose ranges. The system includes technology-integration, analytics, and wearables to accurately determine health referred to communication network of wearable drug delivery system.