Patents by Inventor Pascal Andre Stein

Pascal Andre Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CD19 antibodies with reduced immunogenicity
    Patent number: 11208496
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: December 28, 2021
    Assignee: Cancer Research Technology LTD.
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • ANTI-CD19 ANTIBODIES WITH REDUCED IMMUNOGENICITY
    Publication number: 20190241671
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Application
    Filed: September 10, 2018
    Publication date: August 8, 2019
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • Methods of use of anti-CD19 antibodies with reduced immunogenicity
    Patent number: 10072092
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: September 11, 2018
    Assignee: Merck Patent GmbH
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • METHODS OF USE OF ANTI-CD19 ANTIBODIES WITH REDUCED IMMUNOGENICITY
    Publication number: 20150322159
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Application
    Filed: February 12, 2015
    Publication date: November 12, 2015
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • DNA encoding IL-2 fusion proteins with modulated selectivity
    Patent number: 7888071
    Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: February 15, 2011
    Assignee: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Pascal Andre Stein, Kin-Ming Lo