Abstract: According to an aspect, there is provided a wearable device, the wearable device comprising: an inflatable body configured to be mounted to a torso of a user; a first sensing device, wherein the first sensing device comprises a first sensor and a first actuator coupling the first sensor to the inflatable body; and a memory storing computer-readable instructions that, when executed, cause the wearable device to: inflate the inflatable body from a first state of the inflatable body to a second state of the inflatable body; actuate the first actuator from a first state of the first actuator to a second state of the first actuator, wherein actuating the first actuator from the first state of the first actuator to the second state of the first actuator reduces a volume of a first air gap between the torso and the first sensor; and while the inflatable body is in the second state of the inflatable body and the first actuator is in the second state of the first actuator receive a first signal from the first sensor.

Abstract: An acoustic sensing system is provided for monitoring sounds including sounds from a subject's airway. An acoustic sensor generates an acoustic signal, and a pressure or flow sensor generates a pressure or flow signal relating to the subject's airway. The acoustic signal and the pressure or flow signal are processed to identify secretions. In one aspect, the acoustic signal is processed to filter out sounds associated with the secretions. In another aspect, for each identified secretion, a type is identified from a plurality of different secretion types.

Abstract: A respiratory support device for providing pressurized air to a subject. The respiratory support device comprises a conduit, an acoustic sensor, a membrane, and a body. The conduit is for conveying an airflow. The conduit has an opening. The acoustic sensor is arranged outside the conduit. The membrane is arranged to cover the opening to separate the acoustic sensor and the airflow from each other. The body is attached to the membrane. The body is adapted to vibrate in response to sound propagating along the airflow. The acoustic sensor is adapted to generate a signal representative of the sound based on a vibration of the body.

Abstract: A system for managing mechanical ventilation provided to a patient by a ventilator. The system includes a plurality of electrodes for being adhered to the patient's chest and a controller in communication with the plurality of electrodes, the controller being programmed to determine from signals received from the electrodes metrics of the patient including: a measure of breathing effort of the patient, and one or both of a heart rate of the patient and/or a respiration rate of the patient. The system further includes a user interface in communication with the controller. The controller is adapted to communicate the metrics to the user interface which is adapted to receive and concurrently display a representation of the measure of breathing effort of the patient on the display; and/or control operation of the ventilator and utilize the measure of breathing effort of the patient in a control algorithm governing such operation.

Abstract: A streamlined system for non-invasively determining a neural respiratory drive (NRD) index of a patient includes an EMG patch that provides three integrated EMG electrodes: two signal EMG electrodes to be positioned in the second intercostal space on either side of the sternum and one reference EMG electrode to be positioned on the sternum above the two signal electrodes. The integration of all three EMG electrodes in a single patch enables clinicians to spend less time determining where to place the patch than they would if they had to determine the proper positioning of three single EMG electrodes. In addition, the disclosed system provides a single cable that can electrically connect to all three EMG electrodes when inserted into a plug on the EMG patch, thereby reducing cable clutter that would otherwise result from having to provide a separate cable for each EMG electrode.

Abstract: A therapy system has a nasal cannula patient interface configured to deliver gas to a nasal cavity of a patient and a delivery system for delivering oxygen-enriched breathing gas, comprising air and enrichment oxygen, to the patient interface. A sensor is provided allowing arterial partial pressure of CO2, PaCO2 to be measured or estimated thereby to generate capnograph data, A parameter is determined from the capnograph data which is representative of CO2 washout, and the total flow rate, the oxygen flow rate or the air flow rate of the breathing gas delivered by the delivery system are iteratively adjusted while monitoring the determined parameter. A value of total flow rate, oxygen flow rate or air flow rate is used which maximizes CO2 washout or achieves a desired level of CO2 washout.

Abstract: According to an aspect, there is provided a cannula for use in high flow nasal therapy, comprising: a first tube for directing a first fluid from a nasal cavity of a subject to a location outside of the subject; a second tube for directing a second fluid from a supply of the second fluid to the nasal cavity of the subject; a flow sensor located within the first tube, the flow sensor configured to measure a flow rate of the first fluid moving through the first tube; and a humidity sensor located within the first tube, the humidity sensor configured to measure a humidity of the first fluid moving through the first tube; wherein the measured flow rate and the measured humidity are to be used by a processor to control a humidifier to adjust a humidity of the second fluid to be supplied to the subject.

Abstract: Provided are concepts for controlling a high flow nasal therapy (HFNT) device used by a subject. In particular, physiological and movement parameter values of the subject are leveraged in order to generate a control signal for the HFNT device. These parameters may indicate an activity level of the subject, as well as the condition of the subject, providing information useful for setting appropriate operating conditions of the HFNT device. Thus, a means for automatically controlling a HFNT device based on needs of the subject may be provided, improving subject comfort during therapy, and ease of use of the HFT device.

Abstract: According to an aspect, there is provided a ventilator system. The ventilator system comprises: a mouthpiece, to be received within a user's mouth, wherein the mouthpiece comprises: a passage for permitting a flow of gases through the mouthpiece between a first side of the passage to be inside the user's mouth and a second side of the passage to be outside the user's mouth; a passage adjustment component for selectively adjusting a flow area of the passage; and one or more sensors mounted on the mouthpiece, wherein the sensors comprise a pressure sensor configured to measure a pressure at the first side of the passage; and a controller configured to control: a flow rate and/or concentration of oxygen supplied to the user through a nasal cannula; a total flow rate of air and oxygen supplied through the nasal cannula; and/or the flow area of the passage, based on the pressure measured by the pressure sensor.

Abstract: Provided are concepts for generating an indicator of chronic obstructive pulmonary disease (COPD) in a subject. In particular, data from a plurality of sensors, including a pressure sensor, an airflow sensor, and a CO2 concentration sensor is captured from the breath of the subject received by a mouthpiece. The sensor data is then utilised by a processing unit to generate an indicator of COPD in the subject. By utilising airway pressure, airway flow rate and expiratory CO2 concentration data, an accurate indicator of the presence and/or stage of COPD may be obtained.

Abstract: The present invention provides a system (10) for humidification of a pressurized flow of breathable gas delivered to a patient, the system comprising; a ventilator (12) for generating a pressurized flow of breathable gas; a patient circuit (14) in fluid communication with the ventilator and connectable to the respiratory system of a patient; and an aerosol generator (18). The patient circuit defines an internal space (26) for transporting the flow of breathable gas which internal space accommodates the outflow opening (20) of the aerosol generator. This enables to prevent so-called rainout and a relatively light weight portable system. The invention also relates to an insert (30) that is connectable to the patient circuit and that accommodates the aerosol generator.

Abstract: A system is for analyzing physical characteristics of mucus, in particular during patient respiratory support using a ventilator. A ventilation waveform is sensed and analyzed and an estimate of, or a change in, at least one mucus characteristic can then be determined.

Abstract: The invention provides a positive airway pressure therapy system comprising a positive pressure generation unit, adapted to generate a positive pressure airflow for provision to a subject, and an oscillatory pressure generation unit adapted to modulate the positive pressure airflow at a modulation frequency thereby imparting a frequency component to the positive pressure air flow. The oscillatory pressure generation unit is adapted to modulate the airflow during an exhalation phase of a breathing cycle of the subject.

Abstract: According to an aspect, there is provided a wearable device, the wearable device comprising: an inflatable body configured to be mounted to a torso of a user; a first sensing device, wherein the first sensing device comprises a first sensor and a first actuator coupling the first sensor to the inflatable body; and a memory storing computer-readable instructions that, when executed, cause the wearable device to: inflate the inflatable body from a first state of the inflatable body to a second state of the inflatable body; actuate the first actuator from a first state of the first actuator to a second state of the first actuator, wherein actuating the first actuator from the first state of the first actuator to the second state of the first actuator reduces a volume of a first air gap between the torso and the first sensor; and while the inflatable body is in the second state of the inflatable body and the first actuator is in the second state of the first actuator receive a first signal from the first sensor.

Abstract: The invention describes a laser sensor module (100) for detecting ultra-fine particles (10) with a particle size of 300 nm or less, more preferably 200 nm or less, most preferably 100 nm or less, the laser sensor module (100) comprising: —at least one laser (110) being adapted to emit laser light to at least one focus region in reaction to signals provided by at least one electrical driver (130), —at least one detector (120) being adapted to determine a self-mixing interference signal of an optical wave within a laser cavity of the at least one laser (110), wherein the self-mixing interference signal is caused by reflected laser light reentering the laser cavity, the reflected laser light being reflected by a particle receiving at least a part of the laser light, —the laser sensor module (100) being arranged to perform at least one self-mixing interference measurement, —the laser sensor module (100) being adapted to determine a first particle size distribution function with a first sensitivity by means of at

Abstract: The invention describes a laser sensor module (100) for detecting ultra-fine particles (10) with a particle size of 300 nm or less, more preferably 200 nm or less, most preferably 100 nm or less, the laser sensor module (100) comprising: —at least one laser (110) being adapted to emit laser light to at least one focus region in reaction to signals provided by at least one electrical driver (130),—at least one detector (120) being adapted to determine a self-mixing interference signal of an optical wave within a laser cavity of the at least one laser (110), wherein the self-mixing interference signal is caused by reflected laser light reentering the laser cavity, the reflected laser light being reflected by a particle receiving at least a part of the laser light,—the laser sensor module (100) being arranged to perform at least one self-mixing interference measurement,—the laser sensor module (100) being adapted to determine a first particle size distribution function with a first sensitivity by means of at lea

Abstract: The present invention provides a system (10) for humidification of a pressurized flow of breathable gas delivered to a patient, the system comprising; a ventilator (12) for generating a pressurized flow of breathable gas; a patient circuit (14) in fluid communication with the ventilator and connectable to the respiratory system of a patient; and an aerosol generator (18). The patient circuit defines an internal space (26) for transporting the flow of breathable gas which internal space accommodates the outflow opening (20) of the aerosol generator. This enables to prevent so-called rainout and a relatively light weight portable system. The invention also relates to an insert (30) that is connectable to the patient circuit and that accommodates the aerosol generator.

Abstract: An integrated circuit sensor array includes a semiconductor substrate; an insulating layer over the substrate; and a first transistor on the insulating layer. The first transistor includes an exposed functionalized channel region in between a source region and a drain region for sensing an analyte in a medium. The integrated circuit sensor array also includes a second transistor formed on the insulating layer, where the second transistor includes an exposed channel region between source and drain regions for sensing a potential of the medium. Further, a voltage bias generator is conductively coupled to the semiconductor substrate for providing the transistors with a bias voltage, the voltage bias generator being responsive to the second transistor.

Abstract: The invention describes a modular fluid sensing system comprising a fluid sensing terminal (150) and removable fluid channel units (101, 102, 103). The fluid channel units (101, 102, 103) comprise or can be combined with fluid treatment units as filters, sensors and seals. The fluid channel units (101, 102, 103) can be combined in accordance with the present needs of the user of the fluid sensing system. The invention therefore enables a reconfigurable channel system with reconfigurable measurement and treatment options within a fluid sensing system.

Abstract: Integrated circuit (100) sensor array, comprising a semiconductor substrate (110); an insulating layer (120) over said substrate; an first transistor (140a) on said insulating layer, the first transistor comprising an exposed functionalized channel region (146a) in between a source region (142a) and a drain region (144) for sensing an analyte in a medium; a second transistor (140b) on said insulating layer, the second transistor comprising an exposed channel region (146b) in between a source region (142b) and a drain region (144) for sensing a potential of said medium; and a voltage bias generator (150) conductively coupled to the semiconductor substrate for providing said transistors with a bias voltage, said voltage bias generator being responsive to the second transistor. A sensing apparatus comprising such an IC and an analyte measurement method using such an IC are also disclosed.