Patents by Inventor Pascal Dott

Pascal Dott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one compounds
    Patent number: 10538536
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: January 21, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Fabian Feyen, Stefan Hildbrand, Ursula Hoffmann, Fabienne Hoffmann-Emery, Roland Meier, Gerard Moine, Pankaj Rege, Georg Wuitschik
  • PROCESS FOR THE PREPARATION OF HU-910 AND CRYSTALLINE STRUCTURE THEREOF
    Publication number: 20190315669
    Abstract: The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.
    Type: Application
    Filed: November 13, 2017
    Publication date: October 17, 2019
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Jean-Michel ADAM, Pascal DOTT, Marcus HOHLER, Tanja BURGER, Orazio TAGLIENTE, Ernst MISCHLER
  • NOVEL PROCESS
    Publication number: 20190144468
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 16, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal DOTT, Fabian FEYEN, Stefan HILDBRAND, Ursula HOFFMANN, Fabienne HOFFMANN-EMERY, Roland MEIER, Gerard MOINE, Pankaj REGE, Georg WUITSCHIK
  • Solid forms
    Patent number: 8975397
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: March 10, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
  • NOVEL SOLID FORMS
    Publication number: 20140329806
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
    Type: Application
    Filed: June 4, 2014
    Publication date: November 6, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
  • Solid forms
    Patent number: 8785435
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 22, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
  • Process for the preparation of isoxazolyl-methoxy nicotinic acids
    Patent number: 8604062
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 10, 2013
    Assignee: Hoffman-La Roche Inc.
    Inventors: Pascal Dott, Steven Paul Hanlon, Stefan Hildbrand, Hans Iding, Andrew Thomas, Pius Waldmeier
  • PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES
    Publication number: 20120101282
    Abstract: The present invention relates to a process for the preparation of nicotinamide derivatives of formula I, wherein R1 to R7 are as defined above and to pharmaceutically acceptable salts thereof. The compounds of formula I are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of cannabinoid 1 receptors (CB1 receptors) as described in the PCT Publ. WO 2006/106054.
    Type: Application
    Filed: October 12, 2011
    Publication date: April 26, 2012
    Inventors: Pascal Dott, Pius Waldmeier
  • Processes for the manufacture of a pyrrolidine-3,4-dicarboxamide derivative
    Patent number: 7872141
    Abstract: The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), and the intermediates useful for those processes of manufacture.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: January 18, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel Adam, Pascal Dott, Hans Iding, Hans-Juergen Mair, Reinhard Reents, Beat Wirz
  • SOLID FORMS OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE
    Publication number: 20090215826
    Abstract: The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine-3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 27, 2009
    Inventors: Jean-Michel Adam, Andre Bubendorf, Annette Deynet-Vucenovic, Pascal Dott, Alexander Glomme, Olaf Grassmann, Wolfgang Haap, Martin Kuentz, Roland Meier
  • PROCESSES FOR THE MANUFACTURE OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE
    Publication number: 20080214826
    Abstract: The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), and the intermediates useful for those processes of manufacture.
    Type: Application
    Filed: December 19, 2007
    Publication date: September 4, 2008
    Inventors: Jean-Michel Adam, Pascal Dott, Hans Iding, Hans-Juergen Mair, Reinhard Reents, Beat Wirz