Patents by Inventor Pascal George

Pascal George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7476756
    Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: January 13, 2009
    Assignee: Sanofi-Aventis
    Inventors: Antonio Almario-Garcia, Pascal George, Christian Hoornaert, Adrien Tak Li, Frederic Puech
  • Patent number: 7294632
    Abstract: The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: November 13, 2007
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Pascal George, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20060025431
    Abstract: The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: September 7, 2005
    Publication date: February 2, 2006
    Applicants: Sanofi-Aventis, Mitsubishi Pharma Corportion
    Inventors: Pascal George, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 6895791
    Abstract: A clutch assembly for coupling a first spindle to a second spindle. The clutch assembly has a first disc connectable to the first spindle. A first finger is operatively coupled to the first disc and pivotable between a first engaged position and a first disengaged position. The first finger opposes rotation of the first disc in a first direction when the first finger is in the first engaged position. A second disc is connectable to the second spindle. The second disc pivots the first finger from the first engaged position to the first disengaged position when the second disc is rotated in the first direction through a first range of angular positions and rotates the first disk in the first direction when the second disc is rotated beyond the first range of angular positions.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: May 24, 2005
    Assignee: Onity, Inc.
    Inventors: Arnon Alexander, Andrew Weiman, Jonathan P. Payne, Pascal Georges Metivier
  • Publication number: 20040003633
    Abstract: A clutch assembly for coupling a first spindle to a second spindle. The clutch assembly has a first disc connectable to the first spindle. A first finger is operatively coupled to the first disc and pivotable between a first engaged position and a first disengaged position. The first finger opposes rotation of the first disc in a first direction when the first finger is in the first engaged position. A second disc is connectable to the second spindle. The second disc pivots the first finger from the first engaged position to the first disengaged position when the second disc is rotated in the first direction through a first range of angular positions and rotates the first disk in the first direction when the second disc is rotated beyond the first range of angular positions.
    Type: Application
    Filed: May 9, 2003
    Publication date: January 8, 2004
    Applicant: Onity, Inc.
    Inventors: Arnon Alexander, Andrew Weiman, Jonathan P. Payne, Pascal Georges Metivier
  • Patent number: 6221879
    Abstract: Compounds of general formula (I) in which U represents a group of general formula (A) or (B) in which formulae V represents a hydrogen or halogen atom, a (C1-C3)alkyl group or one or two (C1-C3)alkoxy groups, W and X each represent, respectively, either two oxygen atoms, or an oxygen atom and a CH2 group, or a CH2 group and an oxygen atom, or an oxygen atom and a CO group, n represents the number 0 or 1, R represents either a propyl group when U represents a group of general formula (A), or a hydrogen atom or a (C1-C3)alkyl group when U represents a group of general formula (B), Y represents one or more atoms or groups chosen from the following: hydrogen, halogen, (C1-C3)alkyl and (C1-C3)alkoxy, Z represents two hydrogen atoms or an oxygen atom.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: April 24, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Benoit Marabout, Mireille Sevrin, Pascal George, Jean-Pierre Merly, Daniele De Peretti, Jocelyne Roy, David Machnik
  • Patent number: 6075021
    Abstract: Compounds of general formula (I) ##STR1## in which the variables are as defined in the specification, their preparation and their application in therapeutics.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: June 13, 2000
    Assignee: Synthelabo
    Inventors: Yannick Evanno, Mireille Sevrin, Christian Maloizel, Odette Legalloudec, Pascal George
  • Patent number: 5929078
    Abstract: Compounds corresponding to the general formula (I): ##STR1## in which X represents a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkoxy group or a cyclopropylmethoxy group and Y represents a hydrogen atom, a hydroxyl group or a methoxy group and salts and bases thereof. The compounds may exists in the form of a pure enantiomer or as a mixture of enantiomers. Additionally, the compounds of formula (I) are useful for the treatment of diseases associated with serotoninergic receptors, particularly anxiety and/or depression.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: July 27, 1999
    Assignee: Synthelabo
    Inventors: Pascal George, Mireille Sevrin, Philippe Manoury, Michel Peynot, Daniele De Peretti, Jean Fran.cedilla.ois Gibert, Arlette Tixidre, David Machnik
  • Patent number: 5922739
    Abstract: Compounds of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkylmethyl or phenyl-(C.sub.1 -C.sub.3)alkyl group optionally substituted on the phenyl ring with one or more atoms or groups chosen from halogens and methyl, trifluoromethyl, methoxy and cyano groups, R.sub.2 represents a hydroxyl or alkoxy group or a group of general formula NR.sub.3 R.sub.4 in which R.sub.3 and R.sub.4 each represent a hydrogen atom, an alkyl group, a cycloalkyl group, a cycloalkylmethyl group, a phenyl group, a phenylmethyl group or a pyridyl group, or alternatively R.sub.3 and R.sub.4 form, together with the nitrogen atom, a pyrrolidine or piptzidine ring, and n represents the number 1, 2 or 3.Application in therapy.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: July 13, 1999
    Assignee: Synthelabo
    Inventors: Gihad Dargazanli, Yannick Evanno, Jonathan Frost, Patrick Lardenois, Mireille Sevrin, Pascal George
  • Patent number: 5663183
    Abstract: Compounds of the formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom or a methyl or C.sub.1 -C.sub.4 alkoxy group, R'.sub.1 represents a hydrogen or halogen atom, R".sub.1 represents a hydrogen atom or a methoxy group, R.sub.3 represents a C.sub.1 -C.sub.3 alkyl group, R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group, or R.sub.3 and R.sub.4 together form, with the adjacent nitrogen atom, a 1,2,3,4-tetrahydroisoquinol-2-yl, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetra-hydro-1H-3-benzazepin-3-yl, group are useful in the treatment of cerebral disorders.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: September 2, 1997
    Assignee: Synthelabo
    Inventors: Jonathan Frost, Pascal George, Patrick Pasau, Regine Bartsch, Corinne Rousselle, Paul Howard Williams, Jean Claude Muller
  • Patent number: 5652248
    Abstract: Eliprodil, or an enantiomer thereof, is indicated for combined administration with anticancer agents in order to prevent peripheral neuropathies induced by administration of the anticancer agents.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: July 29, 1997
    Assignee: Synthelabo
    Inventors: Delphine Lekieffre, Jesus Benavides, Bernard Scatton, Pascal George
  • Patent number: 5550125
    Abstract: Compounds of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen, fluorine or chlorine atom or a methyl, C.sub.1 -C.sub.3 alkoxy or nitro group; R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group; or alternatively R.sub.3 and R.sub.4 complete, with the nitrogen atom to which they are attached, a 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 4,5,6,7-tetrahydrothieno[3,2-c]pyrid-6-yl or 2,3-dihydro-1H-isoindol-2-yl group; are useful for the treatment and prevention of cerebral disorders.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: August 27, 1996
    Assignee: Synthelabo
    Inventors: Pascal George, Jonathan Frost, Patrick Pasau, Corinne Rousselle, R egine Bartsch, Paul Howard Williams, Jean Claude Muller
  • Patent number: 5550162
    Abstract: Compounds of the formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom or a methyl or C.sub.1 -C.sub.4 alkoxy group, R'.sub.1 represents a hydrogen or halogen atom, R".sub.1 represents a hydrogen atom or a methoxy group, R.sub.3 represents a C.sub.1 -C.sub.3 alkyl group, R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group, or R.sub.3 and R.sub.4 together form, with the adjacent nitrogen atom, a 1,2,3,4-tetrahydroisoquinol-2-yl, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetra-hydro-1H-3-benzazepin-3-yl, group are useful in the treatment of cerebral disorders.
    Type: Grant
    Filed: February 20, 1995
    Date of Patent: August 27, 1996
    Assignee: SYNTHELABO
    Inventors: Jonathan Frost, Pascal George, Patrick Pasau, R egine Bartsch, Corinne Rousselle, Paul H. Williams, Jean C. Muller
  • Patent number: 5543421
    Abstract: Ifenprodil and its enantiomers are disclosed for the preparation of medicines useful for the treatment of peripheral neuropathies and chronic neurodegenerative diseases of the central nervous system.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: August 6, 1996
    Assignee: Synthelabo
    Inventors: J esus Benavides, Badia Ferzaz, Pascal George, Bernard Scatton
  • Patent number: D512297
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: December 6, 2005
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D512898
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: December 20, 2005
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D520848
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: May 16, 2006
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D526556
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: August 15, 2006
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D532421
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: November 21, 2006
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D484883
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: January 6, 2004
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Jonathan P. Payne, Arnon Alexander, Michael T. Flanagan