Patents by Inventor Pascal Georges

Pascal Georges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210024507
    Abstract: Compounds of formula (I): and related aspects.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Emma Blackham, Geraint Jones, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • Publication number: 20210002269
    Abstract: Compounds of formula (I): (I) and related aspects.
    Type: Application
    Filed: November 11, 2018
    Publication date: January 7, 2021
    Inventors: Abdul QUDDUS, Andrew Novak, David COUSIN, Elli CHATZOPOULOU, Emma BLACKHAM, Geraint JONES, Jennifer Thomas, Joesph WRIGGLESWORTH, Lorna DUFFY, Louise BIRCH, Pascal GEORGE, Saleh AHMED
  • Patent number: 9726178
    Abstract: A coolant pump includes an impeller pump wheel, a pump housing defining an outlet volute, and an outlet valve arrangement. The pump housing comprises an outlet volute housing which defines a first outlet channel comprising a valve opening. The valve opening is defined by a valve seat which defines a valve seat plane and a symmetry plane. The symmetry plane is arranged in the middle of and rectangular to the valve seat plane. The outlet valve arrangement is in the first outlet channel and comprises a valve flap which opens/closes the valve opening. The valve flap comprises a flap seat corresponding to the valve seat. The valve flap rotates around a pivot axis parallel to the symmetry plane and having an eccentricity from the symmetry plane which is between 1/20 and 1/1 of a distance of the pivot axis to the valve seat plane when the valve flap is open.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: August 8, 2017
    Assignee: PIERBURG PUMP TECHNOLOGY GMBH
    Inventors: Arnaud Fournier, Pascal Georges, Gilles Simon
  • Patent number: 9689393
    Abstract: A coolant pump includes an outlet volute comprising a pivot axis, an impeller pump, a housing, and an outlet valve arrangement. The housing comprises an outlet volute housing defining the outlet volute and comprises a volute housing wall comprising a recess, and a first outlet channel comprising a valve opening. The outlet valve arrangement is disposed in the first outlet channel and comprises a valve body which opens or closes the valve opening. The valve body comprises a circle segment body comprising a proximal surface and a maximum outside radius. The circle segment body is rotated around the pivot axis. The proximal surface is distant from the pivot axis by an offset distance which is at least ¼ of the maximum outside radius. The recess houses the circle segment body in the closed valve position. A lateral distance of the pivot axis to the volute housing wall is approximately equal to the offset distance.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: June 27, 2017
    Assignee: PIERBURG PUMP TECHNOLOGY GMBH
    Inventors: Arnaud Fournier, Gilles Simon, Pascal Georges, Laurent Finidori
  • Publication number: 20150016966
    Abstract: A coolant pump includes an outlet volute comprising a pivot axis, an impeller pump, a housing, and an outlet valve arrangement. The housing comprises an outlet volute housing defining the outlet volute and comprises a volute housing wall comprising a recess, and a first outlet channel comprising a valve opening. The outlet valve arrangement is disposed in the first outlet channel and comprises a valve body which opens or closes the valve opening. The valve body comprises a circle segment body comprising a proximal surface and a maximum outside radius. The circle segment body is rotated around the pivot axis. The proximal surface is distant from the pivot axis by an offset distance which is at least ¼ of the maximum outside radius. The recess houses the circle segment body in the closed valve position. A lateral distance of the pivot axis to the volute housing wall is approximately equal to the offset distance.
    Type: Application
    Filed: February 14, 2012
    Publication date: January 15, 2015
    Applicant: Pierburg Pump Technology GmbH
    Inventors: Arnaud Fournier, Gilles Simon, Pascal Georges, Laurent Finidori
  • Publication number: 20150016967
    Abstract: A coolant pump includes an impeller pump wheel, a pump housing defining an outlet volute, and an outlet valve arrangement. The pump housing comprises an outlet volute housing which defines a first outlet channel comprising a valve opening. The valve opening is defined by a valve seat which defines a valve seat plane and a symmetry plane. The symmetry plane is arranged in the middle of and rectangular to the valve seat plane. The outlet valve arrangement is in the first outlet channel and comprises a valve flap which opens/closes the valve opening. The valve flap comprises a flap seat corresponding to the valve seat. The valve flap rotates around a pivot axis parallel to the symmetry plane and having an eccentricity from the symmetry plane which is between 1/20 and 1/1 of a distance of the pivot axis to the valve seat plane when the valve flap is open.
    Type: Application
    Filed: May 31, 2012
    Publication date: January 15, 2015
    Applicant: PIERBURG PUMP TECHNOLOGY GMBH
    Inventors: Arnaud Fournier, Pascal Georges, Gilles Simon
  • Patent number: 8846676
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 30, 2014
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Mathieu Barrague, Philippe Burnier, Cecile Enguehard-Gueiffier, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frederic Peuch, Roy Vaz, Qiuxia Zhao
  • Publication number: 20130190314
    Abstract: The invention relates to derivatives of 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine and 6-cycloamino-2-furanyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine with general formula (I). The invention also relates to a method for the preparation and therapeutic application thereof, in the treatment or prevention of illnesses involving casein kinase 1 epsilon and/or casein kinase 1 delta.
    Type: Application
    Filed: December 17, 2009
    Publication date: July 25, 2013
    Inventors: Yulin Chiang, Cecile Enguehard-Gueiffier, Pascal George, Alaim Gueiffier, Frederic Puech, Mireille Sevrin, Qiuxia Zhao
  • Patent number: 8354405
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 15, 2013
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Matthieu Barrague, Philippe Burnier, Cécile Enguehard, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frédéric Puech, Roy Vaz, Qiuxia Zhao
  • Publication number: 20130012516
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: SANOFI
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PUACH, Roy VAZ, Qiuxia ZHAO
  • Publication number: 20100179154
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 15, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD-GUEIFFIER, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PEUCH, Roy VAZ, Qiuxia ZHAO
  • Publication number: 20090148528
    Abstract: A material controllingly releases by evaporation a liquid active substance and comprises a polymer material matrix impregnated with a liquid composition. The liquid composition contains a mixture of the active substance and a solute which reduces the active substance evaporation kinetics by decreasing a vapor pressure. A method for producing the material and an accessory comprising an element made therefrom are also described.
    Type: Application
    Filed: September 4, 2006
    Publication date: June 11, 2009
    Inventor: Serge Pascal Georges
  • Publication number: 20090088470
    Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.
    Type: Application
    Filed: December 4, 2008
    Publication date: April 2, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio ALMARIO-GARCIA, Pascal George, Christian Hoornaert, Adrien Tak Li, Frederic Puech
  • Patent number: 7507743
    Abstract: The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 24, 2009
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Pascal George, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7476756
    Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: January 13, 2009
    Assignee: Sanofi-Aventis
    Inventors: Antonio Almario-Garcia, Pascal George, Christian Hoornaert, Adrien Tak Li, Frederic Puech
  • Publication number: 20080103197
    Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 1, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio ALMARIO-GARCIA, Pascal GEORGE, Christian HOORNAERT, Adrien Tak LI, Frederic PUECH
  • Publication number: 20080081819
    Abstract: The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 3, 2008
    Applicants: SANOFI-AVENTIS, MITSUBISHI PHARMA CORPORATION
    Inventors: Pascal GEORGE, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • Patent number: 7294632
    Abstract: The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: November 13, 2007
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Pascal George, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: D526556
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: August 15, 2006
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar
  • Patent number: D532421
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: November 21, 2006
    Assignee: Onity, Inc.
    Inventors: Pascal Georges Metivier, Arnon Alexander, Jonathan P. Payne, John D. Coleman, Peter D. Byar