Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumor growth.

Abstract: A device is provided including a first sleeve for receiving a graphic medium, the first sleeve having a first window allowing the graphic medium to be viewed, and a second sleeve allowing an electronic appliance with a built-in electronic display to be received, the second sleeve including a second window allowing all of part of the electronic display to be viewed, the first and second sleeves being connected to each other. The first window allows the graphic medium to be viewed, which allows the personalization of the device.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Abstract: The present invention relates to amino acid sequences that are directed against G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

Abstract: A bushing for a variable set blade includes a cylindrical part configured to receive the blade, the root of the blade being able to rotate in the cylindrical part, and a base including: a first side able to be put in contact with a first edge of a circumferential groove of the ring, and/or a second side able to be put in contact with a second edge of the circumferential groove of the ring. At least one of the first side or second side of the base includes at least one bevel through which the first side or the second side is able to be put in contact with one of the first edge or second edge of the circumferential groove so as to block the bushing in rotation. The invention finds a particularly interesting application in the field of aircraft.

Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Abstract: The invention relates to a rear section (11) of an aircraft nacelle, that comprises two halves (13a, 13b) defining: a central portion (C) for receiving a turbojet engine (7), a cool-air annular passage (31) provided around said central portion (C), and at least one six-hour cavity (15) provided under said central portion (C). The rear section is characterized in that it comprises at least one duct (29a, 29b) for the fluidic communication between said annular passage (31) and said six-hour cavity (15) for maintaining the temperature inside the six-hour cavity (15) within a relatively low range.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: The present invention relates to a jet engine nacelle comprising a forward air inlet section, a mid-section intended to surround a jet engine fan, and an aft section equipped with at least one thrust reversal system comprising, on the one hand, means for deflecting at least part of an air flow of the jet engine and, on the other hand, at least one cowl (12) mounted translatably along at least one guide rail (15) in a direction substantially parallel to a longitudinal axis of the nacelle, said movable cowl being able to switch alternately from a closed position, in which it provides the nacelle with aerodynamic continuity and covers the deflection means, to an open position in which it opens a passage in the nacelle and uncovers said deflection means, the nacelle being characterized in that the aft section is equipped with at least one stud (18) mounted such that it can move over a fixed structure of the aft section in the region of the guide rail between a retracted position, in which said stud is withdrawn f

Abstract: A bushing for a variable set blade includes a cylindrical part configured to receive the blade, the root of the blade being able to rotate in the cylindrical part, and a base including: a first side able to be put in contact with a first edge of a circumferential groove of the ring, and/or a second side able to be put in contact with a second edge of the circumferential groove of the ring. At least one of the first side or second side of the base includes at least one bevel through which the first side or the second side is able to be put in contact with one of the first edge or second edge of the circumferential groove so as to block the bushing in rotation. The invention finds a particularly interesting application in the field of aircraft.

Abstract: The invention relates to a rear section (11) of an aircraft nacelle, that comprises two halves (13a, 13b) defining: a central portion (C) for receiving a turbojet engine (7), a cool-air annular passage (31) provided around said central portion (C), and at least one six-hour cavity (15) provided under said central portion (C). The rear section is characterised in that it comprises at least one duct (29a, 29b) for the fluidic communication between said annular passage (31) and said six-hour cavity (15) for maintaining the temperature inside the six-hour cavity (15) within a relatively low range.

Abstract: The present invention relates to a jet engine nacelle comprising a forward air inlet section, a mid-section intended to surround a jet engine fan, and an aft section equipped with at least one thrust reversal system comprising, on the one hand, means for deflecting at least part of an air flow of the jet engine and, on the other hand, at least one cowl (12) mounted translatably along at least one guide rail (15) in a direction substantially parallel to a longitudinal axis of the nacelle, said movable cowl being able to switch alternately from a closed position, in which it provides the nacelle with aerodynamic continuity and covers the deflection means, to an open position in which it opens a passage in the nacelle and uncovers said deflection means, the nacelle being characterized in that the aft section is equipped with at least one stud (18) mounted such that it can move over a fixed structure of the aft section in the region of the guide rail between a retracted position, in which said stud is withdrawn f

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Abstract: The present invention relates to amino acid sequences that are directed against vascular endothelial growth factor (VEGF), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization.

Abstract: A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.