Patents by Inventor Pascal Grenier, deceased

Pascal Grenier, deceased has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ultrasound contrast agents and methods of making and using them
    Patent number: 7083778
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: August 1, 2006
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, legal representative, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
  • Ultrasound contrast agents and methods of making and using them
    Patent number: 6989141
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: January 24, 2006
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Gercel, legal representative, Jerome Puginier, Maria-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
  • Stable microbubbles suspensions containing saturated lamellar phospholipids
    Patent number: 6136293
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: October 24, 2000
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, deceased, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
    Patent number: 5578292
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: November 26, 1996
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, deceased, Jerome Puginier, Marie-Bernadette Barrau
  • Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
    Patent number: 5413774
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: May 9, 1995
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, deceased, Jerome Puginier, Marie-Bernadette Barrau