Patents by Inventor Pascal H. Toma

Pascal H. Toma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline form of the compound A-348441
    Patent number: 8124129
    Abstract: There is provided a hemihydrate of (3?,5?,7?,12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: February 28, 2012
    Assignee: Karo Bio AB
    Inventors: Russell Drew Cink, Daozhong Zou, Marvin Robert Leanna, Pascal H. Toma, Michelle Andrée Long
  • Crystalline Form of the Compound A-348441
    Publication number: 20090176754
    Abstract: There is provided a hemihydrate of (3?, 5?, 7?, 12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.
    Type: Application
    Filed: July 12, 2006
    Publication date: July 9, 2009
    Inventors: Russell Drew Cink, Daozhong Zou, Marvin Robert Leanna, Pascal H. Toma, Michelle Andree Long
  • Salt forms of an HIV protease inhibitor
    Publication number: 20020022742
    Abstract: This invention relates generally to salt forms the compound of formula I: 1
    Type: Application
    Filed: July 18, 2001
    Publication date: February 21, 2002
    Inventors: Gregory D. Harris, Stephen R. Anderson, Sridhar Desikan, Paul A. Meenan, Benjamin R. Stone, Pascal H. Toma
  • Crystalline and salt forms of an HIV protease inhibitor
    Publication number: 20020022659
    Abstract: This invention relates generally to crystalline and salt forms of compounds of formula I: 1
    Type: Application
    Filed: July 18, 2001
    Publication date: February 21, 2002
    Inventors: Gregory D. Harris, Stephen R. Anderson, Sridhar Desikan, Paul A. Meenan, Benjamin R. Stone, Pascal H. Toma, Subodh Shrinivas Deshmukh
  • Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
    Patent number: 5585383
    Abstract: By this invention, there is provided a process for producing crystalline 4,7.beta.-dimethyl-4-aza-5.alpha.-cholestan-3-one of structural formula (I) from 4,7.beta.-dimethyl-4-aza-5.alpha.-cholestan-3-one oil. ##STR1## This crystallization process of the present invention comprises crystallization of the oil optionally containing residual solvent with vigorous but controlled agitation. Preferably, this crystallization process is carried out at select and controlled temperatures. Further, 4,7.beta.-dimethyl-4-aza-5.alpha.-cholestan-3-one has been found to exist in at least two novel polymorphic nonsolvated forms, herein referred to as Form I and Form II. Form I can be prepared pure by careful control of the crystallization process.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: December 17, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Andrew L. Forman, Sean R. Holihan, Guy R. Humphrey, David M. Lashen, James A. McCauley, Paul F. McKenzie, Ross A. Miller, Pascal H. Toma