Patents by Inventor Pascal Jean Claude Dott

Pascal Jean Claude Dott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY FOR CANCER TREATMENT
    Publication number: 20260207603
    Abstract: Provided herein are combination therapies comprising a BRAF inhibitor (e.g., a compound of formula (I), or a pharmaceutically acceptable salt thereof) and an EGRF inhibitor (EGRFi), as well as pharmaceutical compositions, methods and uses thereof.
    Type: Application
    Filed: December 14, 2023
    Publication date: July 23, 2026
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jan ECKMANN, Piergiorgio Francesco Tommaso PETTAZZONI, Gabriel SCHNETZLER, Juergen WICHMANN, Pascal Jean Claude DOTT, Serena Maria FANTASIA, Maud GUILLEMOT-PLASS, Dainis KALDRE, Giacomo Marco LARI, Isabelle Georgette Huguette MODOLO-CHELLAT, Joerg Mathias SEDELMEIER, Sebastian TROKOWSKI
  • PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE
    Publication number: 20250313551
    Abstract: The present invention relates to a new process for the preparation of (3R)—N-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale.
    Type: Application
    Filed: June 12, 2025
    Publication date: October 9, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal Jean Claude DOTT, Serena Maria FANTASIA, Maud GUILLEMOT-PLASS, Dainis KALDRE, Giacomo Marco LARI, Isabelle Georgette Huguette MODOLO-CHELLAT, Joerg Mathias SEDELMEIER, Sebastian TROKOWSKI
  • SOLID FORMS
    Publication number: 20250263378
    Abstract: The disclosure is in part directed to crystalline forms of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 27, 2024
    Publication date: August 21, 2025
    Inventors: He Hongyan, Jiang Siyi, Urs Schwitter, Pascal Jean Claude Dott, Ralph Diodone, Nicole Wyttenbach, Olaf Grassmann
  • PROCESS FOR MANUFACTURING MACROCYCLIC PEPTIDES
    Publication number: 20250109166
    Abstract: The invention provides a novel process for manufacturing a compound of formula (I), or a salt thereof, wherein PG1, PG2 and PG3 are amino protective groups. The process according to the invention is particularly suitable for large-scale manufacturing under GMP conditions.
    Type: Application
    Filed: August 13, 2024
    Publication date: April 3, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel Adam, Fritz Bliss, Pascal Jean Claude Dott, Fabienne Roxane Hoffmann-Emery, Ulf Göran Larsson, Kurt Puentener
  • Solid forms
    Patent number: 12134599
    Abstract: The disclosure is in part directed to crystalline forms of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: November 5, 2024
    Assignees: River 3 Renal Corp., Hoffmann-La Roche Inc.
    Inventors: He Hongyan, Jiang Siyi, Urs Schwitter, Pascal Jean Claude Dott, Ralph Diodone, Nicole Wyttenbach, Olaf Grassmann
  • SOLID FORMS
    Publication number: 20240300895
    Abstract: The disclosure is in part directed to crystalline forms of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 11, 2023
    Publication date: September 12, 2024
    Inventors: He Hongyan, Jiang Siyi, Urs Schwitter, Pascal Jean Claude Dott, Ralph Diodone, Nicole Wyttenbach, Olaf Grassmann
  • Solid forms
    Patent number: 11814354
    Abstract: The disclosure is in part directed to crystalline forms of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: November 14, 2023
    Assignee: River 3 Renal Corp.
    Inventors: He Hongyan, Jiang Siyi, Urs Schwitter, Pascal Jean Claude Dott, Ralph Diodone, Nicole Wyttenbach, Olaf Grassmann
  • SOLID FORMS
    Publication number: 20230242485
    Abstract: The disclosure is in part directed to crystalline forms of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 7, 2022
    Publication date: August 3, 2023
    Applicants: River 3 Renal Corp., Hoffmann-La Roche Inc.
    Inventors: He Hongyan, Jiang Siyi, Urs Schwitter, Pascal Jean Claude Dott, Ralph Diodone, Nicole Wyttenbach, Olaf Grassmann