Abstract: Provided herein are methods of treating an autoantibody-mediated disease in a subject, methods of monitoring treatment of an autoantibody-mediated disease in a subject, based on the frequency of B cells in the subject.

Abstract: The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.

Abstract: The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.

Abstract: A method and corresponding tool are described for security policy management in a network comprising a plurality of hosts and at least one configurable policy enforcement point. The method, comprises creating one or more policy templates representing classes of usage control models within the network that are enforceable by configuration of the policy enforcement points; creating one or more policy instances, each based on one of the templates and instantiating the template for identified sets of hosts within the network to which the usage control model is to be applied, deploying the policy instances by generating and providing one or more configuration files for provisioning corresponding policy enforcement points within the network.

Abstract: A method and corresponding tool are described for security policy management in a network comprising a plurality of hosts and at least one configurable policy enforcement point. The method, comprises creating one or more policy templates representing classes of usage control models within the network that are enforceable by configuration of the policy enforcement points; creating one or more policy instances, each based on one of the templates and instantiating the template for identified sets of hosts within the network to which the usage control model is to be applied, deploying the policy instances by generating and providing one or more configuration files for provisioning corresponding policy enforcement points within the network.

Abstract: A network-based service provider architecture. The architecture of the service provider may include a cell based stacked architecture. The network-based service provider architecture may include a plurality of cells hosting a multi-tiered application environment and a common logical network layer. The common logical network layer may provide network connectivity and enforce individual access policy of each cell of the plurality of cells, where each cell is connected to the common logical network layer.