Patents by Inventor Pascal Mieville

Pascal Mieville has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for NMR spectroscopy or MRI measurements using dissolution dynamic nuclear polarization (DNP) with scavenging of free radicals
    Patent number: 8564288
    Abstract: A method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, involves preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation; insertion of the frozen beads into a polarizing magnet; creation of enhanced polarization of nuclei in a magnetic field; heating of the sample to room temperature; transfer of the sample to an MR magnet; and carrying out an MR measurement. In addition, frozen beads of a second kind containing a reducing agent are prepared and inserted into the polarization magnet together with the frozen beads of the first kind. By this method, longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: October 22, 2013
    Assignees: Bruker BioSpin AG, Ecole Polytechniqye Fédérale de Lausanne (EDFL)
    Inventors: Sami Jannin, Pascal Mieville, Geoffrey Bodenhausen
  • Method for NMR spectroscopy or MRI measurements using dissolution dynamic nuclear polarization (DNP) with scavenging of free radicals
    Publication number: 20110175611
    Abstract: A method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, involves preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation; insertion of the frozen beads into a polarizing magnet; creation of enhanced polarization of nuclei in a magnetic field; heating of the sample to room temperature; transfer of the sample to an MR magnet; and carrying out an MR measurement. In addition, frozen beads of a second kind containing a reducing agent are prepared and inserted into the polarization magnet together with the frozen beads of the first kind. By this method, longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.
    Type: Application
    Filed: January 12, 2011
    Publication date: July 21, 2011
    Applicants: Bruker BioSpin AG, Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Sami Jannin, Pascal Mieville, Geoffrey Bodenhausen