Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.

Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.

Abstract: A process for the preparation of expandable polystyrene including the following steps: i°) heating an aqueous suspension including styrene monomer and at least one organic peroxide initiator of formula (I) 1-alkoxy-1-t-alkylperoxycyclohexane in which the alkoxy group contains 1 to 4 carbon atoms, the t-alkyl group contains 4 to 12 carbon atoms, and the cyclohexane ring may optionally be substituted with 1 to 3 alkyl groups each, independently having 1 to 3 carbon atoms, at a temperature ranging from 100° C. to 120° C.), ii°) adding a blowing agent selected from the group of alkanes having from 4 to 6 carbon atoms and mixtures thereof. Also, an expandable polystyrene obtainable according to such a process and to insulation parts and packaging including such an expandable polystyrene.

Abstract: A method for manufacturing polyethylene or an ethylene copolymer, including a step of free radical polymerization or copolymerization of the ethylene at an initiation temperature varying from 150° C. to 200° C., at a pressure varying from 500 to 3000 bar, in the presence of a peroxidic polymerization initiator selected from among the peroxide compounds of formula (I) in which R1 and R8 are, separately, a C2-C6 alkyl group; R2, R3, R6 and R7 are, separately, a C1-C5 alkyl group; and R4 and R5 are, separately, a C1-C6 alkyl group.

Abstract: A process for the preparation of expandable polystyrene including the following steps: i°) heating an aqueous suspension including styrene monomer and at least one organic peroxide initiator of formula (I) 1-alkoxy-1-t-alkylperoxycyclohexane in which the alkoxy group contains 1 to 4 carbon atoms, the t-alkyl group contains 4 to 12 carbon atoms, and the cyclohexane ring may optionally be substituted with 1 to 3 alkyl groups each, independently having 1 to 3 carbon atoms, at a temperature ranging from 100° C. to 120° C., ii°) adding a blowing agent selected from the group of alkanes having from 4 to 6 carbon atoms and mixtures thereof. Also, an expandable polystyrene obtainable according to such a process and to insulation parts and packaging including such an expandable polystyrene.

Abstract: A method for manufacturing polyethylene or an ethylene copolymer, including a step of free radical polymerisation or copolymerisation of the ethylene at an initiation temperature varying from 150° C. to 200° C., at a pressure varying from 500 to 3000 bar, in the presence of a peroxidic polymerisation initiator selected from among the peroxide compounds of formula (I) in which R1 and R8 are, separately, a C2-C6 alkyl group; R2, R3, R6 and R7 are, separately, a C1-C5 alkyl group; and R4 and R5 are, separately, a C1-C6 alkyl group.

Abstract: A process for the preparation of expandable polystyrene including the following steps: i°) heating an aqueous suspension including styrene monomer and at least one organic peroxide initiator of formula (I) 1-alkoxy-1-t-alkylperoxycyclohexane in which the alkoxy group contains 1 to 4 carbon atoms, the t-alkyl group contains 4 to 12 carbon atoms, and the cyclohexane ring may optionally be substituted with 1 to 3 alkyl groups each, independently having 1 to 3 carbon atoms, at a temperature ranging from 100° C. to 120° C.), ii°) adding a blowing agent selected from the group of alkanes having from 4 to 6 carbon atoms and mixtures thereof. Also, an expandable polystyrene obtainable according to such a process and to insulation parts and packaging including such an expandable polystyrene.

Abstract: The present invention relates to a process for the preparation of expandable polystyrene comprising the following steps: io) heating an aqueous suspension comprising styrene monomer and at least one organic peroxide initiator of formula (I) 1-alkoxy-1-t-alkylperoxycyclohexane in which the alkoxy group contains 1 to 4 carbon atoms, the t-alkyl group contains 4 to 12 carbon atoms, and the cyclohexane ring may optionally be substituted with 1 to 3 alkyl groups each, independently having 1 to 3 carbon atoms, at a temperature ranging from 100° C. to 120° C., iio) adding a blowing agent selected from the group consisting of alkanes having from 4 to 6 carbon atoms and mixtures thereof. The invention also relates to an expandable polystyrene obtainable according to such a process and to insulation parts and packaging comprising such an expandable polystyrene.

Abstract: A method of visualizing or graphically printing an automatism application programmed on a programming station with the aid of a graphic automatism languages on a computer terminal. The method includes storing a source program associated with an application program formulated in one of the graphic automatism languages on the terminal, the source program being translated into a single, hierarchical object oriented language (XML); and storing at least one style sheet associated with a graphic language on the computer in order to generate a graphic vector file containing drawing instructions enabling the automatism application to be displayed graphically on the terminal.

Abstract: This invention relates to a programming station for an automation application that will be executed in an automation equipment. The programming station stores at least one file in an internal memory containing a description grammar for automation applications in text format, for at least one of the graphic automation languages (Ladder, SFC, FBD) using a single, hierarchised and object oriented language. It also contains a set of one or several description files, each description file describing part of the automation application and being expressed in this single language. The single, hierarchised and object oriented language is the XML (eXtended Markup Language) language.

Abstract: The invention relates to a method of visualizing or graphically printing an automatism application programmed on a programming station (51) with the aid of graphic automatism languages (LD, SFC, FBD) on a computer terminal (54). Said method comprises a stage in which a source program (50) associated with an application program formulated in one of the graphic automatism languages is stored on the terminal (54), said source program being translated into a single, hierarchical object oriented language (XML); a stage in which at least one style sheet (52) associated with a graphic language is stored on the computer (54) in order to generate a graphic vector file (53) containing drawing instructions enabling the automatism application to be displayed graphically on the terminal (54).

Abstract: This invention relates to a programming station for an automation application that will be executed in an automation equipment. The programming station stores at least one file in an internal memory containing a description grammar for automation applications in text format, for at least one of the graphic automation languages (Ladder, SFC, FBD) using a single, hierarchised and object oriented language. It also contains a set of one or several description files, each description file describing part of the automation application and being expressed in this single language. The single, hierarchised and object oriented language is the XML (eXtended Markup Language) language.

Abstract: This invention relates to a programming station comprising a memory containing description files, each description file describing part of an automation application and being expressed in a single, hierarchised and object oriented language such as the XML language. The programming station uses a compression program that generates a file in the compacted format stored in a memory on the automation equipment, for each description file. The compression program comprises a step to reduce tags contained in a description file by applying a specific stylesheet and a step to execute a compaction algorithm adapted to XML files.

Abstract: The invention relates to a process comprising a stage of polymerization or copolymerization of at least one polymerizable or copolymerizable monomer by a radical mechanism in the presence of a stable free radical and of an initiator of formula: R1—O—O—R2 wherein R1 and R2, which can be identical or different, represent an alkyl, aryl, alkylaryl or aralkyl radical comprising, for example, from 1 to 20 carbon atoms. The process is fast, allows the initiator to act more efficiently and results in polymers or copolymers exhibiting a low yellowing index.

Abstract: The present invention relates to a process for the manufacture of a composition comprising a vinylaromatic polymer and a rubber, wherein the polymerization stage is carried out in the presence of a stable free radical in a polymerization mixture. The presence of the stable free radical in the polymerization mixture makes its possible to increase the melt index and to influence the size of the rubber nodules in the final composition by generally increasing the fraction, by volume, of the rubbery phase and by widening the distribution of the size of these nodules. This is reflected by an improvement both in the melt index and in the impact strength of the final composition, which makes the latter an ideal composition for injection molding.

Abstract: The invention relates to a process for the polymerization or copolymerization of at least one monomer which is polymerizable by the radical route in the presence of a stable free radical from the nitroxide family. The stable free radical is &bgr;-substituted and provides excellent control of polydispersity while ensuring a better rate of polymerization or copolymerization, if they are compared with the stable free radicals used in the prior art.

Abstract: The invention relates to a process for the polymerization or copolymerization of at least one monomer which can be polymerized or copolymerized by the radical route in the presence of a stable free radical and of an iniferter. The presence of the stable free radical greatly modifies the behavior of the iniferter during the polymerization or copolymerization, so that undesirable reactions are much reduced. It is possible, rapidly and with a high yield, to polymerize or copolymerize in the presence of an iniferter in order to result in a polymer or copolymer with a reduced polydispersity and with a monomodal molecular mass distribution.

Abstract: The invention relates to a process for the polymerization or copolymerization of at least one monomer which can be polymerized or copolymerized by the radical route in the presence of a stable free radical and of an iniferter.

Abstract: The present invention relates to the stabilization of a polymer by a stable free radical and in particular to the use of a stable free radical for inhibiting the degradation of a polymer by a mechanism which does not involve oxygen. This use can be carried out when the polymer is in the presence or in the absence of oxygen. The degradation which can be inhibited can be a depolymerization or a crosslinking.

Abstract: A process is provided for the preparation of a bitumen-polymer composition which comprises(a) producing at a temperature of between 100.degree. C. and 230.degree. C., a mixture of(i) a bitumen(ii) a linear block copolymer of styrene and a conjugated diene, the block copolymer being used in a quantity of from 0.5% to 25% by weight of bitumen and having a weight-average molecular weight of between 170,000 and 250,000 and a structure of A-B-A with A denoting a polymer block consisting of a polystyrene block which may be extended on the B side by a random copolymer of styrene and of the conjugated diene and B denoting a polymer block consisting of conjugated diene units, and(iii) a coupling agent containing at least one sulphur-donor compound and used in an amount to provide a quantity of sulphur representing, by weight, 0.1% to 10% of the weight of the linear block copolymer of styrene and conjugated diene; and(b) keeping the mixture thus produced at a temperature of between 100.degree. C. and 230.degree. C.