Patents by Inventor Pascal NICOLE

Pascal NICOLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for the treatment of cancer
    Patent number: 10894042
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: January 19, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DIDEROT—PARIS 7
    Inventors: Alain Couvineau, Valérie Gratio, Pascal Nicole, Thierry Voisin
  • Human monoclonal antibodies against orexin receptor type 1
    Patent number: 10758615
    Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: September 1, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DIDEROT—PARIS 7, INSTITUT REGIONAL DU CANCER DE MONTPELLIER, UNIVERSITE DE MONTPELLIER
    Inventors: Alain Couvineau, Thierry Voisin, Pascal Nicole, Bruno Robert, Pierre Martineau, Myriam Chentouf
  • USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
    Publication number: 20190083508
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 21, 2019
    Inventors: Alain COUVINEAU, Thierry VOISIN, Eric OGIER-DENIS, Nassima MESSAL, Valérie GRATIO, Pascal NICOLE
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER
    Publication number: 20180296549
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 18, 2018
    Inventors: Alain COUVINEAU, Valérie GRATIO, Pascal NICOLE, Thierry VOISIN
  • HUMAN MONOCLONAL ANTIBODIES AGAINST OREXIN RECEPTOR TYPE 1
    Publication number: 20180030135
    Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
    Type: Application
    Filed: January 14, 2016
    Publication date: February 1, 2018
    Inventors: Alain COUVINEAU, Thierry VOISIN, Bruno ROBERT, Pascal NICOLE, Myriam CHENTOUF, Pierre MARTINEAU
  • HUMAN MONOCLONAL ANTIBODIES AGAINST OREXIN RECEPTOR TYPE 1
    Publication number: 20180002421
    Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
    Type: Application
    Filed: January 14, 2016
    Publication date: January 4, 2018
    Inventors: Alain COUVINEAU, Thierry VOISIN, Pascal NICOLE, Bruno ROBERT, Pierre MARTINEAU, Myriam CHENTOUF