Patents by Inventor Pascal Rajagopalan

Pascal Rajagopalan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11650192
    Abstract: A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 16, 2023
    Inventors: Pascal Rajagopalan, Julien Gross, Pierre Caruso
  • Patent number: 11286179
    Abstract: A flow-through fluid purification device (1), which comprises a container (5) arranged such that fluid to be purified can flow-through a volume (8) of the container (5) from an inlet (3) to an outlet (7), a receptacle (10) for accommodating a radiation source in the form of a lamp (13), wherein the receptacle (10) has an interface wall (11) permeable for radiation with a wavelength in the UV-range, preferably between 150 nm and 200 nm, more preferably of 172±8 nm, and arranged to let radiation pass into the volume (8) of the container (5), a plurality of baffle plates (9) located in the volume (8) of the container (5) with an inter-baffle distance (D) in the flow direction from the inlet (3) to the outlet (7), wherein the baffle plates (9) are arranged to force the fluid flowing from the inlet (3) to the outlet (7) to flow substantially along the interface wall (11) and through gaps (G) between the interface wall (11) and the baffle plates (9) defining the shortest distance between the interface wall (11) and
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 29, 2022
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano
  • Patent number: 10768132
    Abstract: The present patent application relates to a device (1) for measuring the conductivity of a liquid, which comprises a measuring chamber for containing a sampling volume to be irradiated with UV rays formed in a hydraulic body (4) which comprises an inlet channel for feeding the measuring chamber with liquid to be measured and an outlet channel for removing the measured liquid from the measuring chamber, the inlet channel and the outlet channel emerging on either side beyond a surface exposed to the UV rays, such that only the sampling volume contained in the measuring chamber is irradiated. The present patent application is also directed towards a use of such a device and to a purification system comprising such a device.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 8, 2020
    Assignee: Merck Patent GmbH
    Inventors: Pascal Rajagopalan, Yves Gaignet, Celine Le Ninivin Glipa
  • Publication number: 20200062615
    Abstract: A flow-through fluid purification device (1), which comprises a container (5) arranged such that fluid to be purified can flow-through a volume (8) of the container (5) from an inlet (3) to an outlet (7), a receptacle (10) for accommodating a radiation source in the form of a lamp (13), wherein the receptacle (10) has an interface wall (11) permeable for radiation with a wavelength in the UV-range, preferably between 150 nm and 200 nm, more preferably of 172±8 nm, and arranged to let radiation pass into the volume (8) of the container (5), a plurality of baffle plates (9) located in the volume (8) of the container (5) with an inter-baffle distance (D) in the flow direction from the inlet (3) to the outlet (7), wherein the baffle plates (9) are arranged to force the fluid flowing from the inlet (3) to the outlet (7) to flow substantially along the interface wall (11) and through gaps (G) between the interface wall (11) and the baffle plates (9) defining the shortest distance between the interface wall (11) and
    Type: Application
    Filed: February 20, 2017
    Publication date: February 27, 2020
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano
  • Publication number: 20200003747
    Abstract: A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.
    Type: Application
    Filed: February 20, 2018
    Publication date: January 2, 2020
    Inventors: Pascal Rajagopalan, Julien Gross, Pierre Caruso
  • Patent number: 9695062
    Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: July 4, 2017
    Assignee: Merck Patent GmbH
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
  • Patent number: 9617171
    Abstract: A biocidal purification reactor, including a main cylinder tube (1A;1B), at least one end cap (2A,2B,2C) closing at least one axial end opening of the main cylinder tube (1A;1B), at least two ports (3A,3B) communicating with the interior volume (4) of the main cylinder tube (1A;1B) in the vicinity of the respective axial ends of the cylinder tube (1A;1B), and at least one of said end caps (2A) or said main cylinder tube (1B) including a UV-light source (7A;7B).
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: April 11, 2017
    Assignee: Merck Patent GmbH
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet
  • Publication number: 20170029292
    Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).
    Type: Application
    Filed: September 20, 2016
    Publication date: February 2, 2017
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
  • Patent number: 9475708
    Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: October 25, 2016
    Assignee: Merck Patent GmbH
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
  • Publication number: 20160107904
    Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).
    Type: Application
    Filed: April 24, 2014
    Publication date: April 21, 2016
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
  • Publication number: 20160083272
    Abstract: A biocidal purification reactor, including a main cylinder tube (1A;1B), at least one end cap (2A,2B,2C) closing at least one axial end opening of the main cylinder tube (1A;1B), at least two ports (3A,3B) communicating with the interior volume (4) of the main cylinder tube (1A;1B) in the vicinity of the respective axial ends of the cylinder tube (1A;1B), and at least one of said end caps (2A) or said main cylinder tube (1B) including a UV-light source (7A;7B).
    Type: Application
    Filed: April 24, 2014
    Publication date: March 24, 2016
    Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet
  • Publication number: 20160084784
    Abstract: The present patent application relates to a device (1) for measuring the conductivity of a liquid, which comprises a measuring chamber for containing a sampling volume to be irradiated with UV rays formed in a hydraulic body (4) which comprises an inlet channel for feeding the measuring chamber with liquid to be measured and an outlet channel for removing the measured liquid from the measuring chamber, the inlet channel and the outlet channel emerging on either side beyond a surface exposed to the UV rays, such that only the sampling volume contained in the measuring chamber is irradiated. The present patent application is also directed towards a use of such a device and to a purification system comprising such a device.
    Type: Application
    Filed: April 14, 2014
    Publication date: March 24, 2016
    Inventors: Pascal Rajagopalan, Yves Gaignet, Celine Le Ninivin Glipa
  • Patent number: 8793076
    Abstract: Disclosed is a method for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series a filter, an oxidizing device and a polishing device, and further including a resistivity measuring device for measuring the resitivity of water to determine the purity thereof. Only one resistivity measuring cell is used, and the outlet points of the filter and the oxidizing device are connected to the resistivity measuring cell by pipes provided with an analysis valve and/or check valves selectively enabling circulation of the liquid within them.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: July 29, 2014
    Assignee: EMD Millipore Corporation
    Inventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin Glipa, Aristotelis Dimitrakopoulos
  • Patent number: 8618820
    Abstract: This is a method for analyzing the purity of water at the outlet from a purification device. It includes the following steps: a) sending the liquid at the outlet from the filter means to a resistivity measuring cell to determine its resistivity ?UPW; b) establishing a reference mode by exposing a portion of the liquid to said oxidation means (2) during a given number of significantly different time periods; c) determining by regression the resistivity at infinity ??REF of said liquid in this reference mode; d) establishing an analysis mode by causing said liquid to be analyzed to pass through the resistivity measuring cell; e) determining the resistivity at infinity ?? of said liquid in this analysis mode by successive iterations; and f) calculating the quantity of organic compounds contained in the purified liquid from this resistivity at infinity ?? and at least the values ?UPW and ??REF.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: December 31, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
  • Publication number: 20130269425
    Abstract: This is a device for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series filter means (1), oxidation means (2) and polishing means (3), further including means for measuring the resistivity of water to determine the purity thereof, characterized in that it includes only one resistivity measuring cell (4) and in that the outlet points of said filter means (1) and said oxidation means (2) are connected to said resistivity measuring cell (4) by pipes provided with an analysis valve (6) and/or check valves (5) selectively enabling circulation of said liquid within them.
    Type: Application
    Filed: June 11, 2013
    Publication date: October 17, 2013
    Inventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
  • Patent number: 8483973
    Abstract: Disclosed is a device for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series a filter, an oxidizing device and a polishing device, and further including a resistivity measuring device for measuring the resistivity of water to determine the purity thereof. Only one resistivity measuring cell is used, and the outlet points of the filter and the oxidizing device are connected to the resistivity measuring cell by pipes provided with an analysis valve and/or check valves selectively enabling circulation of the liquid within them.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: July 9, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
  • Patent number: 8377694
    Abstract: A method for the calibration of a device for measuring the total organic carbon content (TOC) of an aqueous solution by measuring resistivity. The method includes the following steps, in the presence of a reference TOC analyzer: (a) producing a calibration point by a measurement carried out on ultrapure water by the device and the analyzer; (b) producing a plurality of calibration points, each calibration point corresponding to a measurement of the resistivity of a solution having a given content of photo-oxidizable compound, by the device and the analyzer, in order to establish a correlation between the values measured by the device and the analyzer; and (c) calibrating the device by at least one algorithm, based on the measurements carried out in the previous step.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: February 19, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Pascal Rajagopalan, Celine Le Ninivin-Glipa, Antony Vanheghe
  • Patent number: 8179141
    Abstract: The invention relates to a method of measuring the conductivity of a pure or ultrapure liquid, notably water, using electrodes, characterized in that it consists in determining the conductivity by modeling the liquid in the form of an equivalent electrical circuit diagram comprising a resistor R, a capacitor Cp in parallel with the resistor R, and a series capacitor Cs. It also relates to a device for implementing this method and a purification system incorporating such a device.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: May 15, 2012
    Assignee: EMD Millipore Corporation
    Inventors: Pascal Rajagopalan, Aristotelis Dimitrakopoulos, Celine Le Ninivin, Antony Vanheghe
  • Publication number: 20120062243
    Abstract: The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. It also relates to the conductivity measuring device obtained by that method and to a device for measuring the Total Organic Carbon quantity implementing that conductivity measuring device.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 15, 2012
    Applicant: MILLIPORE CORPORATION
    Inventors: Aristotelis Dimitrakopoulos, Pascal Rajagopalan, Celine Le Ninivin, Yves Gaignet, Chester L. Bejtlich, III
  • Publication number: 20120061346
    Abstract: The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. It also relates to the conductivity measuring device obtained by that method and to a device for measuring the Total Organic Carbon quantity implementing that conductivity measuring device.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 15, 2012
    Applicant: MILLIPORE CORPORATION
    Inventors: Aristotelis Dimitrakopoulos, Pascal Rajagopalan, Celine Le Ninivin, Yves Gaignet, Chester L. Bejtlich, III