Patents by Inventor Pascal Rajagopalan
Pascal Rajagopalan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11650192Abstract: A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.Type: GrantFiled: February 20, 2018Date of Patent: May 16, 2023Inventors: Pascal Rajagopalan, Julien Gross, Pierre Caruso
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Patent number: 11286179Abstract: A flow-through fluid purification device (1), which comprises a container (5) arranged such that fluid to be purified can flow-through a volume (8) of the container (5) from an inlet (3) to an outlet (7), a receptacle (10) for accommodating a radiation source in the form of a lamp (13), wherein the receptacle (10) has an interface wall (11) permeable for radiation with a wavelength in the UV-range, preferably between 150 nm and 200 nm, more preferably of 172±8 nm, and arranged to let radiation pass into the volume (8) of the container (5), a plurality of baffle plates (9) located in the volume (8) of the container (5) with an inter-baffle distance (D) in the flow direction from the inlet (3) to the outlet (7), wherein the baffle plates (9) are arranged to force the fluid flowing from the inlet (3) to the outlet (7) to flow substantially along the interface wall (11) and through gaps (G) between the interface wall (11) and the baffle plates (9) defining the shortest distance between the interface wall (11) andType: GrantFiled: February 20, 2018Date of Patent: March 29, 2022Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano
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Patent number: 10768132Abstract: The present patent application relates to a device (1) for measuring the conductivity of a liquid, which comprises a measuring chamber for containing a sampling volume to be irradiated with UV rays formed in a hydraulic body (4) which comprises an inlet channel for feeding the measuring chamber with liquid to be measured and an outlet channel for removing the measured liquid from the measuring chamber, the inlet channel and the outlet channel emerging on either side beyond a surface exposed to the UV rays, such that only the sampling volume contained in the measuring chamber is irradiated. The present patent application is also directed towards a use of such a device and to a purification system comprising such a device.Type: GrantFiled: April 14, 2014Date of Patent: September 8, 2020Assignee: Merck Patent GmbHInventors: Pascal Rajagopalan, Yves Gaignet, Celine Le Ninivin Glipa
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Publication number: 20200062615Abstract: A flow-through fluid purification device (1), which comprises a container (5) arranged such that fluid to be purified can flow-through a volume (8) of the container (5) from an inlet (3) to an outlet (7), a receptacle (10) for accommodating a radiation source in the form of a lamp (13), wherein the receptacle (10) has an interface wall (11) permeable for radiation with a wavelength in the UV-range, preferably between 150 nm and 200 nm, more preferably of 172±8 nm, and arranged to let radiation pass into the volume (8) of the container (5), a plurality of baffle plates (9) located in the volume (8) of the container (5) with an inter-baffle distance (D) in the flow direction from the inlet (3) to the outlet (7), wherein the baffle plates (9) are arranged to force the fluid flowing from the inlet (3) to the outlet (7) to flow substantially along the interface wall (11) and through gaps (G) between the interface wall (11) and the baffle plates (9) defining the shortest distance between the interface wall (11) andType: ApplicationFiled: February 20, 2017Publication date: February 27, 2020Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano
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Publication number: 20200003747Abstract: A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.Type: ApplicationFiled: February 20, 2018Publication date: January 2, 2020Inventors: Pascal Rajagopalan, Julien Gross, Pierre Caruso
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Patent number: 9695062Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).Type: GrantFiled: September 20, 2016Date of Patent: July 4, 2017Assignee: Merck Patent GmbHInventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
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Patent number: 9617171Abstract: A biocidal purification reactor, including a main cylinder tube (1A;1B), at least one end cap (2A,2B,2C) closing at least one axial end opening of the main cylinder tube (1A;1B), at least two ports (3A,3B) communicating with the interior volume (4) of the main cylinder tube (1A;1B) in the vicinity of the respective axial ends of the cylinder tube (1A;1B), and at least one of said end caps (2A) or said main cylinder tube (1B) including a UV-light source (7A;7B).Type: GrantFiled: April 24, 2014Date of Patent: April 11, 2017Assignee: Merck Patent GmbHInventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet
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Publication number: 20170029292Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).Type: ApplicationFiled: September 20, 2016Publication date: February 2, 2017Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
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Patent number: 9475708Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).Type: GrantFiled: April 24, 2014Date of Patent: October 25, 2016Assignee: Merck Patent GmbHInventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
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Publication number: 20160107904Abstract: A biocidal fluid purification cap (2) for a fluid container (1), preferably one storing purified water for use in laboratory environments and especially purified water for cell culture and water for molecular biology. The purification cap (2) includes a cap body (3) including an engagement feature (20) for removably attaching the cap body (3) to a mating engagement feature on a spout of the fluid container (1) to hermetically close a spout opening, at least one LED (7a) adapted to emit light in the UV-C range, electronic circuitry (15) for driving the LED(s) (7a), and a power supply for the electronic circuitry (15). The LED(s) (7a) is/are arranged in said cap body (3) so as to be separated from the environment by an UV-transparent window (6) provided in the cap body (3) such that light emitted from said LED(s) (7a) enters the opening of the spout when the cap (2) is attached to the spout of the container (1).Type: ApplicationFiled: April 24, 2014Publication date: April 21, 2016Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet, Julien Bole
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Publication number: 20160083272Abstract: A biocidal purification reactor, including a main cylinder tube (1A;1B), at least one end cap (2A,2B,2C) closing at least one axial end opening of the main cylinder tube (1A;1B), at least two ports (3A,3B) communicating with the interior volume (4) of the main cylinder tube (1A;1B) in the vicinity of the respective axial ends of the cylinder tube (1A;1B), and at least one of said end caps (2A) or said main cylinder tube (1B) including a UV-light source (7A;7B).Type: ApplicationFiled: April 24, 2014Publication date: March 24, 2016Inventors: Pascal Rajagopalan, Julien Gross, Ichiro Kano, Yves Gaignet
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Publication number: 20160084784Abstract: The present patent application relates to a device (1) for measuring the conductivity of a liquid, which comprises a measuring chamber for containing a sampling volume to be irradiated with UV rays formed in a hydraulic body (4) which comprises an inlet channel for feeding the measuring chamber with liquid to be measured and an outlet channel for removing the measured liquid from the measuring chamber, the inlet channel and the outlet channel emerging on either side beyond a surface exposed to the UV rays, such that only the sampling volume contained in the measuring chamber is irradiated. The present patent application is also directed towards a use of such a device and to a purification system comprising such a device.Type: ApplicationFiled: April 14, 2014Publication date: March 24, 2016Inventors: Pascal Rajagopalan, Yves Gaignet, Celine Le Ninivin Glipa
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Patent number: 8793076Abstract: Disclosed is a method for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series a filter, an oxidizing device and a polishing device, and further including a resistivity measuring device for measuring the resitivity of water to determine the purity thereof. Only one resistivity measuring cell is used, and the outlet points of the filter and the oxidizing device are connected to the resistivity measuring cell by pipes provided with an analysis valve and/or check valves selectively enabling circulation of the liquid within them.Type: GrantFiled: June 11, 2013Date of Patent: July 29, 2014Assignee: EMD Millipore CorporationInventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin Glipa, Aristotelis Dimitrakopoulos
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Patent number: 8618820Abstract: This is a method for analyzing the purity of water at the outlet from a purification device. It includes the following steps: a) sending the liquid at the outlet from the filter means to a resistivity measuring cell to determine its resistivity ?UPW; b) establishing a reference mode by exposing a portion of the liquid to said oxidation means (2) during a given number of significantly different time periods; c) determining by regression the resistivity at infinity ??REF of said liquid in this reference mode; d) establishing an analysis mode by causing said liquid to be analyzed to pass through the resistivity measuring cell; e) determining the resistivity at infinity ?? of said liquid in this analysis mode by successive iterations; and f) calculating the quantity of organic compounds contained in the purified liquid from this resistivity at infinity ?? and at least the values ?UPW and ??REF.Type: GrantFiled: June 4, 2009Date of Patent: December 31, 2013Assignee: EMD Millipore CorporationInventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
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Publication number: 20130269425Abstract: This is a device for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series filter means (1), oxidation means (2) and polishing means (3), further including means for measuring the resistivity of water to determine the purity thereof, characterized in that it includes only one resistivity measuring cell (4) and in that the outlet points of said filter means (1) and said oxidation means (2) are connected to said resistivity measuring cell (4) by pipes provided with an analysis valve (6) and/or check valves (5) selectively enabling circulation of said liquid within them.Type: ApplicationFiled: June 11, 2013Publication date: October 17, 2013Inventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
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Patent number: 8483973Abstract: Disclosed is a device for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series a filter, an oxidizing device and a polishing device, and further including a resistivity measuring device for measuring the resistivity of water to determine the purity thereof. Only one resistivity measuring cell is used, and the outlet points of the filter and the oxidizing device are connected to the resistivity measuring cell by pipes provided with an analysis valve and/or check valves selectively enabling circulation of the liquid within them.Type: GrantFiled: June 2, 2009Date of Patent: July 9, 2013Assignee: EMD Millipore CorporationInventors: Pascal Rajagopalan, Antony Vanheghe, Celine Le Ninivin, Aristotelis Dimitrakopoulos
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Patent number: 8377694Abstract: A method for the calibration of a device for measuring the total organic carbon content (TOC) of an aqueous solution by measuring resistivity. The method includes the following steps, in the presence of a reference TOC analyzer: (a) producing a calibration point by a measurement carried out on ultrapure water by the device and the analyzer; (b) producing a plurality of calibration points, each calibration point corresponding to a measurement of the resistivity of a solution having a given content of photo-oxidizable compound, by the device and the analyzer, in order to establish a correlation between the values measured by the device and the analyzer; and (c) calibrating the device by at least one algorithm, based on the measurements carried out in the previous step.Type: GrantFiled: October 4, 2010Date of Patent: February 19, 2013Assignee: EMD Millipore CorporationInventors: Pascal Rajagopalan, Celine Le Ninivin-Glipa, Antony Vanheghe
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Patent number: 8179141Abstract: The invention relates to a method of measuring the conductivity of a pure or ultrapure liquid, notably water, using electrodes, characterized in that it consists in determining the conductivity by modeling the liquid in the form of an equivalent electrical circuit diagram comprising a resistor R, a capacitor Cp in parallel with the resistor R, and a series capacitor Cs. It also relates to a device for implementing this method and a purification system incorporating such a device.Type: GrantFiled: June 1, 2009Date of Patent: May 15, 2012Assignee: EMD Millipore CorporationInventors: Pascal Rajagopalan, Aristotelis Dimitrakopoulos, Celine Le Ninivin, Antony Vanheghe
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Publication number: 20120062243Abstract: The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. It also relates to the conductivity measuring device obtained by that method and to a device for measuring the Total Organic Carbon quantity implementing that conductivity measuring device.Type: ApplicationFiled: November 18, 2011Publication date: March 15, 2012Applicant: MILLIPORE CORPORATIONInventors: Aristotelis Dimitrakopoulos, Pascal Rajagopalan, Celine Le Ninivin, Yves Gaignet, Chester L. Bejtlich, III
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Publication number: 20120061346Abstract: The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. It also relates to the conductivity measuring device obtained by that method and to a device for measuring the Total Organic Carbon quantity implementing that conductivity measuring device.Type: ApplicationFiled: November 18, 2011Publication date: March 15, 2012Applicant: MILLIPORE CORPORATIONInventors: Aristotelis Dimitrakopoulos, Pascal Rajagopalan, Celine Le Ninivin, Yves Gaignet, Chester L. Bejtlich, III