Abstract: A piston ring (10) for forming a seal between a piston (26) and piston housing (28). The piston ring (10) has first and second orthogonal axes (12, 14) and a body portion (18) which is resiliently deformable in the direction of the first axis (12) and is substantially rigid in the direction of the second axis (14).

Abstract: In a fluid-working machine having a high-pressure line and a working chamber, a valve arrangement is arranged to control fluid flow from the high-pressure line to the working chamber. The valve arrangement comprises a main valve having a valve element arranged to provide sealing contact with a valve seat, and an auxiliary valve comprising an electromagnetically-movable valve member for equalising pressure on either side of the main valve by placing the working chamber in direct fluid communication with the high-pressure line. The electromagnetically-movable valve member may comprise a spool valve member or a poppet valve member.

Abstract: The present invention provides a hydraulic pump for use in driving a load with a control modulation system which modulates a primary control signal in order to accommodate variations in secondary changeable parameters which require control at a higher frequency or have a lower latency.

Abstract: A variable transmission comprises a first fluid working machine (1) for connection to a prime mover (2), a second fluid working machine (5) for connection to a mechanical load (6) and a fluid system linking the first and second working machines, the fluid system having a high-pressure side (3) and a low-pressure side (4) each connected to both said first and said second fluid working machines (1, 5), a fluid accumulator (7) on the high-pressure side, a means to admit fluid from the reservoir to the low-pressure side and a pressure control valve to maintain the correct pressure in the low-pressure side, wherein the second fluid working machine (5) includes chambers of variable volume having electronically controllable valves such that each of said chambers has pumping, motoring and idling modes of operation, and the second fluid working machine (5) is operable to both source fluid to and sink fluid from each of said high-pressure side (3) and said low-pressure side (4).

Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

Abstract: A valvetrain control arrangement for an internal combustion engine. A fluid-working machine (1) has working chambers (3) of cyclically varying volume, each connected to a piston actuator (4) which is capable of moving an intake or exhaust valve in the internal combustion engine. The engine crankshaft (2) drives a crankshaft of the fluid-working machine at the same speed as the engine. Each working chamber (3) is linked to a low-pressure manifold (7) by a venting valve (6), the venting valve being normally open but electromagnetically closable by a signal from an electronic sequencing means (8) which operates in timed relationship to the engine crankshaft phase.

Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

Abstract: Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

Abstract: The present invention provides compositions and methods that elicit an immune response against diseased cells. In particular, the present invention provides compositions and methods for the presentation of a peptide related to survivin on antigen-presenting cells. Presentation of the peptide leads to an immune response in a mammal against cells such as tumor cells overexpressing survivin.

Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

Abstract: An external combustion engine (1) comprising pressure vessel means defining a tubular working chamber (3) having spaced apart first and second ends and including first wall means (11), adjacent the first end of the chamber, heated by heating means (10, 11) and second wall means (6), adjacent the second end of the chamber, cooled by cooling means. The engine further has a porous piston or regenerator (7) provided with heat exchanging means (9) and movable within the tubular working chamber (3) between the first and second ends of the chamber so that the working fluid passes through the heat exchanging means. The regenerator (7) has valving means.