Patents by Inventor Pascaline Mary
Pascaline Mary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11724237Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: May 16, 2022Date of Patent: August 15, 2023Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
-
Publication number: 20230045791Abstract: The invention provides monoclonal antibodies and antigen-binding fragments thereof specific for TNFR2, and methods of using the same to treat cancer or autoimmune disorder, including combination therapy with antagonists of the PD-1/PD-L1 immune checkpoint.Type: ApplicationFiled: January 5, 2021Publication date: February 16, 2023Inventors: Shuo Wei, Liang Schweizer, Francisco Adrian, Nicola Arturo Aldo Beltraminelli, Pascaline Mary, Matthieu Delince, Qian Zhang, Jennifer Watkins
-
Publication number: 20220274072Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: ApplicationFiled: May 16, 2022Publication date: September 1, 2022Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
-
Patent number: 11358105Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: January 11, 2021Date of Patent: June 14, 2022Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
-
Publication number: 20210197146Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: ApplicationFiled: January 11, 2021Publication date: July 1, 2021Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
-
Patent number: 10941445Abstract: The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.Type: GrantFiled: March 20, 2018Date of Patent: March 9, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: Tal Raz, Pascaline Mary
-
Patent number: 10919008Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: July 25, 2017Date of Patent: February 16, 2021Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
-
Patent number: 10589274Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: GrantFiled: May 22, 2018Date of Patent: March 17, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Sepehr Kiani, Joshua Blouwolff, Adnan Esmail, Jason Hung, Tony Hung, Adam R. Abate, Scott Powers, Pascaline Mary
-
Patent number: 10569268Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.Type: GrantFiled: November 27, 2017Date of Patent: February 25, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Adam Abate, Sepehr Kiani, Tony Hung, Pascaline Mary, Adnan Moez Esmail
-
Patent number: 10563246Abstract: A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.Type: GrantFiled: October 3, 2011Date of Patent: February 18, 2020Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Marie-Claude Potier, Patrick Tabeling, Luce Dauphinot, Nadege Bois, Fabrice Monti, Pascaline Mary
-
Patent number: 10533212Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.Type: GrantFiled: January 17, 2017Date of Patent: January 14, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Tal Raz, Pascaline Mary
-
Patent number: 10343167Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: GrantFiled: August 30, 2017Date of Patent: July 9, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Adnan Esmail, Tal Raz, John Healy, Tony Hung, Sepehr Kiani, Pascaline Mary
-
Publication number: 20180369818Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: ApplicationFiled: May 22, 2018Publication date: December 27, 2018Inventors: Sepehr KIANI, Joshua BLOUWOLFF, Adnan ESMAIL, Jason HUNG, Tony HUNG, Adam R. ABATE, Scott POWERS, Pascaline MARY
-
Publication number: 20180274029Abstract: The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.Type: ApplicationFiled: March 20, 2018Publication date: September 27, 2018Inventors: Tal RAZ, Pascaline MARY
-
Patent number: 10022721Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: GrantFiled: August 27, 2014Date of Patent: July 17, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Sepehr Kiani, Joshua Blouwolff, Adnan Esmail, Jason Hung, Tony Hung, Adam R. Abate, Scott Powers, Pascaline Mary
-
Patent number: 10012592Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.Type: GrantFiled: October 2, 2017Date of Patent: July 3, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Adam Abate, John Lawrence Emhoff, Tony Hung, Adnan Moez Esmail, Sepehr Kiani, Pascaline Mary
-
Publication number: 20180078933Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.Type: ApplicationFiled: November 27, 2017Publication date: March 22, 2018Inventors: Adam ABATE, Sepehr KIANI, Tony HUNG, Pascaline MARY, Adnan Moez ESMAIL
-
Publication number: 20180045648Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.Type: ApplicationFiled: October 2, 2017Publication date: February 15, 2018Inventors: Adam ABATE, John Lawrence EMHOFF, Tony HUNG, Adnan Moez ESMAIL, Sepehr KIANI, Pascaline MARY
-
Patent number: 9861979Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.Type: GrantFiled: March 28, 2012Date of Patent: January 9, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Adam Abate, Sepehr Kiani, Tony Hung, Pascaline Mary, Adnan Moez Esmail
-
Publication number: 20170361322Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: ApplicationFiled: August 30, 2017Publication date: December 21, 2017Inventors: Adnan ESMAIL, Tal RAZ, John HEALY, Tony HUNG, Sepehr KIANI, Pascaline MARY