Patents by Inventor Pasit Phiasivongsa

Pasit Phiasivongsa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
    Patent number: 8921583
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl, William Dean Fuller, Guy J. Laidig
  • Crystalline tripeptide epoxy ketone protease inhibitors
    Patent number: 8822512
    Abstract: The disclosure features crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: September 2, 2014
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140105921
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 17, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Crystalline peptide epoxyketone immunoproteasome inhibitor
    Patent number: 8697646
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: April 15, 2014
    Assignee: Onyx Therapeutics, Inc.
    Inventor: Pasit Phiasivongsa
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100154
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 10, 2014
    Applicant: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100168
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 10, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Crystalline Tripeptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140024804
    Abstract: The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Application
    Filed: September 24, 2013
    Publication date: January 23, 2014
    Applicant: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl
  • Crystalline tripeptide epoxy ketone protease inhibitors
    Patent number: 8604215
    Abstract: The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. In addition, the compounds provided herein are immunoproteasome inhibitors and are useful, for example, in the treatment of cancer and autoimmune disease.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: December 10, 2013
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl
  • Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein
    Publication number: 20130236536
    Abstract: Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2?-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (DpG and GpD) are provided to target the CpG islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position. Methods for synthesizing these oligonucleotide analogues and for modulating nucleic acid methylation are provided. Also provided are phosphoramidite building blocks for synthesizing the oligonucleotide analogues, methods for synthesizing, formulating and administering these compounds or compositions to treat conditions, such as cancer and hematological disorders.
    Type: Application
    Filed: May 14, 2013
    Publication date: September 12, 2013
    Applicant: Astex Pharmaceuticals, Inc.
    Inventors: Pasit Phiasivongsa, Sanjeev Redkar
  • Oligonucleotide analogues incorporating 5-aza-cytosine therein
    Patent number: 8461123
    Abstract: Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2?-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (DpG and GpD) are provided to target the CpG islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position. Methods for synthesizing these oligonucleotide analogues and for modulating nucleic acid methylation are provided. Also provided are phosphoramidite building blocks for synthesizing the oligonucleotide analogues, methods for synthesizing, formulating and administering these compounds or compositions to treat conditions, such as cancer and hematological disorders.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: June 11, 2013
    Assignee: Astex Pharmaceuticals, Inc.
    Inventors: Pasit Phiasivongsa, Sanjeev Redkar
  • Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same
    Patent number: 8445502
    Abstract: The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: May 21, 2013
    Assignee: Astex Pharmaceuticals, Inc.
    Inventors: David J. Bearss, Rajashree Joshi-Hangal, Xiao-Hui Liu, Pasit Phiasivongsa, Sanjeev G. Redkar, Hariprasad Vankayalapati
  • Crystalline Peptide Epoxyketone Immunoproteasome Inhibitor
    Publication number: 20130065827
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Application
    Filed: April 6, 2011
    Publication date: March 14, 2013
    Inventor: Pasit Phiasivongsa
  • Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
    Patent number: 8367617
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: February 5, 2013
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl, William Dean Fuller, Guy J. Laidig
  • CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20120088903
    Abstract: The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Application
    Filed: March 22, 2010
    Publication date: April 12, 2012
    Inventors: Pasit Phiasivongsa, Louis C. Sehl
  • CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20120077855
    Abstract: The disclosure features crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Application
    Filed: September 20, 2011
    Publication date: March 29, 2012
    Inventors: Pasit Phiasivongsa, Louis C. Sehl
  • QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION
    Publication number: 20110256092
    Abstract: Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
    Type: Application
    Filed: March 14, 2011
    Publication date: October 20, 2011
    Applicant: SUPERGEN, INC.
    Inventors: Pasit Phiasivongsa, Sanjeev G. Redkar, Swarna Gamage, Darby Brooke, William Denny, David J. Bearss, Hariprasad Vankayalapati, Yong Xu, Krzysztof Swierczek
  • Quinoline derivatives for modulating DNA methylation
    Patent number: 7939546
    Abstract: Quinoline derivatives, particularly 4-(4-(4-(quinolin-4-ylamino)benzamido)phenylthio)pyrrolidine-2-carboxylic acid; 3-(4-(4-(quinolin-4-ylamino)benzamido)phenylthio)pyrrolidine; N-(4-(piperidin-4-ylthio)phenyl)-4-(quinolin-4-ylamino)-benzamide; and N-(4-(piperidin-3-ylthio)phenyl)-4-(quinolin-4-ylamino)-benzamide, or a physiologically acceptable salt thereof, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: May 10, 2011
    Assignee: SuperGen, Inc.
    Inventors: Pasit Phiasivongsa, Sanjeev G. Redkar, Swarna Gamage, Darby Brooke, William Denny, David J. Bearss, Hariprasad Vankayalapati, Yong Xu, Krzysztof Swierczek
  • PHARMACEUTICAL FORMULATIONS COMPRISING SALTS OF A PROTEIN KINASE INHIBITOR AND METHODS OF USING SAME
    Publication number: 20110086112
    Abstract: The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
    Type: Application
    Filed: October 18, 2010
    Publication date: April 14, 2011
    Applicant: SUPERGEN, INC.
    Inventors: David J. Bearss, Rajashree Joshi-Hangal, Xiao-Hui Liu, Pasit Phiasivongsa, Sanjeev G. Redkar, Hariprasad Vankayalapati
  • Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same
    Patent number: 7820684
    Abstract: The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: October 26, 2010
    Assignee: SuperGen, Inc.
    Inventors: David J. Bearss, Rajashree Joshi-Hangal, Xiao-Hui Liu, Pasit Phiasivongsa, Sanjeev G. Redkar, Hariprasad Vankayalapati
  • CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20100240903
    Abstract: The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Louis C. Sehl