Abstract: Provided herein is a tube rolling apparatus. The apparatus includes a first arm, a first roller rotatable around a first axis, a second arm, a second roller rotatable around a second axis, and optionally an advancing unit coupled to the first roller and configured to rotate the first roller around the first axis. Related systems and methods are also provided.

Abstract: A time-pressure-filling system for filling liquid drug product into containers is disclosed. The time-pressure-filling system has a storage vessel for storing the liquid drug product and a surge vessel. The surge vessel is configured for single use and is at least partially made of a rigid plastic material. A supply line feeds the liquid drug product from the storage vessel into the surge vessel in a pressurized fashion. A pressure control line is provided for applying a control pressure to the surge vessel, a dispenser is provided for dispensing the liquid drug product into the containers, and a dispensing line connects the surge vessel to the dispenser. A pressure sensor determines pressure in the dispensing line and a valve controls flow of the liquid drug product through the dispensing line. A surge vessel for use in the time-pressure-filling system and a time-pressure-filling method are also disclosed.