Patents by Inventor Pasquale Confalone

Pasquale Confalone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES
    Publication number: 20070027186
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: September 7, 2006
    Publication date: February 1, 2007
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7153960
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides
    Publication number: 20050250946
    Abstract: The present invention is an efficient synthetic route to 2?,3?-dideoxy-2?,3?-didehydro-nucleosides from available precursors with the option of introducing functionality as needed, such as, the 2?,3?-dideoxy and 2?- or 3?-deoxyribo-nucleoside analogs as well as additional derivatives obtained by subsequent functional group manipulations. Briefly, the present invention discloses a method for the preparation of ?-D and ?-L-2?,3?-dideoxy-2?,3?-didehydro-nucleosides starting from appropriately substituted ribonucleosides in two, optionally three steps: Step (1) a haloacylation, such as haloacetylation, and in particular, bromoacetylation; Step (2) a reductive elimination; and optionally, Step (3) a deprotection. The haloacylation of step (1) can form the 2?-acyl-3?-halonucleoside, the 3?-acyl-2?-halonucleoside, or a mixture thereof.
    Type: Application
    Filed: July 18, 2005
    Publication date: November 10, 2005
    Inventors: Pasquale Confalone, Fuqiang Jin
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Publication number: 20050245566
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: June 8, 2005
    Publication date: November 3, 2005
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Patent number: 6919451
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: July 19, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Publication number: 20030181466
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described.
    Type: Application
    Filed: December 3, 2002
    Publication date: September 25, 2003
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone