Patents by Inventor Pati M. Glee

Pati M. Glee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPARTICLE ADJUVANTS FOR SUB-UNIT VACCINES
    Publication number: 20080233181
    Abstract: The present invention relates to nanoparticle vaccine adjuvants comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in order to direct it to a specific site or cell type to optimize a desired immune response. The present invention also relates to encapsulating an antigen or combinations of different antigens within such nanoparticles, with or without a targeting molecule displayed on its surface. The antigens used in this invention are effective to produce an immune response against a variety of pathological conditions.
    Type: Application
    Filed: October 19, 2007
    Publication date: September 25, 2008
    Inventors: Jon O. Nagy, Benfang Lei, Zengshe Kevin Liu, Robert F. Bargatze, John W. Jutila, Jim E. Cutler, Pati M. Glee
  • Nanoparticle vaccines
    Patent number: 7285289
    Abstract: The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in order to direct it to a specific site or cell type to optimize a desired immune response. The present invention also relates to encapsulating an antigen or combinations of different antigens within such nanoparticles, with or without a targeting molecule displayed on its surface. The antigens used in this invention are effective to produce an immune response against a variety of pathological conditions.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: October 23, 2007
    Inventors: Jon O. Nagy, Robert F. Bargatze, John W. Jutila, Jim E. Cutler, Pati M. Glee
  • Nanoparticle vaccines
    Publication number: 20040022840
    Abstract: The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in order to direct it to a specific site or cell type to optimize a desired immune response. The present invention also relates to encapsulating an antigen or combinations of different antigens within such nanoparticles, with or without a targeting molecule displayed on its surface. The antigens used in this invention are effective to produce an immune response against a variety of pathological conditions.
    Type: Application
    Filed: April 14, 2003
    Publication date: February 5, 2004
    Inventors: Jon O. Nagy, Robert F. Bargatze, John W. Jutila, Jim E. Cutler, Pati M. Glee
  • Polyvalent nanoparticles
    Publication number: 20030223938
    Abstract: The present invention relates to nanoparticles comprised of a carrier, particularly polymerized lipids, and ligands displayed on the carrier, wherein the ligands form a polyvalent binding unit that is effective to produce a specific interaction between the nanoparticle and receptors on a target, particularly under physiologically relevant shear conditions.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 4, 2003
    Inventors: John O. Nagy, Robert F. Bargatze, John W. Jutila, Jim E. Cutler, Yongmoon Han, Pati M. Glee, David Pascual
  • Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
    Publication number: 20030072775
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Application
    Filed: February 14, 2002
    Publication date: April 17, 2003
    Applicant: The Research and Development Institute Inc.
    Inventors: Jim E. Cutler, Yongmoon Han, Pati M. Glee, Bruce L. Granger
  • Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
    Patent number: 6391587
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: May 21, 2002
    Inventors: Jim E. Cutler, Pati M. Glee, Bruce L. Granger
  • Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
    Patent number: 6309642
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: October 30, 2001
    Assignee: The Research and Development Institute, Inc.
    Inventors: Jim E. Cutler, Pati M. Glee