Abstract: The invention relates to a method for modelling the behaviour of a circular rolling mill (1) intended for rolling a cylindrical component on the basis of a setpoint, the circular rolling mill comprising at least one tapered roller (3) configured to effect a translational movement in a first direction (Y), and a mandrel (2), configured to effect a translational movement in a second direction (X), the setpoint comprising a setpoint for the rate of increase of an outside diameter of said cylindrical component as a function of said external diameter, and a setpoint for the height of the cylindrical component in the first direction as a function of a thickness of the cylindrical component in the second direction.

Abstract: Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new beta-coronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that BAY-2402234 is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.

Abstract: Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that Vidofludimus is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.

Abstract: A combustion chamber for a turbine engine, in particular for an aircraft turbojet engine or turboprop engine. The combustion chamber includes a radially outer annular shroud, a radially inner annular shroud coaxial with the radially outer shroud, and an end wall connecting the radially outer shroud and the radially inner shroud. The combustion chamber further includes a first annular sealing member coaxial with said radially inner and outer shrouds. The first annular sealing member is radially interposed between the end wall and the radially outer shroud.

Abstract: The provision of air passage holes through a wall of a gas turbomachine combustion chamber. Multi-perforations are virtually positioned and distributed, even in a first safety zone without air passage openings. Multi-perforations with a virtual inlet or outlet in this first security zone are virtually removed. According to certain criteria, at least some of said removed multi-perforations are then virtually reintegrated, and, from then on a perimeter passing through the virtual inlets and outlets of all the multi-perforations present is defined, in the direction of a primary or dilution hole to be installed, a modified safety zone is defined, then, respecting around said hole and with the freedom to reposition it within this limit, the shape of this hole is redefined.

Abstract: An annular combustion chamber of a turbomachine is described. The combustion chamber has an axis of revolution and is delimited by coaxial internal and external annular walls joined upstream by a bottom of chamber substantially transverse to the walls. In some embodiments, the chamber includes at least one annular deflector placed in the chamber and substantially parallel to the bottom of chamber. The bottom of chamber may have openings adapted to be traversed by air for cooling the deflector. In some embodiments, the bottom of chamber and the deflector include mounting openings for mounting an annular row of injection devices for injecting a mixture of air and fuel into the chamber. At least a portion of the air for cooling the deflector is conveyed into the chamber through holes in the injection devices.

Abstract: The inventors surprisingly found that FXR plays a determinant role in the maintenance of viral episome in cells from tissues that are not specialized in bile salt synthesis and transport as the liver or the intestine. In particular, the inventors show that FXR agonist could be suitable for inhibiting the replication of viruses (e.g. BKV and HIV-1) that persist in the cell in an episomal and extrachromosomal form of DNA. Accordingly the present invention relates to a method of reducing persistence and expression of an episomal virus in a subject in need thereof comprising administrating to the subject a therapeutically effective amount of a FXR agonist.

Abstract: The provision of air passage holes through a wall of a gas turbomachine combustion chamber. Multi-perforations are virtually positioned and distributed, even in a first safety zone without air passage openings. Multi-perforations with a virtual inlet or outlet in this first security zone are virtually removed. According to certain criteria, at least some of said removed multi-perforations are then virtually reintegrated, and, from then on a perimeter passing through the virtual inlets and outlets of all the multi-perforations present is defined, in the direction of a primary or dilution hole to be installed, a modified safety zone is defined, then, respecting around said hole and with the freedom to reposition it within this limit, the shape of this hole is redefined.

Abstract: An annular turbine engine combustion chamber wall including air admission orifices to create zones of steep temperature gradient, and cooling orifices to enable the air flowing on the cold side to penetrate to the hot side in order to form a film of cooling air along the annular wall, the annular wall being further includes, in the zones of steep temperature gradient, multi-perforation holes having respective bends of an angle ? greater than 90°, the angle ? being measured between an inlet axis Ae and an outlet axis As of the multi-perforation hole, the outlet axis of the multi-perforation hole being inclined at an angle ?3 relative to the normal N to the annular wall through which the multi-perforation holes with bends are formed, in a “gyration” direction that is at most perpendicular to the axial flow direction D of the combustion gas.

Abstract: An annular combustion chamber with an axis of revolution of a turbine engine delimited by coaxial inner and outer annular walls joined upstream by a substantially transverse bottom of the chamber, the chamber further comprising at least one annular deflector placed in the chamber and substantially parallel to the bottom of the chamber the bottom of the chamber having orifices designed to be passed through by the impact cooling air of the deflector and coming from upstream. The deflector is attached to the inner and outer walls in a sealed manner, and the cooling air of the deflector is discharged from the chamber through exhaust holes formed in the inner and outer walls.

Abstract: An annular combustion chamber of a turbomachine is described. The combustion chamber has an axis of revolution and is delimited by coaxial internal and external annular walls joined upstream by a bottom of chamber substantially transverse to the walls. In some embodiments, the chamber includes at least one annular deflector placed in the chamber and substantially parallel to the bottom of chamber. The bottom of chamber may have openings adapted to be traversed by air for cooling the deflector. In some embodiments, the bottom of chamber and the deflector include mounting openings for mounting an annular row of injection devices for injecting a mixture of air and fuel into the chamber. At least a portion of the air for cooling the deflector is conveyed into the chamber through holes in the injection devices.

Abstract: A combustion chamber for a turbine engine, in particular for an aircraft turbojet engine or turboprop engine. The combustion chamber includes a radially outer annular shroud, a radially inner annular shroud coaxial with the radially outer shroud, and an end wall connecting the radially outer shroud and the radially inner shroud. The combustion chamber further includes a first annular sealing member coaxial with said radially inner and outer shrouds. The first annular sealing member is radially interposed between the end wall and the radially outer shroud.

Abstract: The invention relates to a cosmetic composition comprising at least one extract from the orchid Dendrobium chrysotoxum as an active agent and at least one cosmetically acceptable excipient. The invention relates to the use in a cosmetic composition of an extract from the orchid Dendrobium chrysotoxum as an active agent for preventing or delaying the appearance of the signs of skin ageing or for slowing or attenuating the effects thereof, or else also for promoting cell or tissue longevity. The invention in particular relates to an orchid extract inhibiting the expression and/or the activity of the mitochondrial protein Smac/DIABLO.

Abstract: An annular combustion chamber with an axis of revolution of a turbine engine delimited by coaxial inner and outer annular walls joined upstream by a substantially transverse bottom of the chamber, the chamber further comprising at least one annular deflector placed in the chamber and substantially parallel to the bottom of the chamber the bottom of the chamber having orifices designed to be passed through by the impact cooling air of the deflector and coming from upstream. The deflector is attached to the inner and outer walls in a sealed manner, and the cooling air of the deflector is discharged from the chamber through exhaust holes formed in the inner and outer walls.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of hepatitis B virus infection. In particular, the present invention relates to farnesoid X receptor (FXR) agonists for use in a method for the treatment of hepatitis B virus infection in a subject in need thereof.

Abstract: An annular turbine engine combustion chamber wall including air admission orifices to create zones of steep temperature gradient, and cooling orifices to enable the air flowing on the cold side to penetrate to the hot side in order to form a film of cooling air along the annular wall, the annular wall being further includes, in the zones of steep temperature gradient, multi-perforation holes having respective bends of an angle ? greater than 90°, the angle ? being measured between an inlet axis Ae and an outlet axis As of the multi-perforation hole, the outlet axis of the multi-perforation hole being inclined at an angle ?3 relative to the normal N to the annular wall through which the multi-perforation holes with bends are formed, in a “gyration” direction that is at most perpendicular to the axial flow direction D of the combustion gas.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of hepatitis B virus infection. In particular, the present invention relates to farnesoid X receptor (FXR) agonists for use in a method for the treatment of hepatitis B virus infection in a subject in need thereof.

Abstract: The invention relates to a dyestuff of plant origin, obtained from a colored part of a plant species, the cell tissues of which contain iridisomes responsible for the coloration of said part. It relates most particularly to a blue dyestuff obtained from the arils of the seeds of the plant species Ravenala madagascariensis. It also relates to compositions, in particular cosmetic compositions, especially intended for making up the skin or superficial body growths, containing said dyestuff.

Abstract: The invention relates to the use of a Rhodiola crenulata extract, via the topical route, for increasing the energy metabolism of the cutaneous tissues of a subject. The invention relates notably to topical compositions which comprise an active agent for increasing the energy metabolism of the cutaneous tissues of a subject, said active agent being a Rhodiola crenulata extract. The present invention enables making a cosmetic care such as : fighting against, or slowing down or preventing the loosening of the cutaneous tissue, increasing the plasticity of the cutaneous tissue, exerting an anti-wrinkle effect or slowing down or preventing the appearance of wrinkles, fighting against, slowing down or preventing the appearance of acne, exerting a depigmenting effect of the cutaneous tissue, in particular of the skin, and promoting desquamation of the cutaneous tissue (or “peeling”).

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of polyomavirus infections. In particular, the present invention relates to a method for treating a polyomavirus infection in a subject in need thereof comprising administering the subject with a therapeutically effective amount of gemcitabine.