Patents by Inventor Patricia A. DeLeon

Patricia A. DeLeon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FERTILITY ENHANCEMENT USING LIPID CARRIERS AND BIOACTIVE MOLECULES
    Publication number: 20100317917
    Abstract: The invention relates to a method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor, (GPI-linked proteins), in the presence of a lipid carrier to the surface of epididymal or ejaculated sperm.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 16, 2010
    Inventors: Patricia A. DeLeon, Genevieve S. Griffiths
  • FERTILITY ENHANCEMENT USING LIPID CARRIERS AND BIOACTIVE MOLECULES
    Publication number: 20090263362
    Abstract: The invention relates to a composition and method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor (GPI-linked proteins) to the surface of epididymal or ejaculated sperm. The process may be facilitated or promoted in the presence of Clusterin/APOJ, a well-known lipid carrier. The rate of delivery, or removal, of bioactive molecules is regulated by the concentration of lipid carrier present. The acquisition of these molecules, such as Sperm Adhesion Molecule 1 (SPAM1) can significantly impact sperm maturation and function.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 22, 2009
    Applicant: University of Delaware
    Inventors: Patricia A. DeLeon, Genevieve S. Griffiths
  • In vitro uptake of SPAM 1 (PH-20) by mammalian sperm
    Patent number: 7531299
    Abstract: The invention relates to the in vitro transfer of the Sperm Adhesion Molecule 1 (SPAM 1) to spermatozoa. The SPAM1 protein can be obtained from the epididmys or the uterus and should have an intact lipid anchor. The SPAM 1 protein attaches to the surface of mammalian spermatozoa via it's lipid anchor in an in vitro environment in order to increase the sperm's capability of fertilizing an egg.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: May 12, 2009
    Assignee: University of Delaware
    Inventors: Patricia A. DeLeon, Hong Chen, Hong Zhang, Genevieve S. Griffiths
  • Fertility Enhancement Using Lipid Carriers and Bioactive Molecules
    Publication number: 20080160003
    Abstract: The invention relates to a composition and method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor (GPI-linked proteins) to the surface of epididymal or ejaculated sperm. The process may be facilitated or promoted in the presence of Clusterin/ApoJ, a well-known lipid carrier. The acquisition of these molecules, such as Sperm Adhesion Molecule 1 (SPAM1) can significantly impact sperm maturation and function.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 3, 2008
    Applicant: University of Delaware
    Inventors: Patricia A. DeLeon, Genevieve S. Griffiths
  • In vitro uptake of SPAM 1 (PH-20) by mammalian sperm
    Publication number: 20050210541
    Abstract: The invention relates to the in vitro transfer of the Sperm Adhesion Molecule 1 (SPAM 1) to spermatozoa. The SPAM1 protein can be obtained from the epididmys or the uterus and should have an intact lipid anchor. The SPAM 1 protein attaches to the surface of mammalian spermatozoa via it's lipid anchor in an in vitro environment in order to increase the sperm's capability of fertilizing an egg.
    Type: Application
    Filed: December 8, 2004
    Publication date: September 22, 2005
    Inventors: Patricia DeLeon, Hong Chen, Hong Zhang, Genevieve Griffiths