Abstract: The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided.

Abstract: The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.

Abstract: System and methods for minimally invasive treatment of snoring are described. According to one system and method, laser energy is applied to tissue of a soft palate and/or uvula to create a pattern of multiple treatment spots in the tissue. According to another system and method, electromagnetic energy from a filament light source is impinged of soft palate and/or uvula tissue to achieve volumetric heating of the tissue. The systems and methods increase rigidity and/or reduce laxity of the tissue, and/or volumetrically reduce the tissue, thereby diminishing snoring.