Abstract: The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2?, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

Abstract: Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: Providing a virtualized volume to a client and virtualized files on the virtualized volume by emulating a disk, emulating a file system, and storing an file corresponding to the each virtualized file on at least one of a plurality of volume layers.

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: A clothes line with a central frame member (8). Outwardly extending end members (4) and (6) supporting clothes line therebetween, and legs (10) and (12) at each end of the member (8) which are supported to be foldable, between a position where they lie alongside the member (8) to a position providing support for the member (8). And there are means between the legs (10) and (12) and the member (8) which provides a locking strut effect.

Abstract: A security camera system is provided. Several video cameras operate in conjunction with an image display monitor, a user control and camera selector means whereby a target of interest may be followed. Each two cameras providing adjacent areas of coverage are operable to provide an overlay image portion at transition regions of a displayed image. Upon movement of the target of interest to a specified transition region of a currently displayed image provided by one video camera, the camera selection means is operable to select a second camera whereby to maintain target display continuity by the monitor.

Abstract: The present invention relates to a method and system for providing biological detection. The system includes: at least one polymodal sensor for collectively detecting at least two conditions; and at least one node, each node including at least one of the polymodal sensors. The system also includes at least one data collector; each data collector communicating with one or more of the at least one node, and each data collector storing local information in a local knowledge base; and at least one server, each server communicating with one or more of the at least one data collector, and each server updating a global knowledge base. The at least two conditions are utilized in detecting the presence of biological activity from either one or both knowledge bases.

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: A method of tracking the position and orientation of an ultrasound beam emitted from an ultrasound probe. The method includes the steps of storing a model of the visible object in a memory of an optical tracking system; calculating the position and orientation of the visible object; and calculating the position and orientation of the ultrasound beam by applying a known geometric relationship to the deduced position and orientation of the visible object.

Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.

Abstract: A method for tracking the position and orientation of an ultrasound beam emitted from an ultrasound probe. The method comprises the steps of: storing a model of the visible object in a memory of an optical tracking system; calculating the position and orientation of the visible object; and calculating the position and orientation of the ultrasound beam by applying a known geometric relationship to the deduced position and orientation of the visible object.

Abstract: A security camera system is provided. Several video cameras operate in conjunction with an image display monitor, a user control and camera selector means whereby a target of interest may be followed. Each two cameras providing adjacent areas of coverage are operable to provide an overlay image portion at transition regions of a displayed image. Upon movement of the target of interest to a specified transition region of a currently displayed image provided by one video camera, the camera selection means is operable to select a second camera whereby to maintain target display continuity by the monitor.

Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R5)—═CH—, —S— or —O—.

Abstract: Described herein are compounds of formula (I) or a pharmaceutically acceptable salt thereof, ##STR1## wherein L is N or C, one of X and Y is --NH--CH.sub.2 --R.sup.2 and the other is the substituent of formula (II). The compounds are potent gastrin and/or CCK antagonists.