Patents by Inventor Patricia Coromoto BIASUTTO

Patricia Coromoto BIASUTTO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide therapy for Leber congenital amaurosis
    Patent number: 11920132
    Abstract: Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: March 5, 2024
    Assignee: ProQR Therapeutics II B.V.
    Inventors: Patricia Coromoto Biasutto, Hee Lam Chan
  • OLIGONUCLEOTIDE THERAPY FOR LEBER CONGENITAL AMAUROSIS
    Publication number: 20210139905
    Abstract: Antisense oligonucleotides target the mutation in introit 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Application
    Filed: January 8, 2021
    Publication date: May 13, 2021
    Inventors: Patricia Coromoto Biasutto, Hee Lam Chan
  • Oligonucleotide therapy for Leber Congenital Amaurosis
    Patent number: 10889817
    Abstract: Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: January 12, 2021
    Assignee: ProQR Therapeutics II B.V.
    Inventors: Patricia Coromoto Biasutto, Hee Lam Chan
  • OLIGONUCLEOTIDE THERAPY FOR LEBER CONGENITAL AMAUROSIS
    Publication number: 20200063134
    Abstract: Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Application
    Filed: September 20, 2019
    Publication date: February 27, 2020
    Inventors: Patricia Coromoto Biasutto, Hee Lam Chan
  • Oligonucleotide therapy for leber congenital amaurosis
    Patent number: 10421963
    Abstract: Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: September 24, 2019
    Assignee: ProQR Therapeutics II B.V.
    Inventors: Patricia Coromoto Biasutto, Hee Lam Chan
  • OLIGONUCLEOTIDE THERAPY FOR LEBER CONGENITAL AMAUROSIS
    Publication number: 20180030439
    Abstract: Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
    Type: Application
    Filed: February 26, 2016
    Publication date: February 1, 2018
    Inventors: Patricia Coromoto BIASUTTO, Hee Lam CHAN