Abstract: The present disclosure relates to compositions and methods for treating Sanfilippo syndrome (also known as Sanfilippo disease type D, Sanfilippo D, mucopolysaccharidosis type IIID, MPS IIID). The method can entail injecting to the spinal fluid of a MPS IIID patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (GNS) protein comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and having the enzymatic activity of the human GNS protein. The composition can be provided in an artificial cerebrospinal fluid. About 1 mg to about 100 mg of the recombinant polypeptide may be administered to the patient once every 2 weeks to 6 months.

Abstract: The present disclosure relates to compositions and methods for treating Sanfilippo syndrome (also known as Sanfilippo disease type D, Sanfilippo D, mucopolysaccharidosis type IIID, MPS IIID). The method can entail injecting to the spinal fluid of a MPS IIID patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (GNS) protein comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and having the enzymatic activity of the human GNS protein. The composition can be provided in an artificial cerebrospinal fluid. About 1 mg to about 100 mg of the recombinant polypeptide may be administered to the patient once every 2 weeks to 6 months.

Abstract: A treadmill has an endless belt and a housing supporting movement of the endless belt along the housing. The housing has a top surface, a bottom surface and a plurality vertical channels extending between the top surface and the bottom surface. Posts are vertically movable in the vertical channels. The posts are secured in a selected position in the vertical channels, with an upper portion of a selected length extending above the top surface and, if desired, a lower portion of a selected length extending below the bottom surface.

Abstract: A treadmill has an endless belt and a housing supporting movement of the endless belt along the housing. The housing has a top surface, a bottom surface and a plurality vertical channels extending between the top surface and the bottom surface. Posts are vertically movable in the vertical channels. The posts are secured in a selected position in the vertical channels, with an upper portion of a selected length extending above the top surface and, if desired, a lower portion of a selected length extending below the bottom surface.