Patents by Inventor Patricia L. Gladstone

Patricia L. Gladstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THIOTUNGSTATE ANALOGUES AND USES THEREOF
    Publication number: 20110151022
    Abstract: The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using novel thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders and obesity and methods of using pharmaceutical compositions of thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Application
    Filed: December 13, 2010
    Publication date: June 23, 2011
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L.P. Price, Andrew P. Mazar
  • Thiotungstate analogues and uses thereof
    Patent number: 7851505
    Abstract: The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using novel thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders and obesity and methods of using pharmaceutical compositions of thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 14, 2010
    Assignee: Attenuon, LLC
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L. P. Price, Andrew Mazar
  • Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
    Patent number: 7517855
    Abstract: The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, pharmaceutical compositions of these peptides and methods of using these peptides and pharmaceutical compositions of these peptides to treat diseases associated with aberrant vascularization.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 14, 2009
    Assignee: Attenuon, LLC
    Inventors: Robert J. Ternansky, Stephanie A. Hopkins, Won Hyung Yoon, Amy L. Allan, Patricia L. Gladstone, Sean M. O'Hare, Fernando Donate, Andrew Mazar, Graham Parry, Marian Plunkett
  • Acid Addition Salts of Ac-Phscn-Nh2
    Publication number: 20080261892
    Abstract: Acid addition salts of Ac—PHSCN—NH2, methods of making acid addition salts of Ac—PHSCN—NH2, pharmaceutical compositions of acid addition salts of Ac—PHSCN—NH2, methods of using acid addition salts of Ac—PHSCN—NH2 and pharmaceutical compositions thereof to treat diseases associated with angiogenesis and aberrant vascularization and methods of preventing degradation of Ac—PHSCN—NH2 by salt formation are provided herein.
    Type: Application
    Filed: February 1, 2006
    Publication date: October 23, 2008
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Andrew P. Mazar, Amy L. Allan
  • Thiomolybdate analogues and uses thereof
    Patent number: 7189865
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 13, 2007
    Assignees: Attenuon, LLC, Regents of the University of Michigan
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L. P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6969703
    Abstract: This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: November 29, 2005
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6790989
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: September 14, 2004
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli, Bin Chao, Steven D. Linton
  • Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
    Publication number: 20040162239
    Abstract: The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, pharmaceutical compositions of these peptides and methods of using these peptides and pharmaceutical compositions of these peptides to treat diseases associated with aberrant vascularization.
    Type: Application
    Filed: November 25, 2003
    Publication date: August 19, 2004
    Inventors: Amy L. Allan, Fernando Donate, Stephanie A. Hopkins, Patricia L. Gladstone, Andrew Mazar, Sean M. O'Hare, Graham Parry, Marian Plunkett, Robert J. Ternansky, Won Hyung Yoon
  • Thiomolybdate analogues and uses thereof
    Publication number: 20040019087
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation.
    Type: Application
    Filed: May 28, 2003
    Publication date: January 29, 2004
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L.P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Thiomolybdate analogues and uses thereof
    Publication number: 20040019043
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization.
    Type: Application
    Filed: July 23, 2002
    Publication date: January 29, 2004
    Inventors: Dimitri Coucouvanis, Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L.P. Price, Sean M. O'Hare
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20030199454
    Abstract: This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: 1
    Type: Application
    Filed: December 17, 2002
    Publication date: October 23, 2003
    Applicant: IDUN Pharmaceuticals, Inc.
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli
  • Methods, compositions and kits for preserving antigenicity
    Publication number: 20030039661
    Abstract: The present invention relates generally to programmed cell death and specifically to methods, compositions, and kits for preserving or enhancing antigenicity of markers associated with disease by utilizing inhibitors of apoptosis including interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors.
    Type: Application
    Filed: March 1, 2002
    Publication date: February 27, 2003
    Inventors: Teresa Aja, Brett W. Ching, Patricia L. Gladstone
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6525024
    Abstract: This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: February 25, 2003
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6515173
    Abstract: This invention s directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, p and q are as defined herein. The invention s all directed to pharmaceutical compositions containing one or more of thee compound, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that to undergo a transplantation procedure.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: February 4, 2003
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli
  • Inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20020137686
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: 1
    Type: Application
    Filed: July 18, 2001
    Publication date: September 26, 2002
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Kevin J. Tomaselli, Bin Chao, Steven D. Linton